DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wts and PRKG1

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_006249.1	Gene:	PRKG1 / 5592	HGNCID:	9414	Length:	686	Species:	Homo sapiens

Alignment Length:	726	Identity:	171/726 - (23%)
Similarity:	279/726 - (38%)	Gaps:	207/726 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   474 VVQQQQQQQQQQQQVQQQQVQQQQQQQQQQLQALRVLQAQAQRERDQRERDQRERER-DQQKLAN 537
            ::|:.|.:..:.:.|.:...||.|:|....||.         ..|.:|:....|... |.|.|::
Human    38 LIQKLQNELDKYRSVIRPATQQAQKQSASTLQG---------EPRTKRQAISAEPTAFDIQDLSH 93

  Fly   538 GNPGRQMLPPPPYQSNNNNNSEIKPPSCNNN---NIQISNSNLATTPPIPPAKYNNNSSNTGANS 599
                   :..|.|..:..:...||....:|:   |:::|... .....:.|.:|..:|.......
Human    94 -------VTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQ-EIVDCMYPVEYGKDSCIIKEGD 150

  Fly   600 SGG-----SNGSTGTTASSSTSCKK---------------------------------------- 619
            .|.     .:|....|......|..
Human   151 VGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTI 215

  Fly   620 ------IKHA------------SPIPER--KKISKEKEE---ERKEFRIRQYSPQAFKFFMEQHI 661
                  |||.            ..:||.  .|::...||   |..|:.|||.:.....|.:.:..
Human   216 MMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGT 280

  Fly   662 ENVIKSYRQ-------RTYRKNQL--EKEM---------------------------HKVGLPDQ 690
            .||.:....       ||..|...  ||.:                           |.:|..|.
Human   281 VNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDD 345

  Fly   691 TQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLK--------PIGVGAFGEVTLVSKIDTSNHLYA 747
            ..   .|.....|:.    .:.:.:.:.|..||        .:|||.||.|.||......:..:|
Human   346 VS---NKAYEDAEAK----AKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFA 403

  Fly   748 MKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKL 812
            ||.|:|..::...|..|:::|:.|:..|.::::|:||.:|:|...||.:|:...||:|.::|...
Human   404 MKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDR 468

  Fly   813 GIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLC--TGF---RWTH 872
            |.||:...|||.|.|..|...:|..|.|:||:||:|:::|..|:.||.|||..  .||   .||
Human   469 GSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWT- 532

  Fly   873 NSKYYQENGNHSRQDSMEPWEEYSENGPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPEVLERSG 937
                                                            ..|||.|:|||::...|
Human   533 ------------------------------------------------FCGTPEYVAPEIILNKG 549

  Fly   938 YTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREATDLIRRLCA- 1001
            :....||||:|:::||:|.|.|||....|::|...::.....:..|  .::::.|.:||::||.
Human   550 HDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFP--KKIAKNAANLIKKLCRD 612

  Fly  1002 SADKRLG---KSVDEVKSHDFFKGIDFADMRK--QKAPYIPEIKHPTDTSNFD--PVDPEKLRSN 1059
            :..:|||   ..|.:::.|.:|:|.::..:||  ...|.||.:..||||||||  |.|.::...:
Human   613 NPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPD 677

  Fly  1060 DSTMSSGDDVD 1070
            |   :||.|:|
Human   678 D---NSGWDID 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	116/375 (31%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	94/317 (30%)
PRKG1	NP_006249.1	DD_cGKI-beta	4..55	CDD:213375	3/16 (19%)
		CAP_ED	118..227	CDD:237999	12/109 (11%)
		CAP_ED	237..341	CDD:237999	19/103 (18%)
		STKc_cGK	381..641	CDD:270724	93/310 (30%)
		S_TK_X	636..>679	CDD:214529	17/45 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910