DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cindr and Sh3d19

DIOPT Version :9

Sequence 1:	NP_001263129.1	Gene:	cindr / 43654	FlyBaseID:	FBgn0027598	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	XP_006501609.3	Gene:	Sh3d19 / 27059	MGIID:	1350923	Length:	1211	Species:	Mus musculus

Alignment Length:	340	Identity:	86/340 - (25%)
Similarity:	138/340 - (40%)	Gaps:	80/340 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AIVEYEYAAKEPDELDLQKGAIIHRIKQMPGGWWQGTLKASGVTGMFPDNFVRVLESGVSSNGNG 71
            |:..:::.|::.|:|.|..|.|::.::::...|::|  |....||:||.|:|:|:..........
Mouse   921 AVALHDFPAEQADDLSLTSGEIVYLLEKIDAEWYRG--KCRNQTGVFPANYVKVIVDIPEGRSGK 983

  Fly    72 TTGSGDHIEVGTAVQLRDKSATSNRRCKVIYSYTQVNDDELTLAVGDVIEFLGEVEEGWWRGRLR 136
            ......|...|.             ||...:.|.....|||:.:.|:||.....|.|.|.||.:|
Mouse   984 RESFSSHCAKGP-------------RCVARFEYIGDQKDELSFSEGEVIILTEYVNEEWGRGEIR 1035

  Fly   137 SKVGVFPSNFVQHIEPSPVLASKRPPTIGATVTTSALTSKAANVANVAATATVPTGGAVPPASTS 201
            .:.|:||.|||:.:...        ||.||.:.::.:..|..|               ..|.|.|
Mouse  1036 DRSGIFPLNFVELVGDH--------PTSGANILSTKVPPKTKN---------------EDPGSNS 1077

  Fly   202 ISTSTTKQATKS--RATAAAAASAPAE---------------------------PAAIVSGSGAA 237
            ..:|...:..|:  ..||..:...|.:                           ||..|....|.
Mouse  1078 QDSSPPGEWCKALHSFTAETSEDLPFKRGDRILILERLDSDWYRGRLHDREGIFPAVFVQPCPAE 1142

  Fly   238 AGGGAAAAVPMLPPKPQREFCRVEFPYAPQNDDELELKVDDIIAVISTELP--DKGWWKGEIRGK 300
            |.|.|:|.     ||.::  .:..:.:..:|:|||..|..|:|    |||.  |..|.:||:.|:
Mouse  1143 AKGVASAI-----PKGRK--VKALYDFLGENEDELSFKAGDVI----TELEPIDDAWMRGELMGR 1196

  Fly   301 VGVFPDNFVKMLAPS 315
            .|:||.|:|:.|..|
Mouse  1197 AGMFPKNYVQFLQVS 1211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cindr	NP_001263129.1	SH3_CD2AP-like_1	6..60	CDD:212806	16/52 (31%)
		SH3_CD2AP-like_2	97..149	CDD:212807	21/51 (41%)
		SH3_CD2AP-like_3	258..310	CDD:212808	19/53 (36%)
Sh3d19	XP_006501609.3	PHA03247	<50..375	CDD:223021
		PTZ00449	<245..705	CDD:185628
		SH3_Eve1_1	840..889	CDD:212748
		SH3	920..971	CDD:388381	15/51 (29%)
		SH3_Eve1_3	996..1046	CDD:212750	19/49 (39%)
		SH3	1086..1135	CDD:388381	6/48 (13%)
		SH3	1155..1204	CDD:388381	18/54 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910