DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wts and Rock1

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_001376168.1	Gene:	Rock1 / 81762	RGDID:	620424	Length:	1354	Species:	Rattus norvegicus

Alignment Length:	416	Identity:	154/416 - (37%)
Similarity:	229/416 - (55%)	Gaps:	63/416 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   695 MRKMLNQKESNYI--------RLKRAKMDKSMFVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTL 751
            :||  |:...|::        :::..:|....:..:|.||.||||||.|| :..::..:||||.|
  Rat    46 LRK--NKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLV-RHKSTRKVYAMKLL 107

  Fly   752 RKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLGIFE 816
            .|.:::||:..|....||||:|.|::.|||:|:|:|||...||.||:|:|||||::|:....: .
  Rat   108 SKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-P 171

  Fly   817 EELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHNSKYYQENG 881
            |:.||||.|||..|:|::|.|||||||:||||:|:|:.||:||.|||.|
  Rat   172 EKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTC---------------- 220

  Fly   882 NHSRQDSMEPWEEYSENGPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPEVLERSG----YTQLC 942
                                      .:|.....|...:.||||:||:||||:..|    |.:.|
  Rat   221 --------------------------MKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGREC 259

  Fly   943 DYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREATDLIRRLCASADKRL 1007
            |:|||||.|||||||..||.|:|.:.|..|::|.:.:|..|...::|:||.:||.......:.||
  Rat   260 DWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRL 324

  Fly  1008 GKS-VDEVKSHDFFKGIDFA--DMRKQKAPYIPEIKHPTDTSNFDPVDPEKLRSNDSTMSSGDDV 1069
            |:: |:|:|.|.|||...:|  .:|...||.:|::....||||||.::.:|  .::.|.......
  Rat   325 GRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDK--GDEETFPIPKAF 387

  Fly  1070 DQNDRTFHGFFEFTFRRFFDDKQPPD 1095
            ..|...|.||..::.||:.....|.:
  Rat   388 VGNQLPFVGFTYYSNRRYLPSANPSE 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	144/367 (39%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	126/305 (41%)
Rock1	NP_001376168.1	STKc_ROCK1	2..406	CDD:270772	153/407 (38%)
		Interaction with FHOD1. /evidence=ECO:0000250	368..727		11/48 (23%)
		SMC_prok_B	426..>1097	CDD:274008
		HR1_ROCK1	489..554	CDD:212029
		SHROOM3 binding. /evidence=ECO:0000250\|UniProtKB:Q13464	707..946
		ROCK_SBD	836..913	CDD:409019
		RHOA binding. /evidence=ECO:0000250	998..1010
		PH_ROCK	1119..1225	CDD:269948
		C1_ROCK1	1222..1290	CDD:410424
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920