DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wts and STE20

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_011856.1	Gene:	STE20 / 856382	SGDID:	S000000999	Length:	939	Species:	Saccharomyces cerevisiae

Alignment Length:	1153	Identity:	238/1153 - (20%)
Similarity:	383/1153 - (33%)	Gaps:	384/1153 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 PPAIVGQPGAGSI----------SVSGVGVGVVGVANGRVPKMMTALMPNKLIRKPSIERDTASS 140
            |.|:...|...|:          ::.|.|.|..|:   |:|:....|..|      ::::.|.::
Yeast     5 PSAVSELPDKDSLDNGISNDNERAMGGNGDGGDGL---RLPRTTGTLNVN------ALQKGTNAA 60

  Fly   141 H----YLRCSPA---------------LDSG------------AGSSRSDSPHSHHTHQPSSRTV 174
            |    |....||               ||..            :|.|.|.||||:.....|...|
Yeast    61 HEAGGYKSMDPAKNAETTNDDDNNVVSLDDPIQFTRVSSSSVISGMSSSMSPHSNIDETKSLEAV 125

  Fly   175 GNPGGNGGFSPSPSG---FSEV-APPAPPPRNPTACSAATPPPPVPP-TSQAYVKRRSPALNNRP 234
            .........:|..|.   ||.: |..:....|.|..|..:....... .:.|.||.:.|
Yeast   126 TPNINTSNITPDHSADNTFSTINASESDHQFNDTLLSKLSLTDSTETIENNATVKHQQP------ 184

  Fly   235 PAIAPPTQRGN-------------SPVITQNGLKNPQQQLTQQLKSLNLYPGGGSGAVVEPPPPY 286
              :|..|...|             :|||::..:....:|:.....||:..........|:|..|
Yeast   185 --VASSTVNSNKSSTDIRRATPVSTPVISKPSMTTTPRQINSASHSLSNPKHKQHKPKVKPSKP- 246

  Fly   287 LIQGGAGGAAPPPPPPSYTASMQSR-----QSPTQSQ-QSDYRKSPSSGIYSATSAGSPSPITVS 345
                     .....|.|...|..|:     .||.:.| :..|..|.|....|.:::|:
Yeast   247 ---------EAKSKPVSVKKSFPSKNPLKNSSPPKKQTEKSYYSSSSKKRKSGSNSGT------- 295

  Fly   346 LPPAPLAKPQPRVYQARSQQPIIMQSVKSTQVQ--KPVLQTAVAPQSPSSASASNSPVHVLAAPP 408
                                 :.|:.|.::.||  |...|......|.|:.|:|:|....|....
Yeast   296 ---------------------LRMKDVFTSFVQNIKRNSQDDKRASSSSNNSSSSSITTALRIST 339

  Fly   409 SYPQKSAAVVQQQQQAAAAAHQQQHQHQQSKPPTPTTPPLVGLNSKPNCLE--PPSYAKSMQAKA 471
            .|..|                   |.|.            ||::||.....  |..:.|.:.:..
Yeast   340 PYNAK-------------------HIHH------------VGVDSKTGEYTGLPEEWEKLLTSSG 373

  Fly   472 ATVVQQQQQQQQQQQQVQQQQVQQQQQQQQQQLQALRVLQAQAQRERDQRERDQRERERDQQKLA 536
            .:..:|||..|.....|:..|                          |..|.:..::........
Yeast   374 ISKREQQQNMQAVMDIVKFYQ--------------------------DVTETNGEDKMFKTFNTT 412

  Fly   537 NGNPGRQMLPPPPYQSNNNNNSEIKPPSCNNNNIQISN-----SNLATTPPIPPAKYNNNSSNTG 596
            .|.||...:..||..|.|.     .|||.::::...|.     ||...:|.:          ||.
Yeast   413 TGLPGSPQVSTPPANSFNK-----FPPSTSDSHNYGSRTGTPMSNHVMSPTL----------NTD 462

  Fly   597 ANSSGG----SNGSTGTTASSSTSCKKIK--------HASPI-------------PERKKISKEK 636
            ::|:.|    |..:....:|:|.|...||        :.||:             |.|..||:..
Yeast   463 SSSANGKFIPSRPAPKPPSSASASAPIIKSPVMNSAANVSPLKQTHAPTTPNRTSPNRSSISRNA 527

  Fly   637 EEERKEFRIRQYSPQAFK-------FFMEQHIENVIKSYRQRTYRKNQLEKEMHKVGLPDQTQIE 694
            ..:::|..:....|...|       ....|.:....|:..|.|            |..|.....:
Yeast   528 TLKKEEQPLPPIPPTKSKTSPIISTAHTPQQVAQSPKAPAQET------------VTTPTSKPAQ 580

  Fly   695 MR---KMLNQKESNYIRLKRAKMDKSMFVKLK----------------PIGVGAFGEVTLVSKID 740
            .|   |.||:|:    |.:|.:..|.::.||.                .||.||.|.|....:|.
Yeast   581 ARSLSKELNEKK----REERERRKKQLYAKLNEICSDGDPSTKYANLVKIGQGASGGVYTAYEIG 641

  Fly   741 TSNHLYAMKTLRKADVLKR----NQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIP 801
            | |...|:|.:......|:    |::..:|..:       :..:|....|:..|.:|:.:|:|:.
Yeast   642 T-NVSVAIKQMNLEKQPKKELIINEILVMKGSK-------HPNIVNFIDSYVLKGDLWVIMEYME 698

  Fly   802 GGDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCT 866
            ||.|..::....:.|.::.. ...|....::.:|..|.:|||||.||||:..:|.|||||||.|.
Yeast   699 GGSLTDVVTHCILTEGQIGA-VCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCA 762

  Fly   867 GFRWTHNSKYYQENGNHSRQDSMEPWEEYSENGPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPE 931
                                       :.:|...|.|                ::||||.::|||
Yeast   763 ---------------------------QINELNLKRT----------------TMVGTPYWMAPE 784

  Fly   932 VLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPL---------------------ETQQKVIN 975
            |:.|..|....|.||:|:::.||:.|:||:|..:||                     .:.:|.::
Yeast   785 VVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENLSSSLKKFLD 849

  Fly   976 WEKTLHIPPQAELSREATDLIRRLCASADKRLGKSVDEVKSHDFFKGIDFADMRKQKAPYI--PE 1038
            |  .|.:.|:...|  ||:|:                    ||.:. .:.|:.....||.:  ..
Yeast   850 W--CLCVEPEDRAS--ATELL--------------------HDEYI-TEIAEANSSLAPLVKLAR 889

  Fly  1039 IKH-----PTDTSNFDPVDPEKLR-------SNDSTMSSGDDVDQNDR 1074
            :|.     ..|..|.|..|.|.:.       :|||..:...||.::|:
Yeast   890 LKKVAENMDADEDNDDDNDNEHINKTNNCDDNNDSKETVNLDVTEDDK 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	97/413 (23%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	82/341 (24%)
STE20	NP_011856.1	PBD	336..394	CDD:395634	15/88 (17%)
STE20	NP_011856.1	STKc_PAK	619..872	CDD:270789	80/329 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000