DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wts and gwl

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_524860.2	Gene:	gwl / 45969	FlyBaseID:	FBgn0260399	Length:	846	Species:	Drosophila melanogaster

Alignment Length:	485	Identity:	133/485 - (27%)
Similarity:	205/485 - (42%)	Gaps:	101/485 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   661 IENVIKSYRQRTYRKNQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLKPI 725
            :||...:.:...:...:..|:.|.: :..:..::...:|..|..|:.:..:....|. ||.:|||
  Fly     1 MENADATSQSDVHIDYKTPKKTHSL-IDSEQLLDKINILTTKPENHSQNAKLPTIKD-FVIIKPI 63

  Fly   726 GVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDK 790
            ..||||:|.|..|.:.|..|:|:|.:||::::.:|.|:.|..||:.||.:.:.:.|.|:||.|..
  Fly    64 SRGAFGKVFLGYKNNDSKRLFAIKVMRKSEMINKNMVSQVITERNALALSRSQFCVSLFYSLQSL 128

  Fly   791 DNLYFVMDYIPGGDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDG 855
            ..:|.||:|:.||||.|||...|.|:|..||||:||:..|:..:|:.|.:||||||||:|:...|
  Fly   129 SYVYLVMEYMVGGDLKSLLAMFGYFDEPTARFYVAEMVMALQYLHQHGIVHRDIKPDNMLLSSSG 193

  Fly   856 HIKLTDFGLCTGFRWTHNSKYYQENGNHSRQDSMEPWEEYSE--------NGPKPTVL------- 905
            |:|||||||         ||.      ..|:|.     |.|:        |...|..|
  Fly   194 HVKLTDFGL---------SKI------DMRRDL-----EISDLINCSPNLNARTPGQLLSLTSHL 238

  Fly   906 ---ERRRMRDH----------------------QRVLAHSLVGTPNYIAPEVLERSGYTQLCDYW 945
               ..:::.|.                      |.:..|||:       .|:.:..|.|.|.|..
  Fly   239 SFGSEKKLNDFGSVSSGQNNGMGSVATGTSHLLQAINKHSLI-------MELSDSEGDTSLNDAE 296

  Fly   946 SVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREATDLIRRLCASADKRLGKS 1010
            ...   ...:.|..||.:   .|...:.|....|.::.||    ..::......|.|||  |.|.
  Fly   297 KTS---DSKISGVSPFFS---AEEANESITHTCTTNVNPQ----DSSSSCSFHTCNSAD--LSKC 349

  Fly  1011 VDEVKSHDFFKGIDFADMRKQKAPYIPEIKHPTDTSNFDPVDPEKLRSNDST---MSSGDDVDQN 1072
            ...::|.|   |....:.       ||..:......:..|....||...||:   .:.|..:.:.
  Fly   350 SPPLESKD---GAAAGNA-------IPSKRRVEFVLDAAPCQGCKLAEQDSSNMATNDGKHLPKI 404

  Fly  1073 DRTFHGFFEFTF--RRFFDD-----KQPPD 1095
            |......|||:.  ||..|:     |.|.|
  Fly   405 DNAIEASFEFSMVRRRSVDERNRISKGPED 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	116/403 (29%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	106/340 (31%)
gwl	NP_524860.2	STKc_MASTL	52..>255	CDD:270761	82/223 (37%)
		S_TKc	57..>205	CDD:214567	72/156 (46%)
		PKc_like	<655..835	CDD:304357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458918
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24356
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030