DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wts and aPKC

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_001260984.1	Gene:	aPKC / 47594	FlyBaseID:	FBgn0261854	Length:	958	Species:	Drosophila melanogaster

Alignment Length:	1145	Identity:	237/1145 - (20%)
Similarity:	388/1145 - (33%)	Gaps:	386/1145 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 VANGRVPKMMT--ALMPNKLIRKPSIERDTASSHYLRCSPALDSGAGSSRSDSPHSHHTHQPSSR 172
            |..||.|:.:|  |.:|..::::...|...       |.|          ....|.....|..|:
  Fly    11 VDRGRSPRRLTQCAPLPVNIVQQEEEEEQP-------CLP----------QQQQHQQTQQQQQSQ 58

  Fly   173 TV-----GNPGGNGGFSPSPSGFSEVAPPAPPPRNPTACSAATPPPPVPPTS---QAYVKRRSPA 229
            |.     .|..|:|....||:..|..:.|.|    .:.|.:.|||||...||   ..:..:..||
  Fly    59 TCPSTPSANQQGSGNLCYSPTCRSRCSSPCP----GSPCGSITPPPPPMLTSSQQHLHSNKNCPA 119

  Fly   230 LNNRPPAIAPPTQRGNSPVITQNGLKNPQQQ-----------------LTQQLKSLN-------- 269
            .......:....:|.     :.:.|.:||.:                 :...::|.|
  Fly   120 AQQLMTHLDYAARRQ-----SLDQLDSPQSKYFDIQANQLSDIMCRGAVVSSIQSANNTLTRGVS 179

  Fly   270 -------------------LYPGGGSGAVVEPPPPYLIQGGAG---------------------G 294
                               .:.|...|::      ..:|||.|                     |
  Fly   180 MHSRSGSAHGSHHGSHHSHSHHGSAHGSL------GCLQGGVGVGVGTGSTGSIGMMSAGHIDTG 238

  Fly   295 AAPPPPPPSYTAS-MQSRQSPTQSQQSDYRKSPSSGIYSATSAGSPSP-----------ITVSLP 347
            ....|.|..||.. ||:..|.|....|..|...:..:.....:||.|.           :.:..|
  Fly   239 DYDVPHPHPYTHHYMQTTASVTPPHTSLSRPGSAGAVCQGHDSGSDSSQGCGGSIMGGMLVMGHP 303

  Fly   348 ------------PAPLAKPQPRVYQARSQQ--------------PIIMQSVKSTQVQKP--VLQT 384
                        ...|.:...|.:...:..              |..|.|. |..|..|  ::..
  Fly   304 GHMGSLGHHSAGSGSLGRCSSRCHNTNTTTTDDSGGGSSGGGGVPGTMSSA-SMAVGMPGMLMDY 367

  Fly   385 AVAPQSPSSASASNSPVHVLAAPPSYPQKSAAVVQQQQQAAAAAHQQQHQ---HQQSKP---PTP 443
            ..:..|.|:.|..|.......|..|...:| :|:..........|||.|.   |.:..|   |.|
  Fly   368 HHSHHSGSAGSGLNGCGGGSIAGGSIGGRS-SVLGTIHNGHGHHHQQYHHECIHYERLPIPVPIP 431

  Fly   444 TTPPLVGLNSKPNCLEPPSYAKSMQAKAATVVQQQQQQQQQQQQVQQQQVQQQQQQQQQQLQALR 508
            |.|..|..:|                                     ||:.|.|.|.:::::
  Fly   432 TVPMGVAPSS-------------------------------------QQMSQHQLQSEEEIE--- 456

  Fly   509 VLQAQAQRERDQRERDQRERERDQQKLANGNPGRQMLPPPPYQSNNNNNSEIKPPSCNNNNIQI- 572
                                                   |.|.:...|..:....||:..:..|
  Fly   457 ---------------------------------------PAYATVFPNVPQAPGLSCDGEDRSIY 482

  Fly   573 ------------SNSNLATTPPIPPAKYNNNSSNTGANSSGGSNGSTGTTASS-----STSCKKI 620
                        .|.::     ....::|..:............|..|.....     ...|.|:
  Fly   483 RRGARRWRKLYRVNGHI-----FQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKL 542

  Fly   621 --KHASPIPERKKISKEKEEERKE----------FRIRQYSPQAFKFFMEQHI------ENVIKS 667
              ||.:..||  .:.||:.||..:          :.......:|.:.....||      |:.::.
  Fly   543 VQKHCTDQPE--PLVKERAEESSDPIPVPLPPLPYEAMSGGAEACETHDHAHIVAPPPPEDPLEP 605

  Fly   668 YRQRTYRKNQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGE 732
            ..||.|..|..|                                         .::.||.|::.:
  Fly   606 GTQRQYSLNDFE-----------------------------------------LIRVIGRGSYAK 629

  Fly   733 VTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNN-WVVKLYYSFQDKDNLYFV 796
            |.:| ::..:..:||||.::||.|.....:..|:.|:.:...|.|: ::|.|:..||....|:||
  Fly   630 VLMV-ELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFV 693

  Fly   797 MDYIPGGDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTD 861
            ::::.|||||..:.:.....||.||||.||::.|::.:|:.|.|:||:|.||:|:|.:|||||||
  Fly   694 IEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTD 758

  Fly   862 FGLCTGFRWTHNSKYYQENGNHSRQDSMEPWEEYSENGPKPTVLERRRMRDHQRVLAHSLVGTPN 926
            :|:|                    ::.:.|.:..|                       :..||||
  Fly   759 YGMC--------------------KEGIRPGDTTS-----------------------TFCGTPN 780

  Fly   927 YIAPEVLERSGYTQLCDYWSVGVILYEMLVGQPPF-LANSPLETQQKVINW------EKTLHIPP 984
            |||||:|....|....|:|::||:|||||.|:.|| ||.:.....|...::      |||:.||
  Fly   781 YIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIP- 844

  Fly   985 QAELSREATDLIRR-LCASADKRLG----KSVDEVKSHDFFKGIDFADMRKQKA--PYIPEIKHP 1042
             ..||..|..:::. |..:...|||    .:..::.||.|||.:|:..:.:::.  |:.|.:...
  Fly   845 -RSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSD 908

  Fly  1043 TDTSNFDPV---DPEKLRSNDSTMSSGDDVDQNDRTFHGF 1079
            .|.:||.|.   :..:|..:|..:.  |::||::  |.||
  Fly   909 RDLANFPPEFTGEAVQLTPDDDHVI--DNIDQSE--FEGF 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	114/378 (30%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	98/313 (31%)
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	7/56 (13%)
		S_TKc	616..884	CDD:214567	99/354 (28%)
		STKc_aPKC	620..947	CDD:270740	116/375 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24356
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100