DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cindr and CD2AP

DIOPT Version :10

Sequence 1:NP_001263129.1 Gene:cindr / 43654 FlyBaseID:FBgn0027598 Length:941 Species:Drosophila melanogaster
Sequence 2:NP_036252.1 Gene:CD2AP / 23607 HGNCID:14258 Length:639 Species:Homo sapiens


Alignment Length:653 Identity:168/653 - (25%)
Similarity:235/653 - (35%) Gaps:183/653 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 IVEYEYAAKEPDELDLQKGAIIHRIKQM-PGGWWQGTLKASGVTGMFPDNFVRVLE--------- 62
            ||||:|.|...|||.::.|.||..:|:: ..||.:|.|  :|..||||||||:.::         
Human     5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGEL--NGRRGMFPDNFVKEIKRETEFKDDS 67

  Fly    63 ---------------SGVSSNGNGTTGSGDHIEVGTAVQLRDKSATSNRRCKVIYSYTQVNDDEL 112
                           ..:|:.|....|...|.:....     |..|..|:|||::.|...|:|||
Human    68 LPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNI-----KKKTKKRQCKVLFEYIPQNEDEL 127

  Fly   113 TLAVGDVIEFLGEVEEGWWRGRLRSKVGVFPSNFVQHIEPSPVLASKRPPTIGATVTTSALTSKA 177
            .|.|||:|:...|||||||.|.|.:|:|:||||||:.:|.:....:........||.... ||..
Human   128 ELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGP-TSPI 191

  Fly   178 ANVANVAATAT-----------VPTGGAVPPASTSISTSTTKQATKSRATAAAAASAPAEPAAIV 231
            .::.||:.||:           :..|......|..:.|.|:...|:.:        .|.:|..:.
Human   192 PSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEK--------KPEKPLILQ 248

  Fly   232 SGSGAAAGGGAAAAVPMLPPKPQ---------------REFCRVEFPYAPQNDDELELKVDDIIA 281
            |                |.||.|               :|:||..|.|...|:|||..|..:||.
Human   249 S----------------LGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIH 297

  Fly   282 VISTELPDKGWWKGEIRGKVGVFPDNFVKML------APSEATAAPPLPRPRPRTR--------- 331
            :||.|..:.|||:||:.||.|||||||...:      .|......||...|.|:..         
Human   298 LISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKDFPKPKKPPPPAKAPAPKPELIAAEKKYF 362

  Fly   332 -------------------------PGMGGTGAGSGSGII--DGVRTPRRTQRGGSFEFLGARMA 369
                                     |....|.....|.::  .|...|:|.::            
Human   363 SLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTKASNLLRSSGTVYPKRPEK------------ 415

  Fly   370 SFITTIFAPINEPPSATQITQNQRKVSNTAST--------TSHMTTTNSSNSSTTSVTTQQQKEQ 426
                    |:..||...:|......:|:...|        .|........:....|:|.:..|| 
Human   416 --------PVPPPPPIAKINGEVSSISSKFETEPVSKLKLDSEQLPLRPKSVDFDSLTVRTSKE- 471

  Fly   427 IGGSSSTTSKVYIKKTGSSSNSTTSSTTTASSSAGRK------ESFGSRDSLNDILSETGLPTGN 485
                   |..|......||.| ....|.......||:      .......|...||.   ||...
Human   472 -------TDVVNFDDIASSEN-LLHLTANRPKMPGRRLPGRFNGGHSPTHSPEKILK---LPKEE 525

  Fly   486 VAAQRKSLENKNLDLTKP-PGVGASVSIGQQRSSTSSATTSSATT---VATGLTSSSVSKSMENM 546
            .:|..|..|.|......| |.|..|..     ||.|.|.|::..|   :...:.:..|.|   |.
Human   526 DSANLKPSELKKDTCYSPKPSVYLSTP-----SSASKANTTAFLTPLEIKAKVETDDVKK---NS 582

  Fly   547 LDE 549
            |||
Human   583 LDE 585

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cindrNP_001263129.1 SH3_CD2AP-like_1 6..60 CDD:212806 26/52 (50%)
SH3_CD2AP-like_2 97..149 CDD:212807 30/51 (59%)
SH3_CD2AP-like_3 258..310 CDD:212808 28/51 (55%)
CD2APNP_036252.1 Interaction with ANLN and localization to the midbody. /evidence=ECO:0000269|PubMed:15800069 1..175 64/176 (36%)
SH3_CD2AP_1 3..58 CDD:212986 26/54 (48%)
SH3_CD2AP_2 111..165 CDD:212987 31/53 (58%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 168..209 8/41 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 227..256 9/52 (17%)
SH3_CD2AP_3 271..327 CDD:212989 29/55 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 333..428 15/114 (13%)
SH3-binding. /evidence=ECO:0000255 336..352 5/15 (33%)
SH3-binding. /evidence=ECO:0000255 378..397 2/18 (11%)
SH3-binding. /evidence=ECO:0000255 410..422 4/31 (13%)

Return to query results.
Submit another query.