DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wts and Rock1

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_033097.1	Gene:	Rock1 / 19877	MGIID:	107927	Length:	1354	Species:	Mus musculus

Alignment Length:	408	Identity:	153/408 - (37%)
Similarity:	227/408 - (55%)	Gaps:	63/408 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   695 MRKMLNQKESNYI--------RLKRAKMDKSMFVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTL 751
            :||  |:...|::        :::..:|....:..:|.||.||||||.|| :..::..:||||.|
Mouse    46 LRK--NKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLV-RHKSTRKVYAMKLL 107

  Fly   752 RKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLGIFE 816
            .|.:::||:..|....||||:|.|::.|||:|:|:|||...||.||:|:|||||::|:....: .
Mouse   108 SKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-P 171

  Fly   817 EELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHNSKYYQENG 881
            |:.||||.|||..|:|::|.|||||||:||||:|:|:.||:||.|||.|
Mouse   172 EKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTC---------------- 220

  Fly   882 NHSRQDSMEPWEEYSENGPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPEVLERSG----YTQLC 942
                                      .:|.....|...:.||||:||:||||:..|    |.:.|
Mouse   221 --------------------------MKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGREC 259

  Fly   943 DYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREATDLIRRLCASADKRL 1007
            |:|||||.|||||||..||.|:|.:.|..|::|.:.:|..|...::|:||.:||.......:.||
Mouse   260 DWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRL 324

  Fly  1008 GKS-VDEVKSHDFFKGIDFA--DMRKQKAPYIPEIKHPTDTSNFDPVDPEKLRSNDSTMSSGDDV 1069
            |:: |:|:|.|.|||...:|  .:|...||.:|::....||||||.::.:|  .::.|.......
Mouse   325 GRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDK--GDEETFPIPKAF 387

  Fly  1070 DQNDRTFHGFFEFTFRRF 1087
            ..|...|.||..::.||:
Mouse   388 VGNQLPFVGFTYYSNRRY 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	144/367 (39%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	126/305 (41%)
Rock1	NP_033097.1	STKc_ROCK1	2..406	CDD:270772	153/408 (38%)
		S_TKc	76..338	CDD:214567	126/305 (41%)
		Interaction with FHOD1. /evidence=ECO:0000250	368..727		10/40 (25%)
		Smc	<422..>1097	CDD:224117
		HR1_ROCK1	489..554	CDD:212029
		SHROOM3 binding. /evidence=ECO:0000269\|PubMed:22493320	707..946
		Rho_Binding	949..1014	CDD:286056
		RHOA binding. /evidence=ECO:0000250	998..1010
		Auto-inhibitory. /evidence=ECO:0000250	1115..1354
		PH_ROCK	1119..1225	CDD:269948
		C1	1229..1283	CDD:237996
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1333..1354
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920