DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wts and RPS6KA3

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	XP_011543857.1	Gene:	RPS6KA3 / 6197	HGNCID:	10432	Length:	746	Species:	Homo sapiens

Alignment Length:	420	Identity:	142/420 - (33%)
Similarity:	215/420 - (51%)	Gaps:	82/420 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   679 EKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGEVTLVSKIDTSN 743
            |:|::    |...::.::::   ..:::::....|.|.|.|..||.:|.|:||:|.||.||..|:
Human    35 EEEIN----PQTEEVSIKEI---AITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSD 92

  Fly   744 --HLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLM 806
              .|||||.|:||.:..|::| ..|.|||||.|.::.::|||:|:||.:..||.::|::.||||.
Human    93 ARQLYAMKVLKKATLKVRDRV-RTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLF 156

  Fly   807 SLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWT 871
            :.|.|..:|.||..:||:||:..|:|.:|.:|.|:||:||:|||:|.:||||||||||.
Human   157 TRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLS------ 215

  Fly   872 HNSKYYQENGNHSRQDSMEPWEEYSENGPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPEVLERS 936
                  :|:.:|.::                               |:|..||..|:||||:.|.
Human   216 ------KESIDHEKK-------------------------------AYSFCGTVEYMAPEVVNRR 243

  Fly   937 GYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREATDLIRRLC- 1000
            |:||..|:||.||:::|||.|..||......||...::..:..:   ||. ||.||..|:|.|.
Human   244 GHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGM---PQF-LSPEAQSLLRMLFK 304

  Fly  1001 --------------ASADKRLGKSVDEVKSHDFFKGIDFADM--RKQKAPYIPEIKHPTDTSNFD 1049
                          |..|     .|:|:|.|.||..||:..:  |:...|:.|....|.||..||
Human   305 RNPANRLVNPFLIGAGPD-----GVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFD 364

  Fly  1050 PVDPEKLRSNDSTMSSGDDVDQNDRTFHGF 1079
            |....|...:...:....:..|   .|.||
Human   365 PEFTAKTPKDSPGIPPSANAHQ---LFRGF 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	135/379 (36%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	118/317 (37%)
RPS6KA3	XP_011543857.1	S_TKc	68..333	CDD:214567	118/317 (37%)
		STKc_RSK_N	72..394	CDD:270734	134/376 (36%)
		STKc_RSK2_C	408..737	CDD:271078
		Pkinase	428..685	CDD:278497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910