DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wts and kin-4

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_001255551.1	Gene:	kin-4 / 178068	WormBaseID:	WBGene00002192	Length:	1831	Species:	Caenorhabditis elegans

Alignment Length:	1258	Identity:	304/1258 - (24%)
Similarity:	471/1258 - (37%)	Gaps:	307/1258 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KYTAEALESIKQDL---TRFEVQNNHRNNQNYTPLRYTATNGRNDALTPDYHHAKQPMEP--PPS 74
            |..:.|.|..|..|   .||.:|.......:.:|.|    :.|...|:......:..::|  ||.
Worm    12 KSPSNATEKPKSYLHPYRRFSMQPTSTYRTSLSPQR----SPRLKRLSEQLSQIRISLDPPSPPF 72

  Fly    75 ASPAP--DVVIPPPPAI------VGQPGAGSISVSGVGVGVVGVANGRVPKMMTALMPNKLIRKP 131
            .||:|  |..:...|.:      .||....|....|.|..:.|  |.         :|::.:..|
Worm    73 LSPSPLGDYRVNDEPRMHYLQVPGGQADDNSPEFRGGGAFLFG--NN---------LPSRFLSSP 126

  Fly   132 SIERDTASSHYLRCSPALDSGAGSSRSDSPHSHHTHQPSSRTVGNPGGNGGFSPSPSGFSEVAPP 196
            ..:|.|:.:              |:.||:        .||.|:          |..|.:..:..|
Worm   127 PPDRRTSFA--------------STMSDT--------NSSITI----------PMSSSYQNLLSP 159

  Fly   197 APPPRNPTACSAATPP-PPVPPTSQAYVKRRSPA-LNNRPPAIAPPTQ----RGNSPVITQNGL- 254
            .......::....||| .|.|..|::.:..||.: ..|.||.:..|..    |..||.::.:..
Worm   160 MWSTMKYSSDDNETPPNEPSPRRSKSALSNRSSSDCINVPPIVFSPVLSRPIRSMSPTMSMSPTF 224

  Fly   255 -----KNPQQQLTQQLKSLNLY-----PGG----GSGAVVEPP------PPYLIQGGAGGAAPP- 298
                 .:.:.....|...:.|:     ..|    |||:::.||      |    |||.|..:..
Worm   225 RTHHNSDSESDTGAQAAGVCLFACTSSASGLVWKGSGSLMIPPRRSFHRP----QGGGGNDSSDS 285

  Fly   299 ---------------------PPPPSYTASMQSRQSPTQSQ---------QSDYRKSPSSGIYSA 333
                                 ...|..||:.....|.:.:.         .||.:.|.||.....
Worm   286 NSNVERLLKRNRRRTMAIHGVETEPGQTAASTGWTSASMTNLCRVRSSLGHSDPQLSSSSTNSFN 350

  Fly   334 TSAGSPSPITVSLPPAPLAKPQPRVYQARSQQPIIMQSVKSTQVQKPVLQTAVAPQSPSSA---- 394
            ||..|..|.|.|...|..:.......::.:.:|.:..|.....:|:......|..:|.||:
Worm   351 TSTSSLHPATKSSTTALSSFSTSSANRSPANRPSLHSSTSPVTLQRCRSPMRVPQRSTSSSHNFG 415

  Fly   395 ------SASNSPVH----VLAAPPSYPQKSA----AVVQQQQQAAAAAHQQQHQHQQSKPP---- 441
                  |:|.|.||    .|:...:|..::.    |.||..::.:.|          |.|.
Worm   416 AAGAGPSSSGSSVHSGTITLSVCRTYSARNGSSLMAPVQDTRRWSLA----------SLPSTSGY 470

  Fly   442 -TPTTPPLVGLNSKPNCLEPPSYAKSM-------QAKAATVVQQQQQQQQQQQQVQQQQVQQQQQ 498
             ||.|....|::|:        |:.|.       |.:.:..|:|...:.............||..
Worm   471 GTPGTGSNSGVSSQ--------YSSSEQIGEMLDQTRISGPVRQNSSRFDSNDSYDDMASHQQAA 527

  Fly   499 QQQQQLQALR------------------VLQAQAQRERDQRERDQRERERDQQKLANGNPGRQML 545
            .|...|...|                  |.:....:||..|.:.|.| ||....:|...|   :.
Worm   528 AQNAFLNRPRSRSLTSPMKFLNEYNIEMVNRTSVYKERFPRAKLQME-ERLNAFVAENGP---LS 588

  Fly   546 PPPPYQSNNNNNSEIKPPSCNNNNIQISNSNLATTPPIPPAKYNNNSSNT--------------- 595
            .....||..::...:...|...:.   |:|.|.....:..|...:..|..
Worm   589 GGISQQSARDDTDRVDDLSARQSG---SSSGLKAKDSVEEAVMRSRRSTVLEAESYADRSLLRLI 650

  Fly   596 --GA-------------NSSGGSNG----------------STGTTASSSTSCKKIKHASPIPER 629
              ||             :..|.|..                .|...|...||.:.:::.|.:.
Worm   651 GDGATRFLHHQIVEIALDCLGKSKDDLITCSYFCEMSQRLEETLNEAQMKTSPESLEYLSKLV-- 713

  Fly   630 KKISKEKEEERKEFRIRQYSPQAFKFFMEQHIENVIK-SYRQRTYRKNQLEKE-MHKVGLPDQTQ 692
            ||:........:.....::.|..|...:|: .|.|:: .....|.|...|.:. :.|:||.....
Worm   714 KKLLMIVSRPARLLECLEFDPDEFYHLLEE-AEGVVREQLGSGTARVPDLPQYIIGKLGLDRDPL 777

  Fly   693 IEMRKMLNQKESNYI----------------RLKRAKMDKSMFVKLKPIGVGAFGEVTLVSKIDT 741
            |:..:.::..|:.:.                ...||..:.. |..::.:..||:|.|.||...:|
Worm   778 IDSTEHVDSSENTHATTSGTTSAKGAGSAWQETNRAPCEDD-FDTIRLVSNGAYGAVYLVRHRET 841

  Fly   742 SNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLM 806
            ... :|:|.:.|..::.||||..|.||||||..|||.:||..|.||:.:..|..:|:|:.|||..
Worm   842 RQR-FALKKMNKQTLMLRNQVDQVFAERDILTMADNPFVVSFYGSFETRQYLCMLMEYVEGGDCA 905

  Fly   807 SLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWT 871
            :||...|....||.|.|:||...|::.:|..|.:|||:||||:||...||||||||||
Worm   906 ALLKSAGTLPVELVRLYVAETILAIEYLHSYGIVHRDLKPDNLLITAMGHIKLTDFGL------- 963

  Fly   872 HNSKYYQENGNHSRQDSMEPWEEYSENGPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPEVLERS 936
              ||.    |..:|...:.  |.|.      .|:|.::.:|.|      |.|||.||||||:.|.
Worm   964 --SKI----GLMNRTTLVA--EGYD------AVVETQQFQDKQ------LCGTPEYIAPEVILRR 1008

  Fly   937 GYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAE-LSREATDLIRRLC 1000
            ||.:..|:|::|:||||.|||..||...:|.....|||:  :.:..|.:.| |..||.||.|||.
Worm  1009 GYGKPVDWWALGIILYEFLVGIVPFFGETPEALFSKVIS--EDVEYPEEDEALPPEAADLCRRLL 1071

  Fly  1001 -ASADKRLG--KSVDEVKSHDFFKGIDFADMRKQKAPYIPEIKHPTDTSNFDP-VDPEKLRSNDS 1061
             .:..:|||  ....::.:|:||..:||..:.:|||.::|::.:..|||.||. .|    |.|..
Worm  1072 EKNPAERLGTLNGAAQLMAHEFFILLDFTSLLRQKAEFVPQLDNEEDTSYFDTRTD----RYNHE 1132

  Fly  1062 TMSSGDD-----VDQNDRTFHGF 1079
            ..|.|::     ...:...||.|
Worm  1133 AESCGEEEIVGSSAASSMMFHSF 1155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	139/370 (38%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	120/304 (39%)
kin-4	NP_001255551.1	DUF1908	455..779	CDD:286070	58/351 (17%)
		STKc_MAST	818..1099	CDD:270760	122/311 (39%)
		S_TKc	819..1094	CDD:214567	120/304 (39%)
		PDZ_signaling	1434..1521	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920