Protein Alignment wts and lats2

DIOPT Version :9

• Sequence 1: NP_733403.1
• Gene: wts / 43651
• FlyBaseID: FBgn0011739
• Length: 1105
• Species: Drosophila melanogaster
• Sequence 2: NP_001116779.1
• Gene: lats2 / 567674
• ZFINID: ZDB-GENE-050119-6
• Length: 1140
• Species: Danio rerio
• Alignment Length: 1216
• Identity: 456/1216 - (37%)
• Similarity: 585/1216 - (48%)
• Gaps: 346/1216 - (28%)

  Fly    14 DKYTAEALESIKQ---DLTRFEVQNNHRNNQNYTPLRYTATNGRNDALTPDYHHAKQPMEP---- 71
            |.:|.:.:..|||   ..:......:||          ||..|..|...|.||....|:..
Zfish   147 DPHTEQIVRVIKQTSPGKSGMPSLMDHR----------TAMEGSGDGALPPYHQMGAPLYEGASY 201

  Fly    72 --------------------PPSASPAPDVVIPPPPAIVGQP---GAGSISV------------- 100
                                ||.|:|:..|.:..|   :|:|   ||.|.::
Zfish   202 GAEGEMARAYMGGPPVMNYMPPPANPSQGVTMGNP---MGRPASMGAYSTNMAPQNNTGNPMYTP 263

  Fly   101 ---------SGVGVGVVGVANGRVPKMMTALMPNKLIRKPSIERDTASSHY-LRCSPALDSGAGS 155
                     ||:...::|.:....|..:.:        :||   ....:|| .|.....:|..|.
Zfish   264 GPAQQKGYPSGIDQAMMGYSVSGPPMQIQS--------QPS---GGPGAHYDYRSHMMENSSYGV 317

  Fly   156 SRSDSPHSHHTHQPSSRTVGNPG------GNGGFSPSPSGFSEVAPPAPPPRNPTACSAATPPPP 214
            .||.|..:......:...|..||      ..||::|     :...||...||..:
Zfish   318 KRSASFQNKMPQLTTENYVNMPGKAAMGQNAGGYAP-----NLYLPPHSHPRQAS---------- 367

  Fly   215 VPPTSQAYVKRRSPALNNRPPAIAPPTQRGNSPVITQNGLKNPQQQLTQQLKSLNL------YPG 273
             |.:.|.::.:       |||.:||....|....:       ||..||....||||      :||
Zfish   368 -PTSHQVHMMQ-------RPPGVAPGAMGGEFSDV-------PQGLLTPSRASLNLDLYEHHWPG 417

  Fly   274 --GGSGAVVEPPPPYLIQGGAGGAAPPPPPPSYTASMQSRQSPTQSQQSDYRKSPSSGIYS--AT 334
              |..|.    ||....||...|..   ..||.|.|..:.|..|..|    ...|::.:..  .:
Zfish   418 AQGPEGT----PPARQPQGPFRGEV---RVPSRTNSFNNHQKVTVRQ----TLPPTASVAGKPES 471

  Fly   335 SAGSPSPIT-VSLPPAPLAKPQPRVYQARSQQPIIMQSVKSTQVQKPVLQTAVAPQSPSSASASN 398
            |.|.|:.|| |:.||                   |...|||.:|.:|..:|||.|..|...||.:
Zfish   472 SLGPPNTITAVTSPP-------------------IQPPVKSIRVMRPEPKTAVGPCHPGWLSAQS 517

  Fly   399 SPVHVLAAPPSYPQKSAAVVQQQQQAAAAAHQQQHQHQQSKPPTPTTPPLVGLNSKPNCLEPPSY 463
            ...          |.|...:..:....    :...:|:...||.|.|..:.|...:|..|||.:.
Zfish   518 PEA----------QDSLGYIPDENFTL----EPSQEHRCPPPPYPKTLLVSGSGPEPASLEPVAM 568

  Fly   464 AKSMQAKAATVVQQQQQQQQQQQQVQQQQVQQQQQQQQQQLQALRVLQAQAQRERDQRERDQRER 528
            : .:|..:||           .:.:|...|.:|::                            ..
Zfish   569 S-GLQDVSAT-----------GRTIQSSSVGKQEE----------------------------PI 593

  Fly   529 ERDQQKLANGNPGRQMLPPPPYQSNNNNNSEIKPPSCNNNNIQISNSNLATTPPIPPAKYNNNSS 593
            .:|:.|:..|
Zfish   594 FKDKVKMGKG------------------------------------------------------- 603

  Fly   594 NTGANSSGGSNGSTGTTASSSTSCKKIKHASPIPERKKISKEKEEERKEFRIRQYSPQAFKFFME 658
                              ..:...||....||:|.||   ..::||::|.||:.|||.||||:||
Zfish   604 ------------------EKAVKDKKQIQTSPVPVRK---NARDEEKRESRIKSYSPFAFKFYME 647

  Fly   659 QHIENVIKSYRQRTYRKNQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLK 723
            ||:|||:|:|:|:..|:.|||:||.|.||.:..|.:|||||.||||||.||:|||||||||||:|
Zfish   648 QHVENVMKTYQQKLNRRMQLEQEMSKAGLSEAEQEQMRKMLYQKESNYNRLRRAKMDKSMFVKIK 712

  Fly   724 PIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQ 788
            .:|:||||||.|..|:|| ..|||||||||.|||.|||||||||||||||||||.|||:||||||
Zfish   713 TLGIGAFGEVCLTRKVDT-GALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVRLYYSFQ 776

  Fly   789 DKDNLYFVMDYIPGGDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDR 853
            |:||||||||||||||:|||||::|:|.|.|||||:||:|.|::||||||||||||||||||||.
Zfish   777 DRDNLYFVMDYIPGGDMMSLLIRMGVFPEVLARFYVAELTLAIESVHKMGFIHRDIKPDNILIDL 841

  Fly   854 DGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQDSMEP---WEEYS--ENGPKPTVLERRRMRDH 913
            |||||||||||||||||||||||||: |||.|||||||   |::.|  ..|.:...||:|..|.|
Zfish   842 DGHIKLTDFGLCTGFRWTHNSKYYQK-GNHIRQDSMEPSDSWDDVSNCRCGDRLMTLEQRATRQH 905

  Fly   914 QRVLAHSLVGTPNYIAPEVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEK 978
            ||.|||||||||||||||||.|.|||||||:|||||||:|||||||||||.:|.|.|.||||||.
Zfish   906 QRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTEAQLKVINWEN 970

  Fly   979 TLHIPPQAELSREATDLIRRLCASADKRL-GKSVDEVKSHDFFKGIDF-ADMRKQKAPYIPEIKH 1041
            ||.:|||.:||.||.|:|.:||.||::|| |....|:|:|.||..:|| :::|.|.|||.|:|.|
Zfish   971 TLQVPPQVKLSPEAVDIIGQLCCSAEERLGGNGAGEIKAHPFFSEVDFSSNLRTQPAPYRPKIAH 1035

  Fly  1042 PTDTSNFDPVDPEKLRSNDSTMSSGDDVDQNDRTF------------HGFFEFTFRRFFDDK--- 1091
            |.||||||||:.|  ....:...|||    :.||:            |.|:||||||||||.
Zfish  1036 PMDTSNFDPVEEE--GGPGAWSDSGD----STRTWDTLCSPHGKHPEHAFYEFTFRRFFDDNGCP 1094

  Fly  1092 ----QP-----------------PDMTDDQA-----------PVYV 1105
                :|                 |::.:::|           ||||
Zfish  1095 FRYPKPLEATQSLSSSDGAGSLKPELEEEEAHEEEEQGEGCEPVYV 1140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	254/379 (67%)
		S_TKc	719..1020	CDD:214567	225/306 (74%)
lats2	NP_001116779.1	UBA_LATS2	105..145	CDD:270581
		Med15	175..>635	CDD:255446	129/663 (19%)
		PKc_like	706..1088	CDD:304357	262/389 (67%)
		S_TKc	708..1013	CDD:214567	225/306 (74%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	458	1.000	Domainoid score	I472
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	662	1.000	Inparanoid score	I736
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	1	1.000	-	-		FOG0000273
OrthoInspector	1	1.000	-	-		otm26194
orthoMCL	1	0.900	-	-		OOG6_105652
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2473
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.970