DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wts and FPK1

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_014445.1	Gene:	FPK1 / 855783	SGDID:	S000005330	Length:	893	Species:	Saccharomyces cerevisiae

Alignment Length:	960	Identity:	222/960 - (23%)
Similarity:	370/960 - (38%)	Gaps:	265/960 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 SPVITQNGLKNPQQQLTQQLKSLNLYPGGGSGAVVEPPPPYLIQGGAGGAAPPPPPPSYTASMQS 310
            |.::|::..:|........:.|:|||
Yeast    39 SKLLTRSWKRNASSSNNMSVSSVNLY--------------------------------------- 64

  Fly   311 RQSPTQSQQSDYRKSPSSG-------IYSATSAGSPSPITVSLPPAPLAKPQPRVYQARSQQPII 368
             ..|..|::||:..|.|.|       :.|...:|:.|....:              ...||..:.
Yeast    65 -SDPENSRESDHNNSGSEGQSSRFSKLKSMFQSGNSSKNASA--------------HNSSQSSLE 114

  Fly   369 MQSVKST---QVQKPVLQTAVAPQSPSSASASNSPVHVLAAPPSYPQKSAAVVQQQQQAAAAAHQ 430
            ..|..|:   :..||:  |:||..||:|...|          |:.|:....      |.....|.
Yeast   115 GDSASSSSKLRYVKPM--TSVANASPASPPLS----------PTIPETDVL------QTPKMVHI 161

  Fly   431 QQHQHQQ--------------SKPPT-----------PTTPPLVGLN----SKPNCLEPPSYA-- 464
            .||:|::              |..||           |:||.:...|    |..:.:.|.:|.
Yeast   162 DQHEHEREHSNCGSPIMLSSSSFSPTVARTGTGRRRSPSTPIMPSQNSNNSSSTSAIRPNNYRHH 226

  Fly   465 ---------KSMQAKAATV---------------------VQQQQQQQQQQQQVQQQQVQQQQQQ 499
                     ...:.:|.||                     :.:..|.......:........:..
Yeast   227 SGSQGFSSNNPFRERAGTVRSSNPYFAYQGLPTHAMSSHDLDEGFQPYANGSGIHFLSTPTSKTN 291

  Fly   500 QQQQLQALRVLQAQAQRERDQRERDQRE--------RERDQQKLANGNPGRQMLPPP-------- 548
            .....:.|..|.....:|.::.:....|        ::...:...||:|.|.....|
Yeast   292 SLTNTKNLSNLSLNEIKENEEVQEFNNEDFFFHDIPKDLSLKDTLNGSPSRGSSKSPTITQTFPS 356

  Fly   549 -------PYQSNNNNNSEIKPPSCNNNNIQISNSNLATTPPIPPAKYNNNSSN--------TGAN 598
                   .|:.:|||:...:     ....|.:..|  .|..:.|.|.|..:::        ..|:
Yeast   357 IIVGFDNEYEEDNNNDKHDE-----KEEQQTTTDN--KTRNLSPTKQNGKATHPRIKIPLRRAAS 414

  Fly   599 SSGGSNGSTGTTASSSTSCKKIKHASPIPERKKISKEKEEERKEFRIRQYSPQAFKFFMEQHIEN 663
            ...|...::.|:.:|| |.:|...:|.|.:  ||..:.......|..::.||:         |.:
Yeast   415 EPNGLQLASATSPTSS-SARKTSGSSNIND--KIPGQSVPPPNSFFPQEPSPK---------ISD 467

  Fly   664 VIKSYRQRTYRKNQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLKPIGVG 728
            ..:..|.|..|......:...:.:..|:                           |.|::.:|.|
Yeast   468 FPEPRRSRRLRTKSFSNKFQDIMVGPQS---------------------------FEKIRLLGQG 505

  Fly   729 AFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNL 793
            ..|:|.||.:..| |.:||:|.|.|.:::|||::..|..|::|||.:::.::|.||:|||.:|.|
Yeast   506 DVGKVFLVREKKT-NRVYALKVLSKDEMIKRNKIKRVLTEQEILATSNHPFIVTLYHSFQSEDYL 569

  Fly   794 YFVMDYIPGGDLMSLL--IKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGH 856
            |..|:|..||:....|  .|.....|:.||||.:|||.|::.:|.:|||:||:||:|||:.:.||
Yeast   570 YLCMEYCMGGEFFRALQTRKTKCICEDDARFYASEVTAALEYLHLLGFIYRDLKPENILLHQSGH 634

  Fly   857 IKLTDFGLCTGFRWTHNSKYYQENGNHSRQDSMEPWEEYSENGPKPTVLERRRMRDHQRVLAHSL 921
            |.|:||.|                 :...:||..|   ..:...:.|:::.:...|..|  .:|.
Yeast   635 IMLSDFDL-----------------SIQAKDSKVP---VVKGSAQSTLVDTKICSDGFR--TNSF 677

  Fly   922 VGTPNYIAPEVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQA 986
            |||..||||||:..:|:|...|:|::|:::||||.|..||..::..||...::..|  :..|...
Yeast   678 VGTEEYIAPEVIRGNGHTAAVDWWTLGILIYEMLFGFTPFKGDNTNETFTNILKNE--VSFPNNN 740

  Fly   987 ELSREATDLIRRLCA-SADKRLG--KSVDEVKSHDFFKGIDFADMRKQKAPYIPEIKHPTDTSNF 1048
            |:||...|||::|.. :..||||  ....:||.|.|||.:.::.:|.|:.|.||.:..
Yeast   741 EISRTCKDLIKKLLTKNESKRLGCKMGAADVKKHPFFKKVQWSLLRNQEPPLIPVLSE------- 798

  Fly  1049 DPVDPEKLRSNDSTMSSGDD---VDQNDRTFHGFFEFTFRRFFDDKQPPD 1095
            |..|..||.||....:|.|.   :|:.::..     |..|..:||:...|
Yeast   799 DGYDFAKLSSNKKRQTSQDSHKHLDEQEKNM-----FEERVEYDDEVSED 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	128/368 (35%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	111/305 (36%)
FPK1	NP_014445.1	STKc_phototropin_like	494..797	CDD:270726	120/354 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910