DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wts and gad8

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_588010.1	Gene:	gad8 / 2539206	PomBaseID:	SPCC24B10.07	Length:	569	Species:	Schizosaccharomyces pombe

Alignment Length:	622	Identity:	175/622 - (28%)
Similarity:	279/622 - (44%)	Gaps:	167/622 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   514 AQRERDQRERDQRERERDQQKLANGNPGRQMLPPPPYQSNNNNNSEIKPPSCN---NNNIQISNS 575
            :::..|::.|...|.:|..|... ..||  :|.....::.|     :|.||.:   |..:.|.||
pombe    41 SRKSSDEKSRKSSEDKRSPQSTV-VQPG--LLQVTIIEARN-----LKLPSGHVPANYGVSIDNS 97

  Fly   576 NLATTPPIPPAKYNNNSSNTGANSSGGSNGSTGTTASSSTSCKKIKHASPIP------ERKKI-- 632
            .||  ||:                   |||| |...|.|       ||..:|      ::.:|
pombe    98 LLA--PPL-------------------SNGS-GHARSRS-------HAWWLPYIVVEFDKNEILV 133

  Fly   633 ------SKEKE--EERKEFRIRQYSPQAFKFFMEQHIENVIKSYRQR----------------TY 673
                  |.|..  :.:..|.:.:||..:...::..      .|.|.|                ::
pombe   134 DALNTASLENPCWDYQATFDVSRYSKLSLNIYLRS------SSSRSRNGMGNDAFLGGIKLSPSF 192

  Fly   674 RKNQLEKE---MHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGEVTL 735
            ..|:|..|   :|  |...:.:::|....||.         ..:....|..||.:|.|:||:|..
pombe   193 IVNKLTDEWVPLH--GGSGELRVQMLYKPNQS---------TPLTIDAFELLKVVGKGSFGKVMQ 246

  Fly   736 VSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYI 800
            |.|.||| .:||:||::||.::.|::|.|..|||.:||:.:|.::|.|.:|||....||.|:.::
pombe   247 VRKRDTS-RIYALKTMKKAHIVSRSEVDHTLAERTVLAQVNNPFIVPLKFSFQSPGKLYLVLAFV 310

  Fly   801 PGGDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLC 865
            .||:|...|.:.|.|:...|:|||||:..|::.:|:...|:||:||:|||:|..|||.|.|||||
pombe   311 NGGELFHHLQREGCFDTYRAKFYIAELLVALECLHEFNVIYRDLKPENILLDYTGHIALCDFGLC 375

  Fly   866 TGFRWTHNSKYYQENGNHSRQDSMEPWEEYSENGPKPTVLERRRMRDHQRVLAHSLVGTPNYIAP 930
                          ..|.::.|.                             .::..|||.|:||
pombe   376 --------------KLNMAKTDR-----------------------------TNTFCGTPEYLAP 397

  Fly   931 EVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREATDL 995
            |:|...|||::.|:|::||:||||:.|.|||...:..|..:|::  :..|..|.  .:..:|.||
pombe   398 ELLLGHGYTKVVDWWTLGVLLYEMITGLPPFYDENINEMYRKIL--QDPLRFPD--NIDEKAKDL 458

  Fly   996 IRRLCASA-DKRLGK-SVDEVKSHDFFKGIDFADM--RKQKAPYIPEIKHPTDTSNFD------- 1049
            :..|...| :||||. ...|:|:|.||..||:..:  :|.:.|:.|.::...||||||
pombe   459 LSGLLTRAPEKRLGSGGAQEIKNHPFFDDIDWKKLCAKKIQPPFKPSVESAIDTSNFDSEFTSEI 523

  Fly  1050 PVDPEKLRSN----------------DSTMSSGDDVD 1070
            |:|.....|:                .:|:.:.||::
pombe   524 PMDSVVADSHLSETVQQRFANWSYQRPTTIDTSDDIN 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	128/381 (34%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	109/302 (36%)
gad8	NP_588010.1	YPK1_N_like	66..225	CDD:212165	42/211 (20%)
		PTZ00263	214..545	CDD:140289	128/387 (33%)
		STKc_YPK1_like	235..547	CDD:270737	122/359 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910