DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wts and RIM15

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_116620.1	Gene:	RIM15 / 850511	SGDID:	S000001861	Length:	1770	Species:	Saccharomyces cerevisiae

Alignment Length:	917	Identity:	205/917 - (22%)
Similarity:	350/917 - (38%)	Gaps:	276/917 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   354 PQPRVYQARSQQP----IIMQSVKSTQVQKPVLQTAVAPQS--------PSSASASNSPVHVLAA 406
            |.|:::   ||||    :|..|....|||.....:..||..        |.|:.......:.:..
Yeast   477 PLPQIH---SQQPEAENLIYSSSTPLQVQHDQCASFEAPSKSHLEPIPFPVSSIEETPTANDIRH 538

  Fly   407 PPSYPQKSAAVVQQ----QQQAAAAAHQQQHQHQQSKPPTPTTPPLVGL------NSKPNCLEPP 461
            |...|:..:..|.:    :::..:..............|.|:....:.:      ||:.:.::
Yeast   539 PSPLPRSCSNTVMKLPTPRRKLDSNGLFSDAYLNADIIPNPSIESTISIDRDNNTNSRGSSMK-- 601

  Fly   462 SYAKSMQAKAATVVQQQQQQQQQQQQVQQQQVQQQQQQQQQQLQALRVLQAQAQRERDQRERDQR 526
            .|.......:.|...::......:..::.:.:..:|:.:...:            :.|.|..:..
Yeast   602 QYGIGEATDSRTSNSERPSSSSSRLGIRSRSITPRQKIEYSHV------------DNDDRTNEML 654

  Fly   527 ERERDQQKLANGNPGRQMLPPPPYQSNNNNNSEIKPPSCNNNNIQISNS---NLATTPPIPPAKY 588
            .|::|           .:.|.|...:...::::........|:...:||   .|.|:..:.|.:.
Yeast   655 SRDKD-----------SLQPQPSVDTTITSSTQATTTGTKTNSNNSTNSVLPKLMTSISLTPRRG 708

  Fly   589 NNNSSNTGANSSGGSNGSTGTTASSSTSCKKIKHASPIPERKKISKEKEEERKEFRIRQYSPQAF 653
            :.:..|..::|...:|           |.|.|...|||.                     ||..|
Yeast   709 SPSFGNLASHSMQQTN-----------SFKLIHDKSPIS---------------------SPFTF 741

  Fly   654 -KFFM--EQHIENVIKSYRQRTYRKNQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMD 715
             |.|:  |||..|:.        |.:.:...|  :..|:.....:....||      .:|.....
Yeast   742 SKDFLTPEQHPSNIA--------RTDSINNAM--LTSPNMPLSPLLLATNQ------TVKSPTPS 790

  Fly   716 KSMFVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDI-LAEADNNW 779
            ...:..||||..||:|.|.|..|..|.:: :|:|.|||:|::.:|||.:||:||.| :.::|..:
Yeast   791 IKDYDILKPISKGAYGSVYLARKKLTGDY-FAIKVLRKSDMIAKNQVTNVKSERAIMMVQSDKPY 854

  Fly   780 VVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDI 844
            |.:|:.|||:||||:.||:|:|||||.:|:..:|...::.|:.|:.|:...|:.:|:.|.||.|:
Yeast   855 VARLFASFQNKDNLFLVMEYLPGGDLATLIKMMGYLPDQWAKQYLTEIVVGVNDMHQNGIIHHDL 919

  Fly   845 KPDNILIDRDGHIKLTDFGL-----------------------------CTGFRWTHNSKYYQE- 879
            ||:|:|||..||:|||||||                             ...|...:|:..:.:
Yeast   920 KPENLLIDNAGHVKLTDFGLSRAGLIRRHKFVPHKSSLSISSTLPIDNPANNFTMNNNNSNHSQL 984

  Fly   880 -----------NGNHSRQDSMEPWEEYSENG---------PKPTV-------------------- 904
                       ..|.|::.|:....|:||..         |.|:.
Yeast   985 STPDSFTSDHKQYNRSKKSSLGQQYEHSEYSSTSNSHSMTPTPSTNTVVYPSYYRGKDRSHGSSN 1049

  Fly   905 ---------------------------------------LERRRMRDHQRVLAHSLV-------- 922
                                                   :.||:.....:..::.|:
Yeast  1050 IDLPASLRRSESQLSFSLLDISRSSTPPLANPTNSNANNIMRRKSLTENKSFSNDLLSSDAIAAT 1114

  Fly   923 ----------------------------------GTPNYIAPEVLERSGY-TQLCDYWSVGVILY 952
                                              |||:|:|||.:|..|. .:.||:||||.|.:
Yeast  1115 NTNINSNNNISLSPAPSDLALFYPDDSKQNKKFFGTPDYLAPETIEGKGEDNKQCDWWSVGCIFF 1179

  Fly   953 EMLVGQPPFLANSPLETQQK----VINWEKTLHIPPQAE-LSREATDLIRR-LCASADKRLG-KS 1010
            |:|:|.|||.|.:|....:|    ||.|.:..:...:.| |:.||.|||.: |.....|||| |.
Yeast  1180 ELLLGYPPFHAETPDAVFKKILSGVIQWPEFKNEEEEREFLTPEAKDLIEKLLVVDPAKRLGAKG 1244

  Fly  1011 VDEVKSHDFFKGIDFADMRKQKAPYIPEIKHPTDTSNFDPVDPEKLRSNDSTMSSGDDVDQNDRT 1075
            :.|:|.|.:||.:|:..:..::|.::|.|.:|.||..||      ||..: ....|||::.::..
Yeast  1245 IQEIKDHPYFKNVDWDHVYDEEASFVPTIDNPEDTDYFD------LRGAE-LQDFGDDIENDNAN 1302

  Fly  1076 F----HG 1078
            .    ||
Yeast  1303 ILFGKHG 1309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	142/524 (27%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	126/460 (27%)
RIM15	NP_116620.1	PKc_like	797..1260	CDD:419665	129/463 (28%)
		S_TK_X	1255..>1298	CDD:214529	15/49 (31%)
		REC_hyHK_CKI1_RcsC-like	1637..1746	CDD:381099
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000273
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910