DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cindr and SPBC800.10c

DIOPT Version :9

Sequence 1:	NP_001263129.1	Gene:	cindr / 43654	FlyBaseID:	FBgn0027598	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_595112.1	Gene:	SPBC800.10c / 2540824	PomBaseID:	SPBC800.10c	Length:	1116	Species:	Schizosaccharomyces pombe

Alignment Length:	974	Identity:	191/974 - (19%)
Similarity:	321/974 - (32%)	Gaps:	305/974 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VTGMFPDNFVRVLESGVSSNGNGTTGSGDHIEVGTAVQLRDKSATSNRRCKVIYSYTQVNDDELT 113
            ::|:....||::......|:|:|:.||                           ....::.||:|
pombe    99 ISGVDSSKFVQLNRPNNVSSGDGSDGS---------------------------FLPPISSDEMT 136

  Fly   114 --------------LAVGD-----------VIEFLGEVEEGWWR---GRLRSKVGVFPSNFVQHI 150
                          |..||           ..|.|..|    |.   ...|..:.:...|...||
pombe   137 RYQQMFTTVCPTDGLMDGDRASSIFGRAPLSTEILARV----WNLVDTHKRGALDIREFNTGMHI 197

  Fly   151 EPSPVLASKRPPTIGATVTTSALTSKAANVANVAATATVPTGGAVPPASTSISTSTTKQATKSRA 215
            ....:..|.:.|.:  :::.|.:.| ||:.::|:|.:..|.....||..
pombe   198 INLLLNGSLKSPPV--SISPSFIAS-AASTSSVSAPSQYPGLSRSPPVQ---------------- 243

  Fly   216 TAAAAASAP-AEPAAIVSGSGAAAGGGAAAAVPMLPPKPQREFCRV------------------E 261
                |.:.| ::|.||                   |.:....||::                  .
pombe   244 ----APNIPVSDPWAI-------------------PSQDLTSFCQLFSNVDKAHKGYVSGSEAYS 285

  Fly   262 FPYAPQNDDELELKVDDIIAVISTELPDKGWW-------KGEIRGK--VGVFPDNFVKMLAP--- 314
            |..|.:..:::..::.|:....|....:.|.:       |.::.||  ..|.|.:.:..:||
pombe   286 FFLASKLPEDVLAQIWDLSDTNSNGKLNIGEFCISLYLIKLKLSGKELPKVLPSSMLSSVAPLMQ 350

  Fly   315 ---SEATAAPPL-------PRPRPRTRPGMGGTGAGSGSGIIDGVRTPRRTQRGGSFEFLGARMA 369
               |..|:.|.:       |.|.|...|...|               |.|...|..      .:.
pombe   351 KSKSVPTSIPSVVPANISSPNPNPTLAPNPTG---------------PSRVTSGTE------DLL 394

  Fly   370 SFITTIFAPINEPPSATQITQNQRKVSNTASTTSHMTTTNSSNSSTTSVTTQQQKEQIGGSSSTT 434
            |...|.|:|...|         |...||   .|.|.....:.::....|:..|.....|..:|..
pombe   395 SLDATPFSPTLAP---------QHTSSN---ATKHSAPPVTKSAPFPVVSPLQLNHTPGFPTSPA 447

  Fly   435 SKVYIKKTGSSSNSTTSSTTTASSSAGRKESFGSRDSLNDILSETGLPTGNVAA---QRKSLENK 496
            :|         .||.| ||....||.|:..:..:.|..:.:  .|.:|: .:||   |..|.|..
pombe   448 AK---------PNSPT-STFFPQSSFGQTIAKNTMDKPSAV--RTSVPS-QLAAPIPQVASAEQL 499

  Fly   497 NLDLTKPPGVGASVSIGQQRSSTSSATTSSATTVATGLTSSSVSKS-MENMLDEKVKSPPPPVLS 560
            .| ..:.|.:.:.:|   |...::.....|:..||..|:......| :....||:        |:
pombe   500 KL-AAEVPKLESQLS---QVKKSNDDLQKSSRDVAANLSDVKAKVSEIRKAYDEE--------LA 552

  Fly   561 KKPSVPL----KKTPTGGVPMTGNLLGG------KKKNTEGKLTTAVSHDLADGLAASKMLSGAN 615
            |...:.|    .|..|..|....::|..      |:...:|::...|   :|:..||..|:..:|
pombe   553 KAKQISLDIETNKAQTEQVNREYSILEATLNALQKQNKQKGEVLEQV---VAESEAAKNMVESSN 614

  Fly   616 ----QLPESGAAGNVVIRRAATIAVEDTDFDRVERASILTDMRQGRVKAPKRRPPSAAINVLGES 676
                ||...      |..:..|:|......|.:.:..:..|...   ||..:|.......:
pombe   615 ASIQQLKSE------VADKEQTLAQLHLQLDEMTQRLVSLDEES---KAVSQRKLDLEYKI---- 666

  Fly   677 NNNSVYVNGSGMSGSGGAGSASELSEDGGAGGKTSDDNSTGEEPQLAKPKPREWEKKKAPWMEE- 740
             |||                            ||  ..:|..|......|..|.||::...:|:
pombe   667 -NNS----------------------------KT--QLATATEEYHEHSKQLEAEKQELSKLEDG 700

  Fly   741 LKASQVTRKKTSPSVE--PRGASVAERTSKLFAAEQAVSSNSSSITTKVQSSAVTSSMFVENSTT 803
            ||:..:|.:...|.|:  ||..|..  ::.:...:..:...:||:.|:..|.....:.....|..
pombe   701 LKSVNLTEEAPKPEVDSTPRFPSFT--SNGITTDKPTLPDTTSSVPTQHNSFDAMHNTLRSPSLN 763

  Fly   804 SSSVITSSSHTTTNDAIMSRS-LSAAKVQTASS-------DEETRATRPNSLAIRNQRSVSPLVK 860
            |::   ||:|.:|    :||: ....|:..|||       .|...|..|.|::.....||
pombe   764 SNN---SSAHAST----VSRNPFHNLKISGASSPVSNFWESEFASAVFPRSISKTTSLSV----- 816

  Fly   861 SSNASSSQSQEEKPTSQLNN-----HQDAS--------SSRVAQLEQRVDKLEGLVLNQQRTIE 911
             :|:|.:.|.:.:|. ||:|     |||:|        |.|.:.:...:.||.|...|....:|
pombe   817 -NNSSVNPSLDSEPV-QLSNMEEPQHQDSSVVDVSTSASQRGSPVLSDLSKLTGSARNTAEPVE 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cindr	NP_001263129.1	SH3_CD2AP-like_1	6..60	CDD:212806	3/10 (30%)
		SH3_CD2AP-like_2	97..149	CDD:212807	12/79 (15%)
		SH3_CD2AP-like_3	258..310	CDD:212808	11/78 (14%)
SPBC800.10c	NP_595112.1	EH	13..79	CDD:238009
		EH	138..203	CDD:238009	11/68 (16%)
		EH	252..345	CDD:197477	16/111 (14%)
		EH	263..329	CDD:238009	8/65 (12%)
		KASH_CCD	493..701	CDD:291334	50/266 (19%)
		BAR	499..704	CDD:299863	50/263 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9305
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000