Protein Alignment cindr and Sh3pxd2b

DIOPT Version :10

• Sequence 1: NP_001263129.1
• Gene: cindr / 43654
• FlyBaseID: FBgn0027598
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: XP_006514775.1
• Gene: Sh3pxd2b / 268396
• MGIID: 2442062
• Length: 936
• Species: Mus musculus
• Alignment Length: 893
• Identity: 179/893 - (20%)
• Similarity: 277/893 - (31%)
• Gaps: 302/893 - (33%)

  Fly     8 IVEYEYAAKEPDELDLQKGAIIHRIKQMPGGWW-------QGTLKASGVTGM--FPDNFVRVLES 63
            :|..:|..:|..|:.|..|.::..|::...|||       ||.:.|:.:.|.  ..|.|....|.
Mouse   158 VVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEE 222

  Fly    64 GVSSNGNGTTGSGDHIEVGTAVQLRDKSATSNR---RCKVIYSYTQVNDDELTLAVGDVIEFLGE 125
             ||........|     ||....|.|..|.|.|   :..|||.||..:.||:.|..|.|:|.:.:
Mouse   223 -VSWRYCSLPRS-----VGRRRTLGDLYAISWRQEEKYTVIYPYTARDQDEMNLERGAVVEVVQK 281

  Fly   126 VEEGWWRGRLRSKVGVFPSNFVQHIEPSPVLASKRPPTIGATVTTSALTSKAANVANVAATATVP 190
            ..||||:.|.:.|.|..|:::::.....|:     ||.:|   .:|...|.|.::..|:......
Mouse   282 NLEGWWKIRYQGKEGWAPASYLKKNSGEPL-----PPKLG---PSSPAHSGALDLDGVSRHQNAM 338

  Fly   191 ---------------TGGAVPPASTSISTSTTKQATKSRATAAAAASAPAEPAAIVSGSGAAAGG 240
                           .|..||...           .|.|:........|.....|..|.....
Mouse   339 GREKELLNNQRDGRFEGRLVPDGD-----------VKQRSPKMRQRPPPRRDMTIPRGLNLPK-- 390

  Fly   241 GAAAAVPMLPPKPQREFCRVEFPYAPQNDDELELKVDDII---AVISTELPDK---GWWKGEIRG 299
                  |.:||:.:.|:..:.         |.:..:.|.|   |.:..|:.:|   |||..::..
Mouse   391 ------PPIPPQVEEEYYTIA---------EFQTTIPDGISFQAGLKVEVIEKSLSGWWYIQMED 440

  Fly   300 KVGVFPDNFVKMLAPSEATAAP----PLPRPRPRTRPG--------MGGTGAG-------SGSGI 345
            |.|..|..|:.....:.:.:.|    |||....:.|.|        .|....|       :..|.
Mouse   441 KEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLGDAAATENNTGPEAVGPSRPLPEAPHGA 505

  Fly   346 IDGVRTPRRTQRGGSFEFLGARMASFITTIFAPINEPPSATQITQNQRKVSNTASTTSHMTTTNS 410
            :|......:..:||                    .|.|         ||.|:..|.        |
Mouse   506 VDSGMLWSKDWKGG--------------------KEAP---------RKASSDLSA--------S 533

  Fly   411 SNSSTTSVTTQQQKEQIGGSSSTTSKVYIKKTGSSSNSTTSSTTTASSSAGRKESFGSRDSLNDI 475
            :.....|..||::|                                .|...||||.        |
Mouse   534 TGYEEISDPTQEEK--------------------------------PSLPPRKESI--------I 558

  Fly   476 LSETGLPTGNVAAQRKSLENKNLDLTKPPGV--------GASVSIGQQRSSTSSATTSSATTVAT 532
            .||..|    :..:|:.:|.......||||:        .|.::...::.......:........
Mouse   559 KSEEEL----LERERQKMEPLRGSSPKPPGMILPMIPAKHAPLARDSRKPEPKLDKSKFPLRNDM 619

  Fly   533 GLTSS--------------SVSKSMENMLDEKVKSPPPPVLSK-KPSVPLKKTPTGGVPMT---- 578
            ||...              .:|:|...:.:|||......:..| :|.|..|.||:   |.|
Mouse   620 GLECGHKVLAKEVKKPNLRPISRSKAELSEEKVDPTSQNLFMKSRPQVRPKPTPS---PKTEPAQ 681

  Fly   579 ---------------------GNLLGGKKKNTEGKLTTAVSHDL--ADGLAASKMLSGANQLPES 620
                                 ..||.|:..:..|...||:|...  .:|....:..||.    :.
Mouse   682 SEDHVDIYNLRSKLRPAKSQEKALLDGESHHAAGSHDTALSRSFLPGEGPGHGQDRSGR----QD 742

  Fly   621 GAAGNVVIRRAATIAVEDTDFD------RVERASILTDMRQGRVKAPKRRPP------SAAIN-- 671
            |.:......||.....:.||..      .|:.|::     |.|...|.||||      |:.::
Mouse   743 GLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEATL-----QQRPVVPPRRPPPPKKTSSSPLSCR 802

  Fly   672 ----VLGESNNNSVYVNGSG----------------------MSGSGGAG-------------SA 697
                |.|.....|.....:|                      |.|.||.|             :|
Mouse   803 PLPEVRGAQREESRVAPAAGRALLVPPKAKPFLSNSSVGQDDMRGKGGLGPRVTGKVGETREKAA 867

  Fly   698 SELSEDGG--------AGGKTSDDNSTGEEPQLAKPKPREWEKKKAPW 737
            |.|:.||.        |..:..:|.|:.:|..:.:.:    ||..:.|
Mouse   868 SFLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVR----EKNSSGW 911

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cindr	NP_001263129.1	SH3_CD2AP-like_1	6..60	CDD:212806	16/60 (27%)
		SH3_CD2AP-like_2	97..149	CDD:212807	19/51 (37%)
		SH3_CD2AP-like_3	258..310	CDD:212808	13/57 (23%)
Sh3pxd2b	XP_006514775.1	PX_FISH	7..125	CDD:132798
		SH3_Tks4_1	155..209	CDD:213008	13/50 (26%)
		SH3_Tks4_2	252..305	CDD:213009	19/52 (37%)
		SH3_Tks4_3	400..452	CDD:213011	14/60 (23%)
		SH3_Tks4_4	879..934	CDD:212951	7/37 (19%)