DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wts and LATS1

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	XP_016866963.1	Gene:	LATS1 / 9113	HGNCID:	6514	Length:	1163	Species:	Homo sapiens

Alignment Length:	1114	Identity:	469/1114 - (42%)
Similarity:	558/1114 - (50%)	Gaps:	337/1114 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 SGAGSSRSDSPHSH----------HTHQPSSRT-VGNPGGNGGFS---------------PSPSG 189
            |..||..|..|..|          |:..|:|:| ||.|....|.|               |.|..
Human   177 SWKGSKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPPQ 241

  Fly   190 FSEVAPPAPPPRNPTACSAATPPPPV--PPTSQA--------YVKRR--------------SPAL 230
            ...|.|| ||||..|.....|.|||.  .|.||.        ||..|              .|.|
Human   242 VRSVTPP-PPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPL 305

  Fly   231 NNRPPAIAPPTQR---------GNSPVITQN-----------GLKNPQQQLTQQLKSLNLYPGGG 275
            |..|  :.||.|.         |..|:|.|:           |::|...| |..:...|:.|.|.
Human   306 NTSP--MNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQNGTGQ-TDFMIHQNVVPAGT 367

  Fly   276 SGAVVEPPPPYLIQGGAGGAAP-------PPPPPSYT--ASMQSRQSPT---------------- 315
            ...  :|||||.:. .|.|.:|       ...|.|||  :..||...|.
Human   368 VNR--QPPPPYPLT-AANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNMELYNISVPGL 429

  Fly   316 -----QSQQSDYRKSPSSG-------------------------IYSATSAGSPSPITVSLPPAP 350
                 ||..:..:.|||||                         .:||.|..|.:.:| ::.|||
Human   430 QTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQPSATTVT-AITPAP 493

  Fly   351 LAKPQPRVYQARSQQPIIMQSVKSTQVQKPVLQTAVAPQSPSSASASNSPVHVLAAPPSYPQKSA 415
            :            |||     |||.:|.||.||||:||..||...   .|:..: .|..:|:.:|
Human   494 I------------QQP-----VKSMRVLKPELQTALAPTHPSWIP---QPIQTV-QPSPFPEGTA 537

  Fly   416 AVVQQQQQAAAAAHQQQHQHQQSKPPTPTTPPLVGLNSKPNCLEPPSYAKSMQAKAATVVQQQQQ 480
            :.|...                  ||....|...|        .||.|.|
Human   538 SNVTVM------------------PPVAEAPNYQG--------PPPPYPK--------------- 561

  Fly   481 QQQQQQQVQQQQVQQQQQQQQQQLQALRVLQAQAQRERDQRERDQRERERDQQKLANGNPGRQML 545
                                                                 .|.:.||.
Human   562 -----------------------------------------------------HLLHQNPS---- 569

  Fly   546 PPPPYQSNNNNNSEIKPPSCNNNNIQISNSNLATTPPIPPAKYNNNSSNTGANSSGGSNGSTGTT 610
             .|||:|.:..:.|.:|.....:..:.|..|:                     .||.......||
Human   570 -VPPYESISKPSKEDQPSLPKEDESEKSYENV---------------------DSGDKEKKQITT 612

  Fly   611 ASSSTSCKKIKHASPIPERKKISKEKEEERKEFRIRQYSPQAFKFFMEQHIENVIKSYRQRTYRK 675
                         |||..||   .:|:|||:|.||:.|||||||||||||:|||:||::||.:||
Human   613 -------------SPITVRK---NKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRK 661

  Fly   676 NQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGEVTLVSKID 740
            .|||.||.:|||....|.:|||||.|||||||||||||||||||||:|.:|:||||||.|..|:|
Human   662 KQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVD 726

  Fly   741 TSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDL 805
            | ..|||.|||||.|||.|||||||||||||||||||.|||:||||||||||||||||||||||:
Human   727 T-KALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDM 790

  Fly   806 MSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRW 870
            |||||::|||.|.||||||||:||||:||||||||||||||||||||||||||||||||||||||
Human   791 MSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRW 855

  Fly   871 THNSKYYQENGNHSRQDSMEPWEEYSEN-----GPKPTVLERRRMRDHQRVLAHSLVGTPNYIAP 930
            ||:||||| :|:|.|||||:...|:.:.     |.:...||||..|.|||.||||||||||||||
Human   856 THDSKYYQ-SGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAP 919

  Fly   931 EVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQK----------------------- 972
            |||.|:|||||||:|||||||:|||||||||||.:|||||.|
Human   920 EVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKPGMVAHTCNPSALEGHSRKNTGT 984

  Fly   973 ----------VINWEKTLHIPPQAELSREATDLIRRLCASADKRLGKS-VDEVKSHDFFKGIDF- 1025
                      ||||:.:|||||||:||.||:|||.:||...:.||||: .||:|:|.|||.|||
Human   985 QEFEIGLGNIVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFS 1049

  Fly  1026 ADMRKQKAPYIPEIKHPTDTSNFDPVDPEKLRSNDSTMSSGDDV-----DQNDRTFHGFFEFTFR 1085
            :|:|:|.|.|||:|.|||||||||||||:||.|:|:...:.:|.     .......|.|:|||||
Human  1050 SDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTFR 1114

  Fly  1086 RFFDDKQPP 1094
            |||||...|
Human  1115 RFFDDNGYP 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	264/405 (65%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	230/339 (68%)
LATS1	XP_016866963.1	UBA_LATS1	103..143	CDD:270580
		FtsK	<448..>596	CDD:332908	48/268 (18%)
		PKc_like	703..1117	CDD:328722	272/415 (66%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141875
Domainoid	1	1.000	163	1.000	Domainoid score	I3965
eggNOG	1	0.900	-	-		E1_KOG0608
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	699	1.000	Inparanoid score	I679
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	1	1.000	-	-		FOG0000273
OrthoInspector	1	1.000	-	-		oto88335
orthoMCL	1	0.900	-	-		OOG6_105652
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4821
SonicParanoid	1	1.000	-	-		X2473
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790