DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wts and Sgk1

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	XP_006227785.1	Gene:	Sgk1 / 29517	RGDID:	3668	Length:	525	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	165/551 - (29%)
Similarity:	240/551 - (43%)	Gaps:	124/551 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   542 RQMLPPPPYQS-NNNNNSEIKPPSCNNNNIQISNSNLATTPPIPPAKYNNNSSNTGANSSGGSNG 605
            |.||.|...:| ......|:|.| ||:.||        .|.|.|...:.::..........|.|.
  Rat    76 RGMLSPEESRSWEIQPGGEVKEP-CNHANI--------LTKPDPRTFWTSDDPAFMKQRRMGLND 131

  Fly   606 STGTTASSSTSCKKIKHASPIPERKKISKEKEEERKEFRIRQYSPQAFKFFMEQHIENVIKSYRQ 670
            .....|::|.:||.       ||.:...|..:.:..|......||.
  Rat   132 FIQKLANNSYACKH-------PEVQSYLKISQPQEPELMNANPSPP------------------- 170

  Fly   671 RTYRKNQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGEVTL 735
                             |..:|     .:|...|:....|     .|.|..||.||.|:||:| |
  Rat   171 -----------------PSPSQ-----QINLGPSSNPHAK-----PSDFHFLKVIGKGSFGKV-L 207

  Fly   736 VSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAE-ADNNWVVKLYYSFQDKDNLYFVMDY 799
            :::.......||:|.|:|..:||:.:..|:.:||::|.: ..:.::|.|::|||..|.||||:||
  Rat   208 LARHKAEEAFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDY 272

  Fly   800 IPGGDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGL 864
            |.||:|...|.:...|.|..||||.||:..|:..:|.:..::||:||:|||:|..|||.||||||
  Rat   273 INGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGL 337

  Fly   865 CTGFRWTHNSKYYQENGNHSRQDSMEPWEEYSENGPKPTVLERRRMRDHQRVLAHSLVGTPNYIA 929
            |            :||..|              ||...|                 ..|||.|:|
  Rat   338 C------------KENIEH--------------NGTTST-----------------FCGTPEYLA 359

  Fly   930 PEVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREATD 994
            ||||.:..|.:..|:|.:|.:|||||.|.|||.:.:..|....::|  |.|.:.|  .::..|..
  Rat   360 PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN--KPLQLKP--NITNSARH 420

  Fly   995 LIRRLC-ASADKRLGKSVD--EVKSHDFFKGIDFADM--RKQKAPYIPEIKHPTDTSNFDPVDPE 1054
            |:..|. ....||||...|  |:|||.||..|::.|:  :|...|:.|.:..|:|..:|||...|
  Rat   421 LLEGLLQKDRTKRLGAKDDFMEIKSHIFFSLINWDDLINKKITPPFNPNVSGPSDLRHFDPEFTE 485

  Fly  1055 KL------RSNDSTMSSGDDVDQNDRTFHGF 1079
            :.      ||.||.:.:. .|.:....|.||
  Rat   486 EPVPSSIGRSPDSILVTA-SVKEAAEAFLGF 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	131/372 (35%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	111/304 (37%)
Sgk1	XP_006227785.1	S_TKc	192..449	CDD:214567	111/304 (37%)
Sgk1	XP_006227785.1	STKc_SGK	196..518	CDD:270727	130/369 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910