DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wts and Lats2

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_001100737.1	Gene:	Lats2 / 305922	RGDID:	1305906	Length:	1042	Species:	Rattus norvegicus

Alignment Length:	1110	Identity:	451/1110 - (40%)
Similarity:	555/1110 - (50%)	Gaps:	286/1110 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 QPGAGSISVSGVGVGVVGVANGRVPKMM---------TALMPNKLIRKPSIERDTASSHYLRCSP 147
            |.|:.||..:...:..:|..:.|..:::         ..|:|..:.|:||.|
  Rat   123 QTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLVPTAVTRRPSFE------------- 174

  Fly   148 ALDSGAGSSRSDSPHSHHTHQPSSRTVG--NPGGNGGFSPSP--------SGFSEVAPPA---PP 199
                |.|.:           .||...:|  |..|.......|        .|.|....||   ||
  Rat   175 ----GTGEA-----------FPSHHQLGGANYEGPAALEEMPRQYLDFLFPGASVHGAPAHQHPP 224

  Fly   200 PRNPTACSAATPPP-------PVPPTSQAYVKRRSPALNNRPPAIAPPTQRGNSPVITQNGLKNP 257
            ....||..|.|..|       .:......|..:|||:..::.|   |.|.  :|....|.|   |
  Rat   225 KGYSTAVDAGTHFPGAHYGRAHLLSEQPGYGVQRSPSFQSKTP---PDTY--SSLAKAQGG---P 281

  Fly   258 QQQLTQQLKSLNLYPGGGS---------GAVVEPPPPYLIQGGAGGAAPPPPPPSYTASMQSRQS 313
            ...||        :|....         .|.|....|..:.|..|        |::|.     .|
  Rat   282 PASLT--------FPAHAGLYTTSHHKPAAAVPGAHPLHVLGTRG--------PTFTG-----DS 325

  Fly   314 PTQSQQSDYRKSPSSGIYSATSAGSPSPITVSLPPAPLAKPQPRVYQARSQQPIIMQSVKSTQVQ 378
            .||:..:..|.|.::.:|   ..|||.|    .|.||||:          :..:..||::::
  Rat   326 STQAVLAPSRNSLNNDLY---ELGSPVP----WPAAPLAR----------RDSLQKQSLEAS--- 370

  Fly   379 KPVL---------QTAVAPQSPSSASASNSPVHVLAAPPSYPQKSAAVVQQQQQAAAAAHQQQHQ 434
            :|.:         .:..:||...|..|.|:...|.||...:|.||..|::.:.|.|..
  Rat   371 RPHVAFRAGPSRTNSFSSPQPEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVG------- 428

  Fly   435 HQQSKP---PTPTTPPLV-GLNSKPNCLEPPSYAKSMQAKAATVVQQQQQQQQQQQQVQQQQVQQ 495
              .|.|   |.||.|... ||.||.....||..
  Rat   429 --PSHPAWVPAPTAPAAAEGLESKEGSAGPPPL-------------------------------- 459

  Fly   496 QQQQQQQQLQALRVLQAQAQRERDQRERDQRERERDQQKLANGNPGRQMLPPPPYQSNNNNNSEI 560
                                      :.|....||             ..|||||..:
  Rat   460 --------------------------DMDFGGSER-------------RCPPPPYPKH------- 478

  Fly   561 KPPSCNNNNIQISNSNLATTPPIPPAKYNNNSSN-----TGANSS--GGS------NGSTGTTAS 612
                                 .:.|:|....|:.     ||...|  ||:      .|..|....
  Rat   479 ---------------------LLLPSKSEQYSAGLDRLCTGVEQSLRGGTEQDRNDKGHKGAKGD 522

  Fly   613 SSTSCKKIKHASPIPERKKISKEKEEERKEFRIRQYSPQAFKFFMEQHIENVIKSYRQRTYRKNQ 677
            .:...||....||:|.||   ..::||::|.||:.|||.|||||||||:|||||:|:|:..|:.|
  Rat   523 KAGRDKKQIQTSPVPVRK---NSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKVSRRLQ 584

  Fly   678 LEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGEVTLVSKIDTS 742
            ||:||.|.||.:..|.:|||:|.||||||.||||||||||||||:|.:|:||||||.|..|:||
  Rat   585 LEQEMAKAGLCETEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDT- 648

  Fly   743 NHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMS 807
            :.|||||||||.|||.|||||||||||||||||||.|||||||||||||:||||||||||||:||
  Rat   649 HALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMS 713

  Fly   808 LLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTH 872
            |||::.:|.|.||||||||:|.|::||||||||||||||||||||.|||||||||||||||||||
  Rat   714 LLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTH 778

  Fly   873 NSKYYQENGNHSRQDSMEP---WEEYS--ENGPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPEV 932
            ||||||: |||.|||||||   |::.|  ..|.:...||:|..:.|||.||||||||||||||||
  Rat   779 NSKYYQK-GNHIRQDSMEPGDLWDDVSNCRCGDRLKTLEQRAQKQHQRCLAHSLVGTPNYIAPEV 842

  Fly   933 LERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREATDLIR 997
            |.|.|||||||:|||||||:|||||||||||.:|.|||.||||||.|||||.|.:||.||.|||.
  Rat   843 LLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPTQVKLSAEARDLIT 907

  Fly   998 RLCASADKRLGK-SVDEVKSHDFFKGIDFA-DMRKQKAPYIPEIKHPTDTSNFDPVDPEK---LR 1057
            :||.:||.|||: ..|::|:|.||..|||: |:|||.|||:|.|.||.|||||||||.|.   ..
  Rat   908 KLCCAADCRLGRDGADDLKAHPFFSTIDFSRDIRKQPAPYVPTISHPMDTSNFDPVDEESPWHEA 972

  Fly  1058 SNDSTMSSGDDVDQNDR-TFHGFFEFTFRRFFDD----------KQPPDMTDDQ----------- 1100
            |.:|..:.......|.: ..|.|:||||||||||          .:|.:..|..
  Rat   973 SGESAKAWDTLASPNSKHPEHAFYEFTFRRFFDDNGYPFRCPKPSEPAESADPGDAELGGAVEGC 1037

  Fly  1101 APVYV 1105
            .||||
  Rat  1038 QPVYV 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	259/371 (70%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	228/306 (75%)
Lats2	NP_001100737.1	UBA_LATS2	101..141	CDD:270581	4/17 (24%)
		PHA03247	<143..490	CDD:223021	101/531 (19%)
		PKc_like	624..1004	CDD:419665	267/381 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	159	1.000	Domainoid score	I3991
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	694	1.000	Inparanoid score	I658
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	1	1.000	-	-		FOG0000273
OrthoInspector	1	1.000	-	-		otm44404
orthoMCL	1	0.900	-	-		OOG6_105652
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2473
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.970