DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wts and DMPK

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_001275693.1	Gene:	DMPK / 1760	HGNCID:	2933	Length:	655	Species:	Homo sapiens

Alignment Length:	363	Identity:	138/363 - (38%)
Similarity:	207/363 - (57%)	Gaps:	53/363 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   700 NQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAH 764
            ::.|...:|||..::.:..|..||.||.|||.||.:| |:..:..:||||.:.|.|:|||.:|:.
Human    78 SRAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVV-KMKQTGQVYAMKIMNKWDMLKRGEVSC 141

  Fly   765 VKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLG-IFEEELARFYIAEVT 828
            .:.|||:|...|..|:.:|:::|||::.||.||:|..||||::||.|.| ....|:||||:||:.
Human   142 FREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV 206

  Fly   829 CAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQDSMEPWE 893
            .|:||||::|::||||||||||:||.|||:|.|||.|.
Human   207 MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCL--------------------------- 244

  Fly   894 EYSENGPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPEVLERSG-------YTQLCDYWSVGVIL 951
                           ::|....|.:...||||:|::||:|:..|       |...||:|::||..
Human   245 ---------------KLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFA 294

  Fly   952 YEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAE-LSREATDLIRRLCASADKRLGK-SVDEV 1014
            |||..||.||.|:|..||..|::::::.|.:|...| :..||.|.|:||....:.|||: ...:.
Human   295 YEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDF 359

  Fly  1015 KSHDFFKGIDFADMRKQKAPYIPEIKHPTDTSNFDPVD 1052
            ::|.||.|:|:..:|....|:.|:.:..|||.|||.|:
Human   360 RTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVE 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	134/346 (39%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	120/310 (39%)
DMPK	NP_001275693.1	STKc_DMPK_like	95..432	CDD:270748	134/346 (39%)
		S_TKc	97..365	CDD:214567	120/310 (39%)
		DMPK_coil	496..556	CDD:117396
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920