DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cindr and Cd2ap

DIOPT Version :9

Sequence 1:	NP_001263129.1	Gene:	cindr / 43654	FlyBaseID:	FBgn0027598	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_033977.3	Gene:	Cd2ap / 12488	MGIID:	1330281	Length:	637	Species:	Mus musculus

Alignment Length:	613	Identity:	151/613 - (24%)
Similarity:	238/613 - (38%)	Gaps:	172/613 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IVEYEYAAKEPDELDLQKGAIIHRIKQM-PGGWWQGTLKASGVTGMFPDNFVRVLE--------- 62
            ||||:|.|...|||.::.|.||..:|:: ..||.:|.|  :|..||||||||:.::
Mouse     5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGEL--NGRRGMFPDNFVKEIKRETEPKDDN 67

  Fly    63 ---------------SGVSSNGNGTTGSGDHIEVGTAVQLRDKSATSNRRCKVIYSYTQVNDDEL 112
                           ..:|:.|....|...|.:....     |..|..|:|||::.|:..|:|||
Mouse    68 LPIKRERQGNVASLVQRISTYGLPAGGIQPHPQTKAI-----KKKTKKRQCKVLFDYSPQNEDEL 127

  Fly   113 TLAVGDVIEFLGEVEEGWWRGRLRSKVGVFPSNFVQHIEPS---PVLASKRPPTIGATVTTSALT 174
            .|.|||||:.:.|||||||.|.|.:|:|:||||||:.:|.:   ....::....:..|..||.|.
Mouse   128 ELIVGDVIDVIEEVEEGWWSGTLNNKLGLFPSNFVKELESTEDGETHNAQEESEVPLTGPTSPLP 192

  Fly   175 SKA-------ANVANVAATATVPTGGAVPPASTSISTSTTKQATKSRATAAAAASAPAEPAAIVS 232
            |..       .:||.......:..|......|..:.|.|:...|:.:.|.......|.
Mouse   193 SPGNGSEPAPGSVAQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKTEKPLILQPL------- 250

  Fly   233 GSGAAAGGGAAAAVPMLPPK-----PQREFCRVEFPYAPQNDDELELKVDDIIAVISTELPDKGW 292
                   |.....|.:..|.     ..:|:||..|||...|:|||..:..:||.:||.|..:.||
Mouse   251 -------GSRTQNVEVTKPDVDGKIKAKEYCRTLFPYTGTNEDELTFREGEIIHLISKETGEAGW 308

  Fly   293 WKGEIRGKVGVFPDNFVKMLA------PSEATAAPPLPRPRPRTR-------------------- 331
            ||||:.||.|||||||...::      |......||...|.|:..
Mouse   309 WKGELNGKEGVFPDNFAVQISELDKDFPKPKKPPPPAKGPAPKPDLSAAEKKAFPLKAEEKDEKS 373

  Fly   332 --------------PGMGGTGAGSGSGII--DGVRTPRRTQR-----------GGSFEFLGARMA 369
                          |....|.....|.::  .|...|:|.::           .|....:.:::.
Mouse   374 LLEQKPSKPAAPQVPPKKPTAPTKASNLLRSPGAVYPKRPEKPVPPPPPAAKINGEVSIISSKID 438

  Fly   370 SFITTIFAPINEP----------PSATQ----ITQNQRKVSNT-----ASTTS--HMTTT----- 408
            :      .|:::|          |.:..    :.:|.::..:.     ||:.:  |:|..
Mouse   439 T------EPVSKPKLDPEQLPVRPKSVDLDAFVARNSKETDDVNFDDIASSENLLHLTANRPKMP 497

  Fly   409 --------NSSNSSTTS--VTTQQQKEQIGGSSSTTSKVYIKKTGSSSNSTTSSTTTASS----- 458
                    |..:|.|.|  .|.:..||.   .|.....:..||..|.|:.::.||.:::|
Mouse   498 GRRLPGRFNGGHSPTQSPEKTLKLPKED---DSGNLKPLEFKKDASYSSKSSLSTPSSASKVNTA 559

  Fly   459 --------SAGRKESFGSRDSLNDILSE 478
                    .|..:...|.|:|::::.::
Mouse   560 AFLTPLELKAKAEADDGKRNSVDELRAQ 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cindr	NP_001263129.1	SH3_CD2AP-like_1	6..60	CDD:212806	26/52 (50%)
		SH3_CD2AP-like_2	97..149	CDD:212807	31/51 (61%)
		SH3_CD2AP-like_3	258..310	CDD:212808	29/51 (57%)
Cd2ap	NP_033977.3	Interaction with ANLN and localization to the midbody. /evidence=ECO:0000250	1..175		65/176 (37%)
		SH3_CD2AP_1	3..58	CDD:212986	26/54 (48%)
		SH3_CD2AP_2	111..165	CDD:212987	32/53 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..209		8/42 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..254		6/41 (15%)
		SH3_CD2AP_3	271..327	CDD:212989	30/55 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..455		14/127 (11%)
		SH3-binding. /evidence=ECO:0000255	336..352		5/15 (33%)
		SH3-binding. /evidence=ECO:0000255	378..397		2/18 (11%)
		SH3-binding. /evidence=ECO:0000255	410..422		2/11 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..555		16/69 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831443
Domainoid	1	1.000	71	1.000	Domainoid score	I9408
eggNOG	1	0.900	-	-		E1_KOG4348
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1577081at2759
OrthoFinder	1	1.000	-	-		FOG0002275
OrthoInspector	1	1.000	-	-		otm43633
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14167
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5319
SonicParanoid	1	1.000	-	-		X1165
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.840