Protein Alignment cindr and Sh3d21

DIOPT Version :10

• Sequence 1: NP_001263129.1
• Gene: cindr / 43654
• FlyBaseID: FBgn0027598
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: XP_008762271.1
• Gene: Sh3d21 / 362598
• RGDID: 1305090
• Length: 729
• Species: Rattus norvegicus
• Alignment Length: 903
• Identity: 201/903 - (22%)
• Similarity: 300/903 - (33%)
• Gaps: 297/903 - (32%)

  Fly     8 IVEYEYAAKEPDELDLQKGAIIHRIKQMPG-GWWQGTLKASGVTGMFPDNFVRVLESGVSSNGNG 71
            :|...|.|:..|||.|..|.:|.::..:|. ||..|.|:  |..|:||...|:.:...:    .|
  Rat    74 LVLARYRAQTEDELSLAPGDVIQQVCAVPARGWLLGELR--GRRGLFPKRLVQEIPEAL----RG 132

  Fly    72 TTGS--------GDHIEVGTAVQLRDKSATSNRRCKVIYSYTQVNDDELTLAVGDVIEFLGEVEE 128
            .|.|        |..|:          |.:..|.|||.::|:....|||.|.:|:::|.:.|:|:
  Rat   133 VTESRPRFPRRRGHPID----------SQSPQRWCKVNFNYSPEQADELKLQIGEILEVIKEIED 187

  Fly   129 GWWRGRLRSKVGVFPSNFVQHIEPSPVLASKRPPTIGATVTTSALTSKAANVANVAATATVPTGG 193
            |||.|:...::|.||||||:       |....||::|                |....:.:||..
  Rat   188 GWWLGKKNGQLGAFPSNFVE-------LLDSGPPSLG----------------NTDMPSIIPTSQ 229

  Fly   194 AVPPASTSISTSTTKQATKSRATAAAAASAPAEPAAIVSGSGAAAGGGAAAAVPMLPPKPQREFC 258
            . ||..::::..:.....::       .|.|                               |.|
  Rat   230 R-PPKLSNLTYDSPPDYLRT-------VSCP-------------------------------ETC 255

  Fly   259 RVEFPYAPQNDDELELKVDDIIAVISTELPDKGWWKGEIRGKVGVFPDNFVKMLAPSEATAAPPL 323
            ||.|.|.|:..|||.|:..|::.|:.....|||||:||.:|:.||||||||  :.|      ||:
  Rat   256 RVLFDYQPEAPDELALQKGDLVKVLRKTTEDKGWWEGECQGRRGVFPDNFV--IPP------PPI 312

  Fly   324 PRPRPRTRPGMGGTGAGSGSGIIDGVRTPRRTQRGGSFEFLGARMASFITTIFAPINE-----PP 383
            .:..||                                        ..|:...|||.|     |.
  Rat   313 RKLIPR----------------------------------------KIISRESAPIKETKKLMPK 337

  Fly   384 SATQITQNQRKVSNTASTTSHMTTTNSSNSSTTSVTTQQQKEQIGGSSSTTSKVYIKKTGSSSNS 448
            |:....   :|::..|...|     .:...||.:|.:|::..:..|.:           |...|:
  Rat   338 SSLPTV---KKLAAAAPAPS-----KAKPPSTLNVDSQKRPSRNSGFN-----------GGCLNA 383

  Fly   449 TTSSTTTASSSAGRKESFGSRDSLNDILSETGLPTGNVAAQRKSLENKNLDLTKPPGVGASVSIG 513
                   .|...|||   |||...:...|:.                   |..|.||.|.|
  Rat   384 -------GSRQPGRK---GSRTLQHSASSQE-------------------DEQKSPGKGPS---- 415

  Fly   514 QQRSSTSSATTSSATTVATGLTSSSVSKSMENMLDEKVKSPPPPVLSKKPSVPLKKTPTGGVPMT 578
              ||.|               .:|..|:..|..||.:....|..|.:.|..||.|...:..:|.|
  Rat   416 --RSKT---------------PTSEKSRLPEKALDPEPIPAPDKVSTPKDLVPEKAPDSDKIPTT 463

  Fly   579 GN------------LLGGKKKNTEG-KLTTAVSHDLADGLAASKMLSGANQLPESGAAGNVVIRR 630
            .|            |.|.:....|. .|.||...|.|..|.  |:|:     ||.
  Rat   464 ENTTLVKAVTPESALSGDEPAKDEALDLKTAPHVDSAPALV--KILT-----PEH---------- 511

  Fly   631 AATIAVEDTDFDRVERASILTDMRQGRVKAPKRRPPSAAINVLGES--NNNSVYVNG--SGMSGS 691
              .|..|:...|.::                .:..|........||  :.|.:.|.|  |....|
  Rat   512 --MIFKEEPSKDNIQ----------------YQHSPQEETTQRSESFISPNDIQVQGEYSPQPNS 558

  Fly   692 GGAGSASELSEDGGAGGKTSDDNSTGEEPQ-LAKPKPREWEKKKAPWMEELKASQVTRKKTSPSV 755
            ............|......::|.|..||.. |.||               |...::|.....|..
  Rat   559 SDPSCCGVKQVSGSPAQSKAEDVSAMEEANFLRKP---------------LAKDEITPNSALPKK 608

  Fly   756 EPRGASVAERTSKLFAAEQAVSSNSSSITTKVQSSAVTSSMFVENSTTSSSV-ITSSSHTTTNDA 819
            .|...          |..|.......|:.|......|......|..|...|| :||..  :.||:
  Rat   609 LPSEG----------AGPQKQVLPQESVPTPQVPHTVKKIPDPEAPTLQPSVPLTSPK--SKNDS 661

  Fly   820 IMSRSLSAAKVQTASSDEETRATRPNSLAIRNQRSVSPLVKSSNASSSQSQEEKPTSQ 877
            :....|..|:|.:..:       |...|.::.::.:..:.|.......||.|.:.|.:
  Rat   662 VDELELLKAEVNSLKN-------RLALLELKLEQKMGEVWKELKTEKLQSPEVQMTQR 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cindr	NP_001263129.1	SH3_CD2AP-like_1	6..60	CDD:212806	19/52 (37%)
		SH3_CD2AP-like_2	97..149	CDD:212807	23/51 (45%)
		SH3_CD2AP-like_3	258..310	CDD:212808	27/51 (53%)
Sh3d21	XP_008762271.1	SH3	72..125	CDD:473055	19/52 (37%)
		SH3_CD2AP-like_2	156..208	CDD:212807	23/58 (40%)
		SH3_D21-like	255..308	CDD:213018	28/54 (52%)
		PTZ00449	<388..664	CDD:185628	79/380 (21%)