DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wts and Mast4

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	XP_017171016.1	Gene:	Mast4 / 328329	MGIID:	1918885	Length:	2658	Species:	Mus musculus

Alignment Length:	1074	Identity:	272/1074 - (25%)
Similarity:	413/1074 - (38%)	Gaps:	262/1074 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 MPNKLIRKPSIERDTASSHYLR---CSPALDSGAGSSRSDSPHSHHTHQPSSRTVGNPGGNGGFS 184
            |..|:...|.......|.|..|   .|.|..|..|:|.::|       ...|.|:...|
Mouse     1 MGEKVSEAPEPVPRGCSGHGARTLVSSAAAVSSEGASSAES-------SSGSETLSEEG------ 52

  Fly   185 PSPSGFS-EVAPPAPP-----PRNPTACSAA------------TPPP-----PVPPTSQAYVKRR 226
             .||.|| ...||.||     .|.|.|.:.|            .|.|     |||..|.|..:.:
Mouse    53 -EPSRFSCRSQPPRPPGGALGTRLPAAWAPARVALERGVPTLPLPHPGGAVLPVPQVSSASQEEQ 116

  Fly   227 SPALNN--RPPAIAPPTQRGNSPVIT---QNGLKNPQQQLTQQLKSLNLYPGGG--SGAVVEPPP 284
            ...|::  .||.:  |.::.::|.:.   ...||. ::||::..|.|.....||  :|..:.|.|
Mouse   117 DEELDHILSPPPM--PFRKCSNPDVACGLGKSLKY-KRQLSEDGKQLRRGSLGGALTGRYLLPNP 178

  Fly   285 PYLIQGGAGGAAPPPPPPSYTASMQSRQSPTQSQQSDYRKSPSSGIYSATSAGSPSPITVSLPPA 349
            .      ||.|.|.....|....|:|:                     |....:|| :|.||...
Mouse   179 V------AGQAWPASAETSNLVRMRSQ---------------------ALGQSAPS-LTASLEGQ 215

  Fly   350 PLAKPQPRVYQARSQQPIIMQSVKSTQV---------------------------------QKPV 381
            |   |:.....||.:|.::..:....::                                 |.|.
Mouse   216 P---PKSHFNSARHRQRLVDPAASKKELSLPRRGSLVDSQKWNCLVKRCRTSNRKSLIGNGQSPA 277

  Fly   382 LQTAVAPQSPSSASASNSP------------VHVLAAP------------PSYPQKSAAVVQQQQ 422
            |.   .|.||.||.|.|||            .|...|.            .|.|...........
Mouse   278 LP---RPHSPLSAHAGNSPQDSPRNFSPSASAHFSFARRNDRTDGRRWSLASLPSSGYGTNTPSS 339

  Fly   423 QAAAAAHQQQHQHQQSKPPTP-----------TTPPLVGLNSKPNCLEPPSYAKSMQAKAATVVQ 476
            ..:::...|:..||....|||           ||..:...|   .|...|     |:.::.::..
Mouse   340 TVSSSCSSQEKLHQLPYQPTPDELHFLSKHFCTTESIATEN---RCRNTP-----MRPRSRSLSP 396

  Fly   477 QQQQQQQQQQQVQQQQVQQQQQQQQQQLQALRVLQAQAQRERDQRERDQRERERDQQKLANGNPG 541
            .:.......:.:....|.::           |..:|.||.|           ||.::.:.:.:|.
Mouse   397 GRSPACCDHEIIMMNHVYKE-----------RFPKATAQME-----------ERLKEIITSYSPD 439

  Fly   542 RQMLPPPPYQSNNNNNSEIK-PPSCNNNNIQISNSNLATTPPIPPAKYNNNSSNTGANSSGGSNG 605
             .:||......:..::..|: ...|    :..|:..|.|:......::..:.....|:    ...
Mouse   440 -HVLPLADGVLSFTHHQIIELARDC----LDKSHQGLITSRYFFELQHKLDKLLQEAH----DRS 495

  Fly   606 STGTTASSSTSCKKIKHASPIPERKKISKEKEEERKEFRIRQYSPQAFKFFME---------QHI 661
            .:|..|......:||......|.|.            ....::.|:.|.:.:|         |.|
Mouse   496 ESGELAFIKQLVRKILIVIARPARL------------LECLEFDPEEFYYLLEAAEGHAKEGQGI 548

  Fly   662 ENVIKSY--RQRTYRKNQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLK-RAKMDKSMFVKLK 723
            :..|..|  .|....|:.|| ||.::|..|....|..:|.....|:...|: |.|..:|.|..:|
Mouse   549 KTDIPRYIISQLGLNKDPLE-EMAQLGNYDSRTAETPEMDESVSSSNTSLRLRRKPRESDFETIK 612

  Fly   724 PIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQ 788
            .|..||:|.|..| :...|...:|||.:.|.:::.|||:.....|||||..|:|.:||.:|.||:
Mouse   613 LISNGAYGAVYFV-RHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFE 676

  Fly   789 DKDNLYFVMDYIPGGDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDR 853
            .:.:|..||:|:.|||..:|:..:|....::||.|.||...|::.:|..|.:|||:||||:|:..
Mouse   677 TRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTS 741

  Fly   854 DGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQDSMEPWEEYSENGPKPTVLERRRMRDHQRVLA 918
            .||||||||||......:..:..|:   .|..:|:.|                         .|.
Mouse   742 MGHIKLTDFGLSKVGLMSMTTNLYE---GHIEKDARE-------------------------FLD 778

  Fly   919 HSLVGTPNYIAPEVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKV----INWEKT 979
            ..:.|||.||||||:.|.||.:..|:|::|:||||.|||..||..::|.|...:|    |||.:.
Mouse   779 KQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEK 843

  Fly   980 LHIPPQAELSREATDLIRRLCASAD-KRLGK-SVDEVKSHDFFKGIDFADMRKQKAPYIPEIKHP 1042
            ...||.     :|.:||..|..... :|||. ...|||.|.||:.:|:..:.:|||.:||:::..
Mouse   844 DEAPPP-----DAQELITLLLRQNPLERLGTGGAYEVKQHRFFRSLDWNSLLRQKAEFIPQLESE 903

  Fly  1043 TDTSNFDPVDPEKLRSNDSTMSSGDDVDQNDRTF 1076
            .|||.|| ...||...    |.:.::.|.||..|
Mouse   904 DDTSYFD-TRSEKYHH----METEEEDDTNDEDF 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	132/366 (36%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	111/306 (36%)
Mast4	XP_017171016.1	DUF1908	293..569	CDD:370192	51/327 (16%)
		STKc_MAST	607..886	CDD:270760	113/312 (36%)
		PDZ_signaling	1184..1262	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910