DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wts and rock2a

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_777288.1	Gene:	rock2a / 317747	ZFINID:	ZDB-GENE-030115-3	Length:	1375	Species:	Danio rerio

Alignment Length:	479	Identity:	170/479 - (35%)
Similarity:	244/479 - (50%)	Gaps:	75/479 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   638 EERKEFRIRQYSPQAFKFFMEQHIENVIKSYRQRTYRK------NQLEKEMHKVGLPDQTQIEMR 696
            |.|.|.|:||             :|.:||..|.....:      |.|..::....|.....||
Zfish     6 ERRMENRLRQ-------------LEAMIKDPRSAINLESLLDSMNALVLDLDFPALRKNKNIE-- 55

  Fly   697 KMLNQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQ 761
            ..||:.|.....::..:|....|.::|.||.||||||.|| :...|..:||||.|.|.:::||:.
Zfish    56 NFLNRYEKVMNHIRELQMRPEDFDRVKVIGRGAFGEVQLV-RHKASQKVYAMKVLSKFEMIKRSD 119

  Fly   762 VAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLGIFEEELARFYIAE 826
            .|....||||:|.||:.|||:|..:|||..:||.||:|:|||||::|.....: .|:.|:||.||
Zfish   120 SAFFWEERDIMAFADSPWVVQLCCAFQDDRSLYMVMEYMPGGDLVNLTSTYDV-PEKWAKFYTAE 183

  Fly   827 VTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQDSMEP 891
            |..|:|::|.|||||||:||||:|:||.||:||.|||.|
Zfish   184 VVLALDAIHSMGFIHRDVKPDNMLLDRYGHLKLADFGTC-------------------------- 222

  Fly   892 WEEYSENGPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPEVLERSG----YTQLCDYWSVGVILY 952
                            .:|.....|...:.||||:||:||||:..|    |.:.||:|||||.:|
Zfish   223 ----------------MKMDGTGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFIY 271

  Fly   953 EMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREATDLIRRLCASADKRLGKS-VDEVKS 1016
            |||||..||.|:|.:.|..|:::.:.:|:.|...|:|:|..::|.......:.|||:| |:|:|.
Zfish   272 EMLVGDTPFYADSLVGTYSKIMDHKNSLNFPDDVEISQEGKNIICAFLTDREVRLGRSGVEEIKR 336

  Fly  1017 HDFFKGID--FADMRKQKAPYIPEIKHPTDTSNFDPVDPEKLRSNDSTMSSGDDVDQNDRTFHGF 1079
            |.||:...  |:.:|:..||.:||:....||||||.::.:|  ....|..:......|...|.||
Zfish   337 HPFFRNDQWTFSTIRETAAPVVPELSSDIDTSNFDEIEEDK--GEVETFPTPKAFVGNQLPFVGF 399

  Fly  1080 FEFTFRRFFDDKQPPDMTDDQAPV 1103
            ..|...:..:......|.:|. ||
Zfish   400 TYFKENQLLNAVNSSAMKNDH-PV 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	144/367 (39%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	126/305 (41%)
rock2a	NP_777288.1	STKc_ROCK2	25..403	CDD:270771	155/425 (36%)
		S_TKc	78..340	CDD:214567	126/305 (41%)
		DUF4631	431..1028	CDD:292090
		HR1_ROCK2	491..557	CDD:212028
		Rho_Binding	965..1032	CDD:286056
		PH_ROCK	1141..1246	CDD:269948
		C1	1250..1304	CDD:237996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920