DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wts and sid2

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_592848.1	Gene:	sid2 / 2541599	PomBaseID:	SPAC24B11.11c	Length:	607	Species:	Schizosaccharomyces pombe

Alignment Length:	600	Identity:	173/600 - (28%)
Similarity:	284/600 - (47%)	Gaps:	107/600 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   542 RQMLPPPPYQSNNN---------NNSEIKPPSCNNNNIQISN------SNLATTPPIP------- 584
            |..|..|...|||:         |:.::.|.:.:..|...::      |.|....|||
pombe    32 RHGLFEPGNLSNNDKERNLEDQFNSMKLSPVASSKENYPDNHMHSKHISKLPIASPIPRGLDRSG 96

  Fly   585 PAKYNNNSSNTGANSSGGSNGSTGTTASSSTSCKKIKHASPIPERKKISKEKEEERKEFRIRQYS 649
            ...|.:|:..:..:|:|......|:                    ..:|.|:.|:..:.::::.:
pombe    97 ELSYKDNNHWSDRSSTGSPRWENGS--------------------MNLSVEEMEKVVQPKVKRMA 141

  Fly   650 PQAFKFFMEQHIENV----IKSYRQRTYRKNQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLK 710
            .....||::.:.|.:    .:..|.|.: :.||.||      ||..:.|:.|..|.:|..|:|.:
pombe   142 TICQMFFLDHYFEQLHYLYTRKQRARLF-EEQLLKE------PDSRRDELVKRYNGRERVYLRKR 199

  Fly   711 RAKMDKSMFVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEA 775
            |.::....|..:..:|.|.:|.|.|..|.|| ..:.|:|.:.|:.:.|.:::.||..|||||..|
pombe   200 RTRISHGDFQTITQVGQGGYGSVWLARKRDT-KEIVALKIMNKSVLHKMDEIRHVLTERDILTTA 263

  Fly   776 DNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFI 840
            ::.|:|:|.|:|||..|:|..|:::||||..:||...|:..:..|:||..|:..|:|::|::|:|
pombe   264 NSEWLVRLLYAFQDTSNIYLAMEFVPGGDFRTLLSNSGVLRDHHAKFYATEMFLAIDALHQLGYI 328

  Fly   841 HRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQDSMEPWEEYSENGPKPTVL 905
            |||:||:|.|:...||||||||||.:|..            :..:.:||:...:...|    .|:
pombe   329 HRDLKPENFLVGASGHIKLTDFGLSSGII------------SKKKIESMKIRLQEVNN----VVV 377

  Fly   906 ERRRMRDHQRVL----------AHSLVGTPNYIAPEVLERSGYTQLCDYWSVGVILYEMLVGQPP 960
            ..|.||:.::|.          |||:||:|:|:|||||....|....||||:|.|:||.|.|.||
pombe   378 PERSMRERRQVFRTLLSQDPVYAHSVVGSPDYMAPEVLRGENYNHSVDYWSLGCIMYECLSGFPP 442

  Fly   961 FLANSPLETQQKVINWEKTL---HIPPQAELS----REATDLIRRLCASADKRLGKSVDEVKSHD 1018
            |..::..||...:.||.|..   |.....:|.    .:|.|.:.. |.:..|....|:.:|..|.
pombe   443 FSGSNVNETWSNLKNWRKCFQRPHYDDPRDLEFNWRDDAWDFVCH-CITDPKDRFCSLKQVMQHP 506

  Fly  1019 FFKGIDFADMR-KQKAPYIPEIKHPTDTSNFDPVDPEKLRSNDSTMSSGDDVDQND-------RT 1075
            :|..||:.::| ..:.|::|::....|...||..      :|::.||...:|.:..       .|
pombe   507 YFSKIDWKNVRTAYRPPFVPDLNSEIDAGYFDDF------TNENDMSKYKEVHEKQAAIANMVNT 565

  Fly  1076 F-----HGFFEFTFR 1085
            |     :.|..||||
pombe   566 FNKPKRNAFIGFTFR 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	128/390 (33%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	113/317 (36%)
sid2	NP_592848.1	STKc_Sid2p_like	196..581	CDD:270751	134/408 (33%)
sid2	NP_592848.1	S_TKc	208..508	CDD:214567	113/317 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910