DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wts and Lats1

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_034820.1	Gene:	Lats1 / 16798	MGIID:	1333883	Length:	1129	Species:	Mus musculus

Alignment Length:	1279	Identity:	496/1279 - (38%)
Similarity:	605/1279 - (47%)	Gaps:	382/1279 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GEKRGGR--------PNDKY---TAEALESIKQ---------DLTRFEVQNNHRNNQNYTPLRYT 49
            |||..|.        |...|   :.:.|:.|::         |.::.|...|..:.::...:|..
Mouse     4 GEKPEGYRQMRPKTFPASNYPGSSRQMLQEIRESLRNLSKPSDASKAEHNLNKMSTEDPRQVRNP 68

  Fly    50 ATNGRNDALTPDYHHAKQPMEPPPSASPAPDVVIPPPPAIVGQPGAG----------------SI 98
            ...|.:.....:..::..|.....|:|.:|..|  .|........||                ||
Mouse    69 PKFGTHHKALQEIRNSLLPFANETSSSRSPSEV--NPQMFQDLQAAGFDEDMVIQALQKTNNRSI 131

  Fly    99 SVSGVGVGVVGVANGRVPKM-MTALMPNKLIRKP-----SIERDTASSHYLRCSPALDSGAGSSR 157
            ..:...:..:...:.|..:| ..|..|.....||     ||.|.             .|..||..
Mouse   132 EAAVEFISKMSYQDPRREQMSAAAARPINATMKPGNVQHSINRK-------------QSWKGSKE 183

  Fly   158 SDSPHSH----------HTHQPSSRT-VGNPGGNGGFS---------------PSPSGFSEVAPP 196
            |..|..|          .:..|:|:. ||.|....|.:               |.|.....|.||
Mouse   184 SLVPQRHGPSLGENVVYRSESPNSQADVGRPLSGSGIAAFAQAHPSNGQRVNPPPPPQVRSVTPP 248

  Fly   197 APPPRNPTACSAATPPPPV--PPTSQA---------YVKRRSPALNNRPPAI----APPTQRGNS 246
             ||||..|.....|.|||.  .|:||.         .:.|.||.    ||..    .||.....|
Mouse   249 -PPPRGQTPPPRGTTPPPPSWEPSSQTKRYSGNMEYVISRISPV----PPGAWQEGYPPPPLTTS 308

  Fly   247 PVITQNGLKNPQQQ---------------LTQQLKSLNLYP-------GGG-----------SGA 278
            |:       ||..|               :.|.....|..|       |||           :|:
Mouse   309 PM-------NPPSQAQRAISSVPVGRQPIIMQSTSKFNFTPGRPGVQNGGGQSDFIVHQNVPTGS 366

  Fly   279 VV-EPPPPYLIQGGAG--------GAAPPPP----------------------------PPSYTA 306
            |. :|||||.:....|        ||:..||                            |...||
Mouse   367 VTRQPPPPYPLTPANGQSPSALQTGASAAPPSFANGNVPQSMMVPNRNSHNMELYNINVPGLQTA 431

  Fly   307 SMQSRQSPTQSQQSDYRKSP------------------SSGIYSATSAGSPSPITVSLPPAPLAK 353
            ..||..:|.||..|...:.|                  |...:||.|..|.:.:| ::.|||:
Mouse   432 WPQSSSAPAQSSPSGGHEIPTWQPNIPVRSNSFNNPLGSRASHSANSQPSATTVT-AITPAPI-- 493

  Fly   354 PQPRVYQARSQQPIIMQSVKSTQVQKPVLQTAVAPQSPSSASASNSPVHVLAAPPSYPQKSAAVV 418
                      |||     |||.:|.||.||||:||..||...   .||..: .|..:.:.:|:.|
Mouse   494 ----------QQP-----VKSMRVLKPELQTALAPTHPSWMP---QPVQTV-QPTPFSEGTASSV 539

  Fly   419 QQQQQAAAAAHQQQHQHQQSKPPTPTTPPLVGLNSKPNCLEPPSYAKSMQAKAATVVQQQQQQQQ 483
                                    |..||:.         |.|||..
Mouse   540 ------------------------PVIPPVA---------EAPSYQG------------------ 553

  Fly   484 QQQQVQQQQVQQQQQQQQQQLQALRVLQAQAQRERDQRERDQRERERDQQKLANGNPGRQMLPPP 548
                                                                          |||
Mouse   554 --------------------------------------------------------------PPP 556

  Fly   549 PYQSNNNNNSEIKPP------SCNNNNIQISNSNLATTPPIPPAKYNNNSSNTGANSSGGSNGST 607
            ||..:..:.:...||      .|.:..           |.:|....:..|:::|  .||......
Mouse   557 PYPKHLLHQNPSVPPYESVSKPCKDEQ-----------PSLPKEDDSEKSADSG--DSGDKEKKQ 608

  Fly   608 GTTASSSTSCKKIKHASPIPERKKISKEKEEERKEFRIRQYSPQAFKFFMEQHIENVIKSYRQRT 672
            .||             |||..||   .:|:|||:|.||:.|||||||||||||:|||:||::||.
Mouse   609 ITT-------------SPITVRK---NKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRL 657

  Fly   673 YRKNQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGEVTLVS 737
            :||.|||.||.:|||....|.:|||||.|||||||||||||||||||||:|.:|:||||||.|..
Mouse   658 HRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLAR 722

  Fly   738 KIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPG 802
            |:|| ..|||.|||||.|||.|||||||||||||||||||.|||:||||||||||||||||||||
Mouse   723 KVDT-KALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPG 786

  Fly   803 GDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTG 867
            ||:|||||::|||.|.||||||||:||||:|||||||||||||||||||||||||||||||||||
Mouse   787 GDMMSLLIRMGIFPENLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTG 851

  Fly   868 FRWTHNSKYYQENGNHSRQDSMEPWEEYSEN-----GPKPTVLERRRMRDHQRVLAHSLVGTPNY 927
            |||||:||||| :|:|.|||||:...|:.:.     |.:...||||..|.|||.|||||||||||
Mouse   852 FRWTHDSKYYQ-SGDHPRQDSMDFSNEWGDPSNCRCGDRLKPLERRAARQHQRCLAHSLVGTPNY 915

  Fly   928 IAPEVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREA 992
            ||||||.|:|||||||:|||||||:|||||||||||.:|||||.|||||:.:|||||||:||.||
Mouse   916 IAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEA 980

  Fly   993 TDLIRRLCASADKRLGKS-VDEVKSHDFFKGIDF-ADMRKQKAPYIPEIKHPTDTSNFDPVDPEK 1055
            :|||.:||...:.||||: .||:|:|.|||.||| :|:|:|.|.|||:|.|||||||||||||:|
Mouse   981 SDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDK 1045

  Fly  1056 LRSNDSTMSSGDDV-----DQNDRTFHGFFEFTFRRFFDDKQPP 1094
            |.|:.|...:..|.     .......|.|:||||||||||...|
Mouse  1046 LWSDGSEEENISDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGYP 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	264/372 (71%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	230/306 (75%)
Lats1	NP_034820.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71		12/66 (18%)
		UBA_like_SF	103..143	CDD:304366	5/39 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	148..216		19/80 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..276		17/48 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..317		9/31 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..407		12/43 (28%)
		PPxY motif 1	372..375		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	432..492		14/60 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..630		41/262 (16%)
		Interaction with YAP1. /evidence=ECO:0000250	525..654		56/271 (21%)
		PPxY motif 2	555..558		2/2 (100%)
		STKc_LATS1	702..1083	CDD:270775	272/382 (71%)
		S_TKc	704..1009	CDD:214567	230/306 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1104..1129
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831916
Domainoid	1	1.000	153	1.000	Domainoid score	I4275
eggNOG	1	0.900	-	-		E1_KOG0608
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	688	1.000	Inparanoid score	I697
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	1	1.000	-	-		FOG0000273
OrthoInspector	1	1.000	-	-		otm42343
orthoMCL	1	0.900	-	-		OOG6_105652
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4821
SonicParanoid	1	1.000	-	-		X2473
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.790