DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wts and AgaP_AGAP000406

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	XP_310694.5	Gene:	AgaP_AGAP000406 / 1271840	VectorBaseID:	AGAP000406	Length:	1394	Species:	Anopheles gambiae

Alignment Length:	466	Identity:	157/466 - (33%)
Similarity:	229/466 - (49%)	Gaps:	113/466 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   659 QHIENVIKSYRQRTYRKNQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLK 723
            ::||..||.|:...               .|.|.:.|..                 |...|:||
Mosquito    54 KNIETFIKRYKSLA---------------TDITSLRMNP-----------------DDFTFIKL- 85

  Fly   724 PIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQ 788
             ||.|:||||.||.: ..:..:||||.|.|..:|.|:..|....||.|:|.|:::|:|||:|:||
Mosquito    86 -IGRGSFGEVLLVRQ-KATRQVYAMKRLSKYQMLTRSDTAFFWEERYIMANANSDWIVKLHYAFQ 148

  Fly   789 DKDNLYFVMDYIPGGDLMSLLIKLGIFE--EELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILI 851
            |...||.|||::||||::.|   :.::|  |:.|.||..||..|:|::|:|||||||:||||:|:
Mosquito   149 DAKYLYMVMDFMPGGDIVGL---MNVYEIPEKWALFYTMEVVLALDTIHQMGFIHRDVKPDNMLL 210

  Fly   852 DRDGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQDSMEPWEEYSENGPKPTVLERRRMRDHQRV 916
            |:.||:||.|||.|                                          .||.|...|
Mosquito   211 DKYGHLKLADFGTC------------------------------------------MRMDDDGLV 233

  Fly   917 LAHSLVGTPNYIAPEVLE----RSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWE 977
            .:.:.||||:||:||||:    :.||.:.||:||||:.|||:|:|..||.::|.:.|..|:::.:
Mosquito   234 RSSNAVGTPDYISPEVLQFQGVKGGYGRECDWWSVGIFLYEILIGDTPFFSDSLVGTYGKIMDHK 298

  Fly   978 KTLHIPPQAELSREATDLIRRLCASADKRLGK-SVDEVKSHDFFKG--IDFADMRKQKAPYIPEI 1039
            ..|..|..|.:|..|..||:...:....|||: ||:|:|||.||:.  ..|.::|:...|.:||:
Mosquito   299 NCLEFPDNARISENAKSLIKGFLSDRTVRLGRHSVEEIKSHPFFENDTWTFENLRQSVPPVVPEL 363

  Fly  1040 KHPTDTSNFDPVDPEKLRSNDSTMSSGDDVDQNDRTFHG----FFEFTFRRFFD----------- 1089
            ....||.||:.|   |.:|:..|..      ....||.|    |..||:...:.
Mosquito   364 SSDDDTRNFEEV---KRKSSIGTNF------PTPTTFAGDHLPFIGFTYSPDYQLLAGEPEPADG 419

  Fly  1090 DKQPPDMTDDQ 1100
            |....|.||::
Mosquito   420 DGSAGDTTDNR 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	140/369 (38%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	123/307 (40%)
AgaP_AGAP000406	XP_310694.5	STKc_ROCK	54..404	CDD:270747	153/438 (35%)
		S_TKc	80..342	CDD:214567	123/309 (40%)
		SbcC	<445..1018	CDD:223496
		Rho_Binding	958..1021	CDD:286056
		PH_ROCK	1123..1222	CDD:269948
		C1	1237..1285	CDD:237996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D36525at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920