DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cindr and ucp8

DIOPT Version :9

Sequence 1:	NP_001263129.1	Gene:	cindr / 43654	FlyBaseID:	FBgn0027598	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_595633.2	Gene:	ucp8 / 2540786	PomBaseID:	SPBC83.01	Length:	829	Species:	Schizosaccharomyces pombe

Alignment Length:	716	Identity:	135/716 - (18%)
Similarity:	234/716 - (32%)	Gaps:	225/716 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ENNICAIVEYEYAAKEPDELDLQKGAIIHRIKQMPGGWWQGTLKASGVTGMFPDNFVRVLESGVS 66
            :||..:.|:.:|:: .|..:|             |    |..:||. :|.....||.: |.|.:.
pombe   268 DNNAQSAVDNKYSS-PPQTID-------------P----QANIKAL-ITPEDRSNFYQ-LFSKID 312

  Fly    67 SNGNGTTGSGD--------HIEVGTAVQLRDKSATSNRRCKVIYSYTQVNDDELTLAVGDVIEFL 123
            :...|....|:        |::.....::.|...|.:|      .|  ::.||..:|:
pombe   313 NENKGYIVGGEAVPFFMASHLDSEELARIWDTVDTQDR------GY--IDKDEFAVAM------- 362

  Fly   124 GEVEEGWWRGRLRSKVGVFPSNFVQHIEPSPVLASKRPPTIGATVTTSALTSKAANVANVAAT-- 186
             |:.:....|:..:.:..:..|   ..||:.........|..:|....|.|:.  ||:||..:
pombe   363 -EIIKLRLSGKSLASILAYDDN---PTEPTMQQNLVSDDTNASTAVPVAFTND--NVSNVPLSVA 421

  Fly   187 -----------ATVPTGGAVPPA-------STSI--------STSTTKQATKSRATAAAAASAPA 225
                       |:..|....|.|       |:|:        :||...|.:.......|..|...
pombe   422 DNEPNSTLNLLASSDTAAFEPTAVSLHENPSSSLEDLQSAFQNTSFQDQVSTQNQANTADISQNT 486

  Fly   226 EPAAIVSGSGAAAGG---GAAAAVPMLPPKPQREFCRVEFPYAPQNDDELELKVDDIIAVISTEL 287
            |       ||::..|   |.......:|.|      ...|| ...|....::|.::.::..:.:.
pombe   487 E-------SGSSTQGQMFGIPPTTQSIPLK------MAGFP-GGVNSSLTDIKEEEAVSENAPQQ 537

  Fly   288 PDKGWWKGEIRGKVGVFPDNFVKMLAPSEATAAPPLPRPRPRTRPGMGGTGAGSGSGIIDGVRTP 352
            .::.:  .:|:..:.:.|:|    ::..|.:.:.|||.....|.|       ||.|..:|..:|.
pombe   538 EERSF--EQIKTSIHIAPEN----ISAIEESKSVPLPTSFATTIP-------GSTSAALDDQQTT 589

  Fly   353 RRTQRGGSFEFLGARMASFITTIFAPINEP--PSATQITQNQ---RKVSNTASTTSHMTTTNSSN 412
            .                       ||..||  |:.....:.|   ||:.....:|.:...|..::
pombe   590 E-----------------------APFEEPDEPAHEPTEEEQEEMRKLEEKIESTKYGLETIQTS 631

  Fly   413 SSTTSVTTQQQK-------EQIGGSSSTTSKVYIKKTGSSSNSTTSSTTTASSSAGRKESFGSRD 470
            ..|.....:|:|       |::....:...:...:.:.|.......||...|...|:|::
pombe   632 GKTIKQRIEQKKTRLMILREELQELDAIKEEAQKQISQSLIADQQLSTQIGSVGMGKKQA----- 691

  Fly   471 SLNDILSETGLPTGNVAAQRK---SLENKNLDLTKPPGVGASVSIGQQRSSTSSATTSSATTVAT 532
                           |...||   .:::...|...|.|.||..|...:...|.:..|.:.|...
pombe   692 ---------------VKELRKLQAKIDSIIADSMSPMGTGAVNSPAIKPQVTPAPPTPAPTPAV- 740

  Fly   533 GLTSSSVSKSMENMLDEKVKSPPPPVLSK-KPSVPLKKTPTGGVPMTGNLLGGKKKNTEGKLTTA 596
                             |...|||||.|. .||:|       ..|:|
pombe   741 -----------------KHHPPPPPVRSSISPSMP-------PAPLT------------------ 763

  Fly   597 VSHDLADGLAASKMLSGANQLPESGAA---GNVVI---------RRAATIAVEDTDFDRVERASI 649
              |  |:.......:|.....|:|..:   .|.::         |..|.||:|.|::|..|.|:|
pombe   764 --H--ANSSTPMNYVSQPESPPQSYESIQNDNELLQELLSMGFPREKAVIALEATNYDVNEAANI 824

  Fly   650 L 650
            |
pombe   825 L 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cindr	NP_001263129.1	SH3_CD2AP-like_1	6..60	CDD:212806	11/53 (21%)
		SH3_CD2AP-like_2	97..149	CDD:212807	7/51 (14%)
		SH3_CD2AP-like_3	258..310	CDD:212808	7/51 (14%)
ucp8	NP_595633.2	EH	14..80	CDD:238009
		EH	124..223	CDD:197477
		EH	133..204	CDD:238009
		EH	304..370	CDD:238009	14/82 (17%)
		EF-hand_7	305..362	CDD:290234	11/65 (17%)
		UBA	790..826	CDD:197551	12/36 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9305
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000