DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wts and Cdc42bpg

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_001028514.1	Gene:	Cdc42bpg / 240505	MGIID:	2652845	Length:	1551	Species:	Mus musculus

Alignment Length:	396	Identity:	148/396 - (37%)
Similarity:	220/396 - (55%)	Gaps:	76/396 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   708 RLKRAKMDKSMFVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDIL 772
            ::|..::.:..|..||.||.||||||.:|.: ..|..::|||.|.|.::|||.:.|..:.|||:|
Mouse    60 KVKELRLQRDDFEILKVIGRGAFGEVAVVRQ-RGSGQIFAMKMLHKWEMLKRAETACFREERDVL 123

  Fly   773 AEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLGIFEE----ELARFYIAEVTCAVDS 833
            .:.|:.||..|:|:|||::.||.||||..||||::||.:   ||:    |||:||:||:..|:.|
Mouse   124 VKGDSRWVTALHYAFQDEEYLYLVMDYYAGGDLLTLLSR---FEDRLPPELAQFYLAEMVLAIHS 185

  Fly   834 VHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQDSMEPWEEYSEN 898
            :|::|::|||:||||||:|.:|||:|.|||.|.
Mouse   186 LHQLGYVHRDVKPDNILLDMNGHIRLADFGSCL-------------------------------- 218

  Fly   899 GPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPEVLE-----RSGYTQLCDYWSVGVILYEMLVGQ 958
                      |:.::..|.:...||||:||:||:|:     :..|...||:||:||..||:|.|:
Mouse   219 ----------RLNNNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGE 273

  Fly   959 PPFLANSPLETQQKVINWEKTLHIPPQ-AELSREATDLIRRLCASADKRLGK-SVDEVKSHDFFK 1021
            .||.|.|.:||..|::|.|..|..|.. .::...|.||||:|....::|||: .:|:.:.|.||:
Mouse   274 TPFYAESLVETYGKIMNHEDHLQFPADVTDVPASAQDLIRQLLCRQEERLGRGGLDDFRKHPFFE 338

  Fly  1022 GIDFADMRKQKAPYIPEIKHPTDTSNFDPVDPEKLRSNDSTMSSGDDVDQNDRTFHGFFE----- 1081
            |:|:..:....||||||::.|.|||||| ||.:.|...::...|.          ||.|.
Mouse   339 GVDWERLATSTAPYIPELRGPMDTSNFD-VDDDTLNRPETLPPSS----------HGAFSGHHLP 392

  Fly  1082 ---FTF 1084
               ||:
Mouse   393 FVGFTY 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	142/371 (38%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	121/311 (39%)
Cdc42bpg	NP_001028514.1	STKc_DMPK_like	69..399	CDD:270748	147/387 (38%)
		S_TKc	71..337	CDD:214567	121/311 (39%)
		Taxilin	452..774	CDD:286771
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	578..605
		DMPK_coil	743..798	CDD:117396
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	820..886
		C1_1	878..926	CDD:278556
		PH_MRCK	937..1069	CDD:269949
		CNH	1096..1359	CDD:279162
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1441..1551
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920