DRSC/TRiP Functional Genomics Resources

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Protein Alignment cindr and SH3KBP1

DIOPT Version :9

Sequence 1:NP_001263129.1 Gene:cindr / 43654 FlyBaseID:FBgn0027598 Length:941 Species:Drosophila melanogaster
Sequence 2:XP_011543800.1 Gene:SH3KBP1 / 30011 HGNCID:13867 Length:709 Species:Homo sapiens


Alignment Length:1015 Identity:228/1015 - (22%)
Similarity:325/1015 - (32%) Gaps:410/1015 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 AIVEYEYAAKEPDELDLQKGAIIHRIKQMPGGWWQGTLKASGVTGMFPDNFVRVLESGVSS---- 67
            ||||::|.|:..|||.:..|.||..|::..||||:|.:  :|..|:|||||||.::..:..    
Human     4 AIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQI--NGRRGLFPDNFVREIKKEMKKDPLT 66

  Fly    68 ------------NGNGTTGSGDHIEVGTAVQLRDKSATSNRRCKVIYSYTQVNDDELTLAVGDVI 120
                        :||....|      .|.::...:.....|||:|.:||...|||||.|.|||:|
Human    67 NKAPEKPLHEVPSGNSLLSS------ETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDII 125

  Fly   121 EFLGEVEEGWWRGRLRSKVGVFPSNFVQHIE----------------------------PSPVLA 157
            |.:||||||||.|.|..|.|:|||||::.:.                            |.|...
Human   126 EVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSRPEGLPPASLLPFPAHG 190

  Fly   158 SKRPPTIGATVTTSALTSKAANVANVAATATVPTGG-----AVPPASTSISTSTTKQATKSRATA 217
            :|...|...|:...|...|              |.|     ::...:.|.|......:|||....
Human   191 AKGKTTFEGTILYRAAPGK--------------TEGHRRYYSLRETTGSESDGGDSSSTKSEGAN 241

  Fly   218 AAAASAPAEPAAIVSGSGAAAGG-------------------------------GAAAAVP---- 247
            ...|:|..:|..:   .|...|.                               .|..|.|    
Human   242 GTVATAAIQPKKV---KGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSK 303

  Fly   248 --MLPPKPQREFCRVEFPYAPQNDDELELKVDDIIAVISTELPDKGWWKGEIRGKVGVFPDNFVK 310
              |......:::|:|.|||..||||||.:|..||:.:|:.:..|.|||:||:.|:.|||||||||
Human   304 TEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVK 368

  Fly   311 MLAP---SEATAAPPLPRPRPRTRPGMGGTGAGSGSGIIDGVRTPRRTQRGGSFEFLGARMASFI 372
            :|.|   .|..        ||:..|                                        
Human   369 LLPPDFEKEGN--------RPKKPP---------------------------------------- 385

  Fly   373 TTIFAPINEPPSATQITQNQRKVSNTASTTSHMTTTNSSNSSTTSVTTQQQKEQIGGSSSTTSKV 437
                     ||||..|.|                                      |:.:|..|.
Human   386 ---------PPSAPVIKQ--------------------------------------GAGTTERKH 403

  Fly   438 YIKKTGSSSNSTTSSTTTASSSAGRKESFGSRDSLNDILSETGLPTGNVAAQRKSLENKNLDLTK 502
            .|||....                |.|.               ||......:|...|.| |||.|
Human   404 EIKKIPPE----------------RPEM---------------LPNRTEEKERPEREPK-LDLQK 436

  Fly   503 PPGVGASVSIGQQRSSTSSATTSSATTVATGLTSSSVSKSMENMLDEKVKSPPPPVLSKKPSVPL 567
            |                                              .|.:.||    |||..| 
Human   437 P----------------------------------------------SVPAIPP----KKPRPP- 450

  Fly   568 KKTPTGGVPMTGNLLGGKKKNTEGKLTTAVSHDLADG----LAASKMLSGANQLPESGAAGNVVI 628
               .|..:...|.|...:.:...|.||    |...|.    ||.|.:         ||.....:.
Human   451 ---KTNSLSRPGALPPRRPERPVGPLT----HTRGDSPKIDLAGSSL---------SGILDKDLS 499

  Fly   629 RRAATIAVEDTDFDRVERASILTDMRQGRVKAPKRRPPSAAINVLGESNNNSVYVNGSGMSGSGG 693
            .|:..|.:|..| ..|.....|:.....|.||..|||||.::                       
Human   500 DRSNDIDLEGFD-SVVSSTEKLSHPTTSRPKATGRRPPSQSL----------------------- 540

  Fly   694 AGSASELSEDGGAGGKTSDDNSTGEEPQL-AKPKPREWEKKKAPWMEELKASQVTRKKTSPSVEP 757
              ::|.||                 .|.: ..|.|.|                  .|:...|:..
Human   541 --TSSSLS-----------------SPDIFDSPSPEE------------------DKEEHISLAH 568

  Fly   758 RGASVAERTSKLFAAEQAVSSNSSSITTKVQSSAVTSSMFVENSTTSSSVITSSSHTTTNDAIMS 822
            ||...:::|||.....| ||.|.:|:..|..:.|.........|:.:.|.::||..|..:     
Human   569 RGVDASKKTSKTVTISQ-VSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGH----- 627

  Fly   823 RSLSAAKVQTASSDEETRATRPNSLAIRNQRSVSPLVKSSNASSSQSQEEKPTSQ-------LNN 880
                             ||..|:......:..:.|      |:|||:..|:..:|       :..
Human   628 -----------------RANSPSLFGTEGKPKMEP------AASSQAAVEELRTQVRELRSIIET 669

  Fly   881 HQDASSSRVAQLEQRVDKLEGLVLNQQRTIEELVNALKSE 920
            .:|.....:.||...:|:.:.:.|..|..:.::..||:|:
Human   670 MKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK 709

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cindrNP_001263129.1 SH3_CD2AP-like_1 6..60 CDD:212806 26/52 (50%)
SH3_CD2AP-like_2 97..149 CDD:212807 33/51 (65%)
SH3_CD2AP-like_3 258..310 CDD:212808 29/51 (57%)
SH3KBP1XP_011543800.1 SH3_CIN85_1 3..55 CDD:212985 26/52 (50%)
SH3_CIN85_2 102..154 CDD:212988 33/51 (65%)
SH3_CIN85_3 315..370 CDD:212990 31/54 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141489
Domainoid 1 1.000 71 1.000 Domainoid score I9451
eggNOG 1 0.900 - - E1_KOG4348
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1577081at2759
OrthoFinder 1 1.000 - - FOG0002275
OrthoInspector 1 1.000 - - otm41585
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR14167
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5319
SonicParanoid 1 1.000 - - X1165
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.840

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