DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wts and for

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_477487.1	Gene:	for / 44817	FlyBaseID:	FBgn0000721	Length:	1088	Species:	Drosophila melanogaster

Alignment Length:	1255	Identity:	273/1255 - (21%)
Similarity:	419/1255 - (33%)	Gaps:	520/1255 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 AGSSRSDSPHSHHTHQPSSRTVGNPGGNGGFSPSPSGFSEVAPPAPPPRNPTACSAATP-PPPVP 216
            |.:|.|::||       ||.||.                  |||.|...:......||| |||..
  Fly    16 AQNSNSNAPH-------SSTTVD------------------APPRPADVDVATVPVATPAPPPQQ 55

  Fly   217 PTSQAY---VKRRSPALNNR-----------------PPAIAPPTQRGNSPVITQNGLKNPQQQL 261
            |.|..:   .::..||:.:|                 ||.|....:    ||       ..|:|:
  Fly    56 PVSNLFYADYQKLQPAIIDRDWERDRDTDTDTRSEAKPPDIVEHIE----PV-------EEQRQI 109

  Fly   262 TQQLKSLNLYPGGGSGAVVEPPPPYLIQGGAGGAAPPPPPPSYTASMQSRQSPTQSQQSDYRKSP 326
            ..|::|               |....||     ..|.||.||....:|.|          ||:..
  Fly   110 HTQIQS---------------PAEIQIQ-----IPPTPPAPSIQIQIQQR----------YRRHS 144

  Fly   327 SSGIYSATSAGSPSPITVSLPPAPLAKPQPRVYQARSQQPIIMQSVKSTQVQKPVLQTAVAPQSP 391
            |:...:..:..:.|.||.:|..|...:.:|   .|..|.|..:..|.......   .|...|...
  Fly   145 SAEDRNLNTRRNDSNITEALRKAASMQQEP---NANYQFPTDLGLVSIVNNNN---NTNTHPSGS 203

  Fly   392 SSASASNSPVH------VLAAPPSYPQKSAAVVQQQQQAAAAAHQQQHQHQQS------KPPTPT 444
            :|.|.:||.::      ::..|                  ||......:|..|      .|||.:
  Fly   204 NSGSNNNSNINNNLVGGIVTLP------------------AAGGLIGLEHTASGLRLIPAPPTHS 250

  Fly   445 ---TPPLV-GLNSKPNCLEPPSYAKSMQAKAATVVQQQQ-QQQQQQQQVQQQQVQQQ-------- 496
               |..|: |        .|||.|:.:.....:::.||: |.||:.||:||.|.|.|
  Fly   251 DVLTHTLIYG--------TPPSGAQQLNQDPRSLLHQQELQLQQRYQQLQQLQAQTQGLYTSQGS 307

  Fly   497 --------------------------QQQQ------QQQLQALRV-------------------- 509
                                      |.|.      |||:|:||:
  Fly   308 PVLYHQPSPGSSQPVAIPGATCHSPTQLQPPNTLNLQQQMQSLRISGCTPSGTGGSATPSPVGLV 372

  Fly   510 ---------LQAQAQRER-----DQRERDQRERERDQQKLANGNPGRQMLPPPPYQSNNNNNSEI 560
                     :.|..|.||     ..:|...:|.:|                  ..|..:|..:|:
  Fly   373 DPNFIVSNYVAASPQEERFIQIIQAKELKIQEMQR------------------ALQFKDNEIAEL 419

  Fly   561 KPPSCNNNNIQISNSNLATTPPIPPAKYNN--------NSSNTGANSSGGSNGSTGTTAS----- 612
            |             |:|.....:.|....:        .:|.:||..||||...|.|.|:
  Fly   420 K-------------SHLDKFQSVFPFSRGSAAGCAGTGGASGSGAGGSGGSGPGTATGATRKSGQ 471

  Fly   613 --------------SSTSCKKIKHAS--------------------------------------- 624
                          .|.|...::|.|
  Fly   472 NFQRQRALGISAEPQSESSLLLEHVSFPKYDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCM 536

  Fly   625 -PI--PERKKISKEKEE------------------------------------------------ 638
             |:  |.:..|.||.:.
  Fly   537 YPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAI 601

  Fly   639 --------ERKEFR--------IRQ--YSP-----QAFKFFMEQ---HIENVIKS--YRQRTYRK 675
                    ||:.|:        |||  ||.     ..||...|.   .|.:|::.  |::..|..
  Fly   602 TECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIV 666

  Fly   676 NQ---------LEKEMHKVGLPDQ-TQIEM----------------------------------- 695
            .|         :.|...:|.:..| ||.|.
  Fly   667 RQGARGDTFFIISKGKVRVTIKQQDTQEEKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVS 731

  Fly   696 -----RKMLNQKESNYIRLKRAKMDKSMFVKLK-----------------PIGVGAFGEVTLVSK 738
                 |:..||..||...:|....|:....:.|                 .:|||.||.|.||..
  Fly   732 CLVIDRETFNQLISNLDEIKHRYDDEGAMERRKINEEFRDINLTDLRVIATLGVGGFGRVELVQT 796

  Fly   739 IDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGG 803
            ...|:..:|:|.::|:.:::..|..|:.:|::|:.||:..::|||:.:|:||..||.:|:...||
  Fly   797 NGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGG 861

  Fly   804 DLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFG----L 864
            :|.::|...|.|::...|||.|.|..|.|.:|....|:||:||:|:|::..|::||.|||    |
  Fly   862 ELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKL 926

  Fly   865 CTGFR-WTHNSKYYQENGNHSRQDSMEPWEEYSENGPKPTVLERRRMRDHQRVLAHSLVGTPNYI 928
            .||.: ||                                                 ..|||.|:
  Fly   927 QTGRKTWT-------------------------------------------------FCGTPEYV 942

  Fly   929 APEVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREAT 993
            ||||:...|:....||||:||:::|:|.|.|||..:.|:.|...::.....:..|  ..::|.|:
  Fly   943 APEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFP--RNITRNAS 1005

  Fly   994 DLIRRLCA-SADKRLG---KSVDEVKSHDFFKGIDFADMRK--QKAPYIPEIKHPTDTSNFD--P 1050
            :||::||. :..:|||   ..:.|::.|.:|.|..:..::.  .:.|..|.:|...||:|||  |
  Fly  1006 NLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYP 1070

  Fly  1051 VDPEKLRSNDSTMSSGDDVD 1070
            .|||....:|.|   |.|.|
  Fly  1071 PDPEGPPPDDVT---GWDKD 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	114/384 (30%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	95/326 (29%)
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374	12/77 (16%)
		Crp	518..>627	CDD:223736	10/108 (9%)
		CAP_ED	520..629	CDD:237999	11/108 (10%)
		Crp	632..>753	CDD:223736	20/120 (17%)
		CAP_ED	638..754	CDD:237999	20/115 (17%)
		S_TKc	778..1036	CDD:214567	94/308 (31%)
		STKc_cGK	783..1043	CDD:270724	96/310 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910