DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wts and Pkc53E

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	151/519 - (29%)
Similarity:	244/519 - (47%)	Gaps:	120/519 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   626 IPERKKISKEK--------------------EEERKEFRI-------RQYSPQAFKFFMEQHIEN 663
            ||:.|..||:|                    :.|.|:.||       .:.|...|...:...|..
  Fly   219 IPDDKDQSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFMGALSFGISE 283

  Fly   664 VIKSYRQRTYR-KNQLEKEMHKVGLPDQTQ--IEMRKMLNQKESNYIR--------LKRAKMDKS 717
            :||:.....:: ..|.|.|.:.|...|..|  :::::..:||:...:|        .|:..:..:
  Fly   284 IIKNPTNGWFKLLTQDEGEYYNVPCADDEQDLLKLKQKPSQKKPMVMRSDTNTHTSSKKDMIRAT 348

  Fly   718 MFVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADN-NWVV 781
            .|..:|.:|.|:||:|.|..: ..|..|||:|.|:|..:::.:.|.....|:.:||..:. .::|
  Fly   349 DFNFIKVLGKGSFGKVLLAER-KGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLV 412

  Fly   782 KLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKP 846
            :|:..||..|.|:|||:|:.|||||..:.:.|.|:|.:|.||.||:...:..:|..|.::||:|.
  Fly   413 QLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKL 477

  Fly   847 DNILIDRDGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQDSMEPWEEYSEN--GPKPTVLERRR 909
            ||:|:|.|||:|:.|||:|                              .||  |.|.|
  Fly   478 DNVLLDADGHVKIADFGMC------------------------------KENIVGDKTT------ 506

  Fly   910 MRDHQRVLAHSLVGTPNYIAPEVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKV- 973
                     .:..|||:|||||::....|.:..|:|:.||:|||||||||||......|....:
  Fly   507 ---------KTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAIT 562

  Fly   974 ---INWEKTLHIPPQAELSREATDLIRR-LCASADKRLG---KSVDEVKSHDFFKGIDF--ADMR 1029
               :::.|:        ||:||.:..:. |....:||||   ...::|:.|.||:.||:  .:.|
  Fly   563 DHNVSYPKS--------LSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDWEKIENR 619

  Fly  1030 KQKAPYIPEIKHPTDTSNFDPVDPEKLRSNDSTMSSGDDV-----DQNDRTFHGFF----EFTF 1084
            :.:.|:.|:|||..|.||||    ::..|..:.::..|.|     ||::  |.||.    |:.|
  Fly   620 EVQPPFKPKIKHRKDVSNFD----KQFTSEKTDLTPTDKVFMMNLDQSE--FVGFSYMNPEYVF 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	122/378 (32%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	101/311 (32%)
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992	18/87 (21%)
		STKc_cPKC	353..672	CDD:270739	123/378 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010