DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wts and DBF2

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_011606.3	Gene:	DBF2 / 852984	SGDID:	S000003324	Length:	572	Species:	Saccharomyces cerevisiae

Alignment Length:	577	Identity:	179/577 - (31%)
Similarity:	268/577 - (46%)	Gaps:	119/577 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   546 PPP------PYQSNNNNN-SEIKPPSCNNNNIQISNSNLATTPPIPPAKYNNNSSNTGANSSGGS 603
            |.|      ||:..:|.: .|:..|     ::.:|||    ...:||..|...:||
Yeast    52 PSPVKPSFFPYEDTSNMDIDEVSQP-----DMDVSNS----PKKLPPKFYERATSN--------- 98

  Fly   604 NGSTGTTASSSTSCKKIKHASPIPERKKISKEKEEERKEFRIRQYSPQAFKFFMEQHIE--NVIK 666
                 .|....:.||                                   .:|:|.:.:  :.:.
Yeast    99 -----KTQRVVSVCK-----------------------------------MYFLEHYCDMFDYVI 123

  Fly   667 SYRQRTYRKNQLEKEMHKVGLPDQTQIEMRKMLN---QKESNYIRLKRAKMDKSMFVKLKPIGVG 728
            |.||||  |..||....:..||:..||::.:..:   |:|...:|.:|.|.....|..:..:|.|
Yeast   124 SRRQRT--KQVLEYLQQQSQLPNSDQIKLNEEWSSYLQREHQVLRKRRLKPKNRDFEMITQVGQG 186

  Fly   729 AFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNL 793
            .:|:|.|..|.|| ..:.|:|.|.|..:.|.|:..||..|||||....:.|:|||.|:|||..:|
Yeast   187 GYGQVYLARKKDT-KEVCALKILNKKLLFKLNETKHVLTERDILTTTRSEWLVKLLYAFQDLQSL 250

  Fly   794 YFVMDYIPGGDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIK 858
            |..|:::||||..:|||.....:...|||||:|:.|||:::|.:|:.|||:||:|.|||..||||
Yeast   251 YLAMEFVPGGDFRTLLINTRCLKSGHARFYISEMFCAVNALHDLGYTHRDLKPENFLIDAKGHIK 315

  Fly   859 LTDFGLCTGFRWTHNSKYYQENGNHSRQDSME---------PWEEYSENGPKPTVLERRRM---- 910
            ||||||..|            ..::.|.:||:         .:..::|.    ::.:||:|
Yeast   316 LTDFGLAAG------------TISNERIESMKIRLEKIKDLEFPAFTEK----SIEDRRKMYNQL 364

  Fly   911 RDHQRVLAHSLVGTPNYIAPEVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVIN 975
            |:.:...|:|:||:|:|:|.||||...|....||||:|.:|:|.|||..||..:|..||...:..
Yeast   365 REKEINYANSMVGSPDYMALEVLEGKKYDFTVDYWSLGCMLFESLVGYTPFSGSSTNETYDNLRR 429

  Fly   976 WEKTLHIPPQ----AELSREATDLIRRLCASADKRLGKSVDEVKSHDFFKGIDFADMRKQKAPYI 1036
            |::||..|.|    |..|....|||.||.|....|| :|.:.||...:|..|:|:.:|....|:.
Yeast   430 WKQTLRRPRQSDGRAAFSDRTWDLITRLIADPINRL-RSFEHVKRMSYFADINFSTLRSMIPPFT 493

  Fly  1037 PEIKHPTDTSNFDPVDPEK--------LRSNDSTMSSGDDVDQNDRTFHGFFEFTFR 1085
            |::...||...||....|.        .:..|...:..||...:.:    ...||||
Yeast   494 PQLDSETDAGYFDDFTSEADMAKYADVFKRQDKLTAMVDDSAVSSK----LVGFTFR 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	138/385 (36%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	124/317 (39%)
DBF2	NP_011606.3	STKc_Sid2p_like	165..547	CDD:270751	145/404 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344969
Domainoid	1	1.000	215	1.000	Domainoid score	I480
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840