Protein Alignment wts and lats1

DIOPT Version :10

• Sequence 1: NP_733403.1
• Gene: wts / 43651
• FlyBaseID: FBgn0011739
• Length: 1105
• Species: Drosophila melanogaster
• Sequence 2: NP_001018346.1
• Gene: lats1 / 553164
• ZFINID: ZDB-GENE-050523-2
• Length: 1068
• Species: Danio rerio
• Alignment Length: 1216
• Identity: 478/1216 - (39%)
• Similarity: 594/1216 - (48%)
• Gaps: 368/1216 - (30%)

  Fly     3 PAGEKRGGR---PNDKYTAEALESIKQDLTRFEVQNNHRNNQNYTPLRYTATNGRNDALTPDYHH 64
            |...::.||   |.:.:...||:.|::.|               .|..:.:::..:::......|
Zfish    59 PDESRQQGRSTNPRNSHHHRALQEIRKSL---------------QPFAHDSSSSGDNSSADSSKH 108

  Fly    65 AKQPMEPP--------------------PSASPAPDVVIPPPPAIVGQPGAGSISVSGVGVGVVG 109
            ..|..||.                    |||.|....:....|..:.||
Zfish   109 TLQTQEPGFDEELMVNRINFQEAVREQIPSARPVNTAIKQAGPPQIQQP---------------- 157

  Fly   110 VANGRVPKMMTALMPNKLIRKPSIERDTASSHYLRCSPALDSGAGSSRSDSPHSHHT-------H 167
                             |:|:                   .|..||..|.:|..|..       :
Zfish   158 -----------------LLRR-------------------QSWKGSKESLAPQRHSALINDVLIY 186

  Fly   168 QPSSRTVGNPGGNGGFSPSPSGFSEVAPPAPPPRNPTACSA-------------ATPPPPVPPTS 219
            :||             ||.|.  |:::.||..|:|..:.|:             :..|||....|
Zfish   187 RPS-------------SPGPQ--SDLSRPATFPQNLASASSGQRVNAPLSRQVRSITPPPSSWDS 236

  Fly   220 QAYVKRRSPALNNRPPAIAPPTQ--RGNSPVITQNGLKNPQQQLTQQLKSLNLYPGGGSGAVVEP 282
            ....||.|..|:...|.|:|..|  ||       :|..|||   :|..:.|...|.|....:::.
Zfish   237 NPSTKRYSGNLDYLVPRISPVPQGPRG-------DGYINPQ---SQNQRGLRPVPVGRQPIIMQN 291

  Fly   283 P-------PPYLIQGGA---------GGAAPPPPPPSYTASMQSRQSPT-QSQQSDYRKSPSSGI 330
            .       ||...|.|:         .||..||||| |:....:||||| |..||....:|.:|.
Zfish   292 SNSNKFNFPPSWPQNGSMQNEYMGMNSGARQPPPPP-YSMHQTNRQSPTAQQMQSSALTAPPNGA 355

  Fly   331 YSATSAGSPSPITVSLPPAPLAKPQPRVYQAR--------------------------------- 362
            ....|...|:..:.:|....|...:|.|.||:
Zfish   356 SLPQSMLVPNRNSHNLDMYNLGVIRPPVQQAQTPPGQDTSSSWTHSVPGRSNSFTSAPNNRRQCP 420

  Fly   363 ------------SQQPIIMQSVKSTQVQKPVLQTAVAPQSPSSASASNSPVHVLAAPPSYPQKSA 415
                        :|.| |:|.|||.:||||.|.|||||..|.          .|..||
Zfish   421 NSQLSATTVTTVTQAP-ILQPVKSMRVQKPELHTAVAPAHPP----------WLQPPP------- 467

  Fly   416 AVVQQQQQAAAAAHQQQHQHQQSKPPTPTTPPLVGLNSKPNCLEPPSYAKSMQAKAATVVQQQQQ 480
                      ..|:|:        ||||..|          ..|.|||..........::||||
Zfish   468 ----------PTAYQE--------PPTPPAP----------AAEVPSYQGPPPPYPKHLLQQQQ- 503

  Fly   481 QQQQQQQVQQQQVQQQQQQQQQQLQALRVLQAQAQRERDQRERDQRERERDQQKLANGNPGRQML 545
                                                                             
Zfish   504 ----------------------------------------------------------------- 503

  Fly   546 PPPPYQSNNNNNSEIKPPSCNNNNIQISNSNLATTPPIPPAKYNNNSSNTGANSSGGSNGSTGTT 610
            |||.|.|    :..:||  |:...               .|..|.|.:::..:|.         .
Zfish   504 PPPGYDS----SPALKP--CSKEG---------------DAADNENDTDSTCSSE---------R 538

  Fly   611 ASSSTSCKKIKHASPIPERKKISKEKEEERK-EFRIRQYSPQAFKFFMEQHIENVIKSYRQRTYR 674
            |..|...||....||:|.|:   .:::|||| |.|:..|||||||||||||:||::|:::||..|
Zfish   539 AEGSEEEKKQITTSPVPVRR---HKRDEERKGESRLPMYSPQAFKFFMEQHVENILKNHQQRMRR 600

  Fly   675 KNQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGEVTLVSKI 739
            |.|||.||.:|||....|.:||.||:||||||||||||||||.||.|:|.:|:||||||.|..|:
Zfish   601 KKQLESEMQRVGLSGDAQEQMRMMLSQKESNYIRLKRAKMDKCMFEKIKTLGIGAFGEVCLARKV 665

  Fly   740 DTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGD 804
            || ..|||||||||.|||.|||||||||||||||||||.|||:||||||||||||||||||||||
Zfish   666 DT-GALYAMKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGD 729

  Fly   805 LMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFR 869
            :|||||::|||:|:||:|||||:.|||:|||||||||||||||||||||||||||||||||||||
Zfish   730 MMSLLIRMGIFQEDLAQFYIAELICAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFR 794

  Fly   870 WTHNSKYYQENGNHSRQDSME---PWEEYSEN---GPKPTVLERRRMRDHQRVLAHSLVGTPNYI 928
            |||:||||| :|:|.|||||:   .||: |.|   |.:...||||..|.|||.||||||||||||
Zfish   795 WTHDSKYYQ-SGDHVRQDSMDFSMEWED-SANCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYI 857

  Fly   929 APEVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREAT 993
            |||||.|:|||||||:||||||||||:||||||||.:|||||.|||.|:.:||||.||:||.|||
Zfish   858 APEVLLRTGYTQLCDWWSVGVILYEMVVGQPPFLATTPLETQMKVIRWQTSLHIPLQAKLSPEAT 922

  Fly   994 DLIRRLCASADKRLGKS-VDEVKSHDFFKGIDFA-DMRKQ-KAPYIPEIKHPTDTSNFDPVDPEK 1055
            |||.:||...|.|||:: .||:|:..||:.||.: |:|:| :|||||:|.|.|||||||||||:|
Zfish   923 DLILKLCRGPDDRLGRNGADEIKAQPFFRTIDLSKDLRQQHQAPYIPKITHSTDTSNFDPVDPDK 987

  Fly  1056 LRSNDSTMSSGDDVDQNDRTF-------HGFFEFTFRRFFDDKQPP 1094
            |.|.|   :.|:..|...|.|       |.|:||||||||||...|
Zfish   988 LWSED---ADGNHNDTLTRWFKNGKHPEHAFYEFTFRRFFDDSGHP 1030

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	MobB_LATS1	644..718	CDD:439273	50/73 (68%)
		STKc_LATS	717..1078	CDD:270749	263/376 (70%)
lats1	NP_001018346.1	PHA03247	<137..516	CDD:223021	119/572 (21%)
		MobB_LATS1	569..644	CDD:439273	50/74 (68%)
		Protein Kinases, catalytic domain	644..1024	CDD:473864	271/385 (70%)