DRSC/TRiP Functional Genomics Resources

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Protein Alignment wts and PRKCE

DIOPT Version :10

Sequence 1:NP_733403.1 Gene:wts / 43651 FlyBaseID:FBgn0011739 Length:1105 Species:Drosophila melanogaster
Sequence 2:NP_005391.1 Gene:PRKCE / 5581 HGNCID:9401 Length:737 Species:Homo sapiens


Alignment Length:521 Identity:155/521 - (29%)
Similarity:251/521 - (48%) Gaps:104/521 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   590 NNSSNTGANSSGGSN--GSTGTTASSSTSC----KKIKHASPIPERKKISKEKEEERKEFRIRQY 648
            |.:.|.|.::.|.:.  ...|.|....|:.    ||:...:..|:....|...||:|.  :....
Human   287 NVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRS--KSAPT 349

  Fly   649 SPQAFKFFMEQHIENVIKSYRQRTYRKNQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIR---LK 710
            ||      .:|.|:.:..:.|:.....|:.| |......||      .::::..|:..:|   .|
Human   350 SP------CDQEIKELENNIRKALSFDNRGE-EHRAASSPD------GQLMSPGENGEVRQGQAK 401

  Fly   711 RAKMDKSMFVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEA 775
            |..:|:..|:|:  :|.|:||:| :::::...:.:||:|.|:|..:|:.:.|.....|:.|||.|
Human   402 RLGLDEFNFIKV--LGKGSFGKV-MLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALA 463

  Fly   776 DNN-WVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGF 839
            ..: ::.:||..||.||.|:|||:|:.|||||..:.:...|:|..:|||.||||.|:..:|:.|.
Human   464 RKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGV 528

  Fly   840 IHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQDSMEPWEEYSENGPKPTV 904
            |:||:|.||||:|.:||.||.|||:|                           :|...||     
Human   529 IYRDLKLDNILLDAEGHCKLADFGMC---------------------------KEGILNG----- 561

  Fly   905 LERRRMRDHQRVLAHSLVGTPNYIAPEVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLET 969
                       |...:..|||:|||||:|:...|....|:|::||::|||:.|||||.|::..:.
Human   562 -----------VTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDL 615

  Fly   970 QQKVIN-------WEKTLHIPPQAELSREATDLIRR-LCASADKRLG-----KSVDEVKSHDFFK 1021
            .:.:::       |           ||:||..:::. :..:..||||     ...|.:|.|.|||
Human   616 FESILHDDVLYPVW-----------LSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFK 669

  Fly  1022 GIDFA--DMRKQKAPYIPEIKHPTDTSNFDPVDPEKLRSNDSTMSSGDD--VDQ-NDRTFHGFFE 1081
            .||:.  :.:|.|.|:.|.||...|.:|||    :.....:..::..|:  |.| |...|.||..
Human   670 EIDWVLLEQKKIKPPFKPRIKTKRDVNNFD----QDFTREEPVLTLVDEAIVKQINQEEFKGFSY 730

  Fly  1082 F 1082
            |
Human   731 F 731

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wtsNP_733403.1 MobB_LATS1 644..718 CDD:439273 15/76 (20%)
STKc_LATS 717..1078 CDD:270749 123/379 (32%)
PRKCENP_005391.1 C2_PKC_epsilon 3..135 CDD:175981
C1_nPKC_epsilon-like_rpt1 161..224 CDD:410385
Interaction with actin. /evidence=ECO:0000250 223..228
C1_nPKC_epsilon-like_rpt2 241..295 CDD:410388 3/7 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 325..356 8/38 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 370..398 7/34 (21%)
STKc_nPKC_epsilon 412..732 CDD:270743 125/381 (33%)
Blue background indicates that the domain is not in the aligned region.

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