DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wts and Mast2

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	XP_017448927.2	Gene:	Mast2 / 313819	RGDID:	1304573	Length:	1861	Species:	Rattus norvegicus

Alignment Length:	1004	Identity:	256/1004 - (25%)
Similarity:	369/1004 - (36%)	Gaps:	276/1004 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 PAPPP--RNPTACSAATPPPP--VPPTSQAYVKRRSP----ALNNRPPAIAPPTQR-----GNSP 247
            |.|||  |...|..||..|.|  :||      :||:|    .|..|...:...::.     |.||
  Rat    10 PQPPPARREDAAPRAAELPQPQSLPP------RRRAPPGRQLLEERSGPMGHDSREQDMVSGLSP 68

  Fly   248 VITQNGLKNP-----------QQQLTQ------------QLKSLNLYPGGGS-----GAVVEPPP 284
            ::.:. |.||           |:||:|            .|....|.|...|     |.|.
  Rat    69 LLFRK-LSNPDIFSPTGKAKLQRQLSQDDCKLRRGSLASSLSGKQLLPLSSSVHSSVGQVT---- 128

  Fly   285 PYLIQGGA-----------GGAAPPPPPPSYTASMQSRQSPTQ----------SQQSDYRKSPSS 328
             :...|.|           |.:|     ||.||.::....|.:          :..:.:..||||
  Rat   129 -WQSTGEASNLVRMRNQSLGQSA-----PSLTAGLKELSLPRRGSLISTLCRGADLTQHMFSPSS 187

  Fly   329 G--------IYSATSAGSPSPITVSLPPAPLAKPQPRVYQARSQQPIIMQSVKSTQVQKPVLQTA 385
            .        ..||....|.||:...|.|...:.|.........|......:.||..|......|.
  Rat   188 APALSLARVPLSADCVLSTSPLVFFLNPQAHSSPCSPCSSRTLQWSCRTSNRKSLIVTSSTSPTL 252

  Fly   386 VAPQSPSSASASNSPVHVLAAPPSYPQKSAAVVQQQQQAAAAAH-----QQQHQHQQSKPPTPTT 445
            ..|.||......|||   |.:|.::...            |.||     .:.|.|:..:..
  Rat   253 PRPHSPLHGHTGNSP---LDSPRNFSPN------------APAHFSFVPARSHGHRADRTD---- 298

  Fly   446 PPLVGLNSKPNCLEPPSYAKSMQAKAATVVQQQQQQQQQQQQVQQQQVQQQQQQQQQQLQALRVL 510
                  ..:.:....||........::||......|::..|...|....:           |..|
  Rat   299 ------GRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTADE-----------LHFL 346

  Fly   511 QAQAQRER--DQRERD---QRERERDQQKLANGNPGRQMLPPPPYQSN----NNNNSEIKPP--- 563
            ......|.  |:..|.   .|.|.|..      :|||.   |..:.|.    |:...|..|.
  Rat   347 TKHFSTENVPDEEGRQSPAMRPRSRSL------SPGRS---PVSFDSEIIMMNHVYKERFPKATA 402

  Fly   564 ----------SCNNNN------------------------IQISNSNLATTPPIPPAKYNNNSSN 594
                      |||..:                        :..|.|.|.|:......:.|.....
  Rat   403 QMEERLAEFISCNTPDSVLPLADGALSFIHHQVIEMARDCLDKSRSGLITSHYFYELQENLEKLL 467

  Fly   595 TGANSSGGSNGSTGTTASSSTSCKKIKHASPIPERKKISKEKEEERKEFRIRQYSPQAFKFFMEQ 659
            ..|:....|:    ..|......||:......|.|.            ....::.|:.|...:|.
  Rat   468 QDAHERSESS----DVAFVIQLVKKLMIIIARPARL------------LECLEFDPEEFYHLLEA 516

  Fly   660 ---HIE--NVIKSYRQRTYRKNQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSM- 718
               |.:  :.||....| |..:||       ||......||.::     |:|......:.|.|:
  Rat   517 AEGHAKEGHGIKCDIPR-YIVSQL-------GLTRDPLEEMVQL-----SSYDSPDTPETDDSVE 568

  Fly   719 ----------------FVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKA 767
                            |..:|.|..||:|.|.||....|... :|||.:.|.:::.|||:.....
  Rat   569 GRGASQPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQR-FAMKKINKQNLILRNQIQQAFV 632

  Fly   768 ERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLGIFEEELARFYIAEVTCAVD 832
            |||||..|:|.:||.::.||:.|.:|..||:|:.|||..:||..:|....::.|.|.||...|::
  Rat   633 ERDILTFAENPFVVSMFCSFETKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALE 697

  Fly   833 SVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQDSMEPWEEYSE 897
            .:|..|.:|||:||||:||...||||||||||......:..:..|:   .|..:|:.|
  Rat   698 YLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYE---GHIEKDARE------- 752

  Fly   898 NGPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPEVLERSGYTQLCDYWSVGVILYEMLVGQPPFL 962
                              .|...:.|||.||||||:.|.||.:..|:|::|:||||.|||..||.
  Rat   753 ------------------FLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFF 799

  Fly   963 ANSPLETQQKVIN----W-EKTLHIPPQAELSREATDLIRRLC-ASADKRLG-KSVDEVKSHDFF 1020
            .::|.|...:||:    | |....:||.|:      ||..:|. .:..:||| .|..|||.|.||
  Rat   800 GDTPEELFGQVISDEIVWPEGDDALPPDAQ------DLTSKLLHQNPLERLGTSSAYEVKQHPFF 858

  Fly  1021 KGIDFADMRKQKAPYIPEIKHPTDTSNFD 1049
            .|:|:..:.:|||.:||:::...|||.||
  Rat   859 MGLDWTGLLRQKAEFIPQLESEDDTSYFD 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	129/357 (36%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	114/307 (37%)
Mast2	XP_017448927.2	DUF1908	267..548	CDD:401031	58/349 (17%)
		STKc_MAST	584..863	CDD:270760	117/313 (37%)
		PDZ_signaling	1174..1255	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910