DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wts and CIT

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	XP_011536085.1	Gene:	CIT / 11113	HGNCID:	1985	Length:	2084	Species:	Homo sapiens

Alignment Length:	465	Identity:	147/465 - (31%)
Similarity:	224/465 - (48%)	Gaps:	117/465 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   646 RQYSPQA--------FKFFME---------QHIENVIKSYRQRTYRKNQLEKEMHKVGLPDQTQI 693
            :|.||.:        |..|.|         :|:.|.::.|........:|:        |.....
Human    41 QQMSPLSREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQ--------PSAKDF 97

  Fly   694 EMRKMLNQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLK 758
            |:|.:                          :|.|.|.||.:|.:..|.: :||||.::|..:|.
Human    98 EVRSL--------------------------VGCGHFAEVQVVREKATGD-IYAMKVMKKKALLA 135

  Fly   759 RNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKL-GIFEEELARF 822
            :.||:..:.||:||:.:.:.|:.:|.|:||||::||.||:|.|||||:|||.:. ...:|.|.:|
Human   136 QEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQF 200

  Fly   823 YIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQD 887
            |:||:..||.|||.||::||||||:|||:||.|||||.|||
Human   201 YLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFG------------------------ 241

  Fly   888 SMEPWEEYSENGPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPEVLE------RSGYTQLCDYWS 946
                              ...:|..::.|.|...:|||:|:|||||.      :..|...||:||
Human   242 ------------------SAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWS 288

  Fly   947 VGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREATDLIRRLCASADKRLGKSV 1011
            ||||.|||:.|:.||...:...|...::|:::.|..|...::|.:..|||:.|.....:||  ..
Human   289 VGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERL--KF 351

  Fly  1012 DEVKSHDFFKGIDFADMRKQKAPYIPEIKHPTDTSNFDPVDPEK---LRSNDSTMS----SGDDV 1069
            :.:..|.||..||:.::|....|::|.:|...||||||  :|||   :.|:...:|    ||:::
Human   352 EGLCCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFD--EPEKNSWVSSSPCQLSPSGFSGEEL 414

  Fly  1070 DQNDRTFHGF 1079
                 .|.||
Human   415 -----PFVGF 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	132/374 (35%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	110/307 (36%)
CIT	XP_011536085.1	STKc_CRIK	95..422	CDD:270752	136/403 (34%)
		S_TKc	97..360	CDD:214567	112/333 (34%)
		Smc	474..1335	CDD:224117
		C1	1405..1453	CDD:237996
		PH	1486..1605	CDD:278594
		CNH	1650..1946	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920