Protein Alignment cindr and cd2ap

DIOPT Version :10

• Sequence 1: NP_001263129.1
• Gene: cindr / 43654
• FlyBaseID: FBgn0027598
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: NP_001008583.2
• Gene: cd2ap / 494040
• ZFINID: ZDB-GENE-030131-8078
• Length: 657
• Species: Danio rerio
• Alignment Length: 747
• Identity: 178/747 - (23%)
• Similarity: 264/747 - (35%)
• Gaps: 214/747 - (28%)

  Fly     8 IVEYEYAAKEPDELDLQKGAIIHRIKQM-PGGWWQGTLKASGVTGMFPDNFVRVL---------- 61
            :|||||.|...|||.|:.|.||..:::: ..||.:|.|  :|..|:||||||:.:
Zfish     5 VVEYEYEALHEDELTLRLGDIIKNVRRIEEEGWMEGDL--NGKRGLFPDNFVKEVRKDEPKSKEE 67

  Fly    62 ------------ESGVSSNGNGTTGS-----------GDHIEVGTAVQLR-DKSATSNRRCKVIY 102
                        ||.:....:|...|           ...|.:....|.| .|.....|:|||::
Zfish    68 SKEPKEAKEVKEESTIQRRASGNVASLVQRISTYGIPAGGIGLQPHSQPRASKKKLKKRQCKVLF 132

  Fly   103 SYTQVNDDELTLAVGDVIEFLGEVEEGWWRGRLRSKVGVFPSNFVQHI------EPSPV------ 155
            .|...|:|||.|.||::||...|||||||.|.:..|.|:||||||:.|      |.|.|
Zfish   133 EYVPQNEDELELKVGEIIEITEEVEEGWWSGSMNGKSGLFPSNFVKEIDSTEDAENSDVTEEQDT 197

  Fly   156 ---LASKRPPTIGATVTTSALTSKAANVANVAATATVPTGGAVPPASTSISTSTTKQATKSRATA 217
               .:|...|..|..|.......|.....::....:|....::...|.::..:.........||.
Zfish   198 RDGTSSPTSPHPGNGVMAQPKKIKGIGFGDIFREGSVKLRTSLKGPSENMEKTEKPIPPLPSATK 262

  Fly   218 AAAASAPAEPAAIVSGSGAAAGGGAAAAVPMLPPKPQREFCRVEFPYAPQNDDELELKVDDIIAV 282
            ....|.|..|.........|               ..:|:|:..|.|...|.|||:||..::|.:
Zfish   263 PTPLSTPEHPKGEKEAESKA---------------KVKEYCKATFHYEATNQDELDLKEGEVILI 312

  Fly   283 ISTELPDKGWWKGEIRGKVGVFPDNFVKML------------------------------APSEA 317
            :|.:..:.|||:||:.||.||||||||.:|                              .||::
Zfish   313 LSKDTGEPGWWRGEVNGKQGVFPDNFVSLLPESDKETLTSKGSIKVLSKQEPEERPKKPPPPSKS 377

  Fly   318 TAAPP--------LPRPRPRTRPGMGGTGAGSGSGIIDGVRTPRRTQRGGSFEFLGARMASFITT 374
            |...|        .|:|||..:
Zfish   378 TVLKPETPSVDKKQPQPRPEDK------------------------------------------- 399

  Fly   375 IFAPINEPPS--ATQITQNQRKVSNTASTTSHMTTTNSSNSSTTSVTTQQQKEQ----IGGSSST 433
            :..|:.|.|:  |..|...::.|..:.|.......|...:...|.....:|.:.    :....|.
Zfish   400 VVKPLPEKPAKPAGPIVPPKKPVPPSKSLLRPSYHTKRPDLPLTPSPAAKQVQNGDVPLSRRKSE 464

  Fly   434 TSKVYIK-KT----GSSSNSTTSSTTTASSSAGRKESFGSRDSLNDILSETGLPTGNVAAQRKSL 493
            ...|.|| ||    |..|..|.:..           ||....|.::.||.   ||    |||..:
Zfish   465 CEPVPIKPKTVVDIGEKSTETVNLM-----------SFDDVSSSSEKLSH---PT----AQRPKM 511

  Fly   494 ENKNLDLTKPP---GVGASVSIGQQRSSTSSATTSSATTVATGLTSSSVSKSMENMLDEKVKSPP 555
            ..|     :||   |...|..:|::...|..  .....|..:...:.:.:.|.:|.:...:.||.
Zfish   512 PGK-----RPPAHRGHSPSKDVGEKAEKTEK--IDEVETAPSPAPAPAPAPSTQNSIKMPISSPL 569

  Fly   556 PPVLSKKPSVPLKKTPTGGVPMTGNLLGGKKKNTEGKLTTAVSHDLAD---GLAASKMLSGANQL 617
            |....|..|..| .||.           .|.|..:.:..|:...:|.|   .|..|..|....|.
Zfish   570 PSTTPKTISATL-ITPE-----------PKPKPDKEQEKTSELEELKDQIKDLVLSVELLKTQQS 622

  Fly   618 PESGAAGNVVIRRAATIAVEDTDFDRVERASI 649
            .|.|.     :|:       :.|.:|::|.::
Zfish   623 RELGE-----LRK-------ELDDERLKRVAL 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cindr	NP_001263129.1	SH3_CD2AP-like_1	6..60	CDD:212806	25/52 (48%)
		SH3_CD2AP-like_2	97..149	CDD:212807	29/51 (57%)
		SH3_CD2AP-like_3	258..310	CDD:212808	25/51 (49%)
cd2ap	NP_001008583.2	SH3_CD2AP_1	12..58	CDD:212986	20/47 (43%)
		SH3_CD2AP_2	126..180	CDD:212987	30/53 (57%)
		SH3_CD2AP_3	285..341	CDD:212989	27/55 (49%)
		COG2433	<599..>652	CDD:441980	12/56 (21%)