Protein Alignment cindr and cdap-2

DIOPT Version :10

• Sequence 1: NP_001263129.1
• Gene: cindr / 43654
• FlyBaseID: FBgn0027598
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: NP_491143.3
• Gene: cdap-2 / 171906
• WormBaseID: WBGene00021549
• Length: 551
• Species: Caenorhabditis elegans
• Alignment Length: 815
• Identity: 181/815 - (22%)
• Similarity: 278/815 - (34%)
• Gaps: 338/815 - (41%)

  Fly   102 YSYTQVNDDELTLAVGDVIEFLGEVEEGWWRGRLRS--KVGVFPSNFVQHIEPSPVLASKRPPTI 164
            |:|:...||||:..|||:||.:.:||:||.:|:|:|  .||:||:|||. ::|:|
 Worm    55 YAYSSKQDDELSFVVGDLIELISDVEDGWSKGKLKSTGAVGMFPTNFVT-LKPTP---------- 108

  Fly   165 GATVTTSALTSKAANVANVAATATVPTGGAVPPASTSISTSTTKQATKSRATAAAAASAPAEPAA 229
                     ::.||.|| .||:|:...|.|....:.||.:....: ::.:|.....::..::||.
 Worm   109 ---------STSAAAVA-PAASASTSAGSAARTPAKSIGSEVVMR-SEPKAIDRTPSTIISDPAP 162

  Fly   230 IVSG-----SGAAAGGGAAAAVPMLPPKPQREFCRVEFPYAPQNDDELELK-VDDIIAVISTELP 288
            ::..     |...|...|:|:......| .:|..||:|.|.||:||||.|| :|.:|.:.:....
 Worm   163 VLKALETKFSSTFASSAASASTDAETTK-TKEMARVKFVYNPQHDDELALKEIDMLINITNKNCG 226

  Fly   289 DKGWWKGEIRGKVGVFPDNFVKMLAPSEATAAPPLPRPRPRTRPGMGGTGAGSGSGIIDGVRTPR 353
            |.||::||:.||.|:||||||:::       ..||            ||.:|:..|.|....|
 Worm   227 DAGWFEGELHGKKGLFPDNFVELV-------QVPL------------GTESGARHGSISRQAT-- 270

  Fly   354 RTQRGGSFEFLGARMASFITTIFAPINEPPSATQITQNQRKVSNTASTTSHMTTTNSSNSSTTSV 418
                           .:|::....|:|.|..|  :.....|:|......|  |...::.|:....
 Worm   271 ---------------LTFVSHKPPPVNPPQPA--VPPKPAKISVADPPPS--TIAPAAPSAPAPA 316

  Fly   419 TTQQQKEQIGGSSSTTSKVYIKKTGSSSNSTTSSTT---TASSSAGRKESFGSRDSLNDILSETG 480
            .:|                        .|.|::|.|   .|.||:..|.:|
 Worm   317 PSQ------------------------LNPTSTSPTMPAIAPSSSALKSNF-------------- 343

  Fly   481 LPTGNVAAQRKSLENKNLDLTKPPGVGASVSIGQQ--RSSTSSATTSSATTVATGLTSSSVSKSM 543
                 .|.|.|.  ::||.:..|..| ||:....|  ||||..:||
 Worm   344 -----AALQEKM--SRNLKVVAPEKV-ASIQKPDQRDRSSTGESTT------------------- 381

  Fly   544 ENMLDEKVKSPPPPVLSKKPSVPLKKTPTGGVPMTGNLLGGKKKNTEGKLTTAVSHDLADGLAAS 608
                                          |.|...|
 Worm   382 ------------------------------GEPSIDN---------------------------- 388

  Fly   609 KMLSGANQLPESGAAGNVVIRRAATIAVEDTDFDRVERASILTDMRQGRVKAPKRRPPSAAINVL 673
               |..:|:.|                              |..:.:.|.:.||.||.|..:|
 Worm   389 ---SATDQVAE------------------------------LQHITKNRARPPKNRPMSMVMN-- 418

  Fly   674 GESNNNSVYVNGSGMSGSGGAGSASELSEDGGAGGKTSDDNSTGEEPQLAKPKPREWEKKKAPWM 738
                                             ..::||::..|   :|:.|
 Worm   419 ---------------------------------RNRSSDESPNG---RLSSP------------- 434

  Fly   739 EELKASQVTRKKTSPS-VEPRGASV-AERTSKLFAAEQAVSSNSSSITTKVQSSAVTSSMFVENS 801
                        ||.| |.|..||: ...|:|    |.::.||||:          |||.|
 Worm   435 ------------TSISTVNPMSASMFVPATAK----EISIPSNSSA----------TSSPF---- 469

  Fly   802 TTSSSVITSSSHTTTNDAIMSRSLSAAKVQTASSDEETRATRPNSLAIRNQRSVSPLVKSSNASS 866
             .|||:...||                     :|....|....||||..:..|.|.:.|.::..|
 Worm   470 -KSSSIAPPSS---------------------ASKPALRPIPSNSLADDSTSSTSAIRKLASPDS 512

  Fly   867 SQSQEEKPTSQLNNHQ-DASSSRVAQLEQRVDKLE 900
            .:|....|:..::..: ||...|...||.||..:|
 Worm   513 QKSPNLPPSDYVSRAEYDALLDRFRALESRVLAIE 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cindr	NP_001263129.1	SH3_CD2AP-like_1	6..60	CDD:212806
		SH3_CD2AP-like_2	97..149	CDD:212807	25/48 (52%)
		SH3_CD2AP-like_3	258..310	CDD:212808	27/52 (52%)
cdap-2	NP_491143.3	SH3	53..104	CDD:473055	25/49 (51%)
		SH3	194..249	CDD:473055	28/54 (52%)