DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wts and Mast4

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	XP_038959885.1	Gene:	Mast4 / 103690045	RGDID:	9344213	Length:	2684	Species:	Rattus norvegicus

Alignment Length:	1068	Identity:	274/1068 - (25%)
Similarity:	417/1068 - (39%)	Gaps:	271/1068 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 SPAL---DSGAGSSRSDSPHSHHTHQPSSRTVGNPGGNGGFSPSPSGFSEVAPPAPP-----PRN 202
            |||.   ..||.|:.|.|         .|.|:...|..|.||      ....||.||     .|.
  Rat    26 SPAAAVSSEGASSAESSS---------GSETLSEEGEPGRFS------CRSQPPRPPGGALGSRL 75

  Fly   203 PTACSAA------------TPPP-----PVPPTSQAYVKRRSPALNN--RPPAIAPPTQRGNSPV 248
            |.|.:.|            .|||     |||..|.|..:.:...|::  .||.:  |.::.::|.
  Rat    76 PAAWAPARVVLERGVPTLPLPPPGGAVLPVPRVSSASQEEQDEELDHILSPPPM--PFRKCSNPD 138

  Fly   249 IT---QNGLKNPQQQLTQQLKSLNLYPGGG--SGAVVEPPPPYLIQGGA---------------- 292
            :.   ...||. ::||::..|.|.....||  :|..:.|.|   :.|.|
  Rat   139 VACGLGKSLKY-KRQLSEDGKQLRRGSLGGALTGRYLLPNP---VAGQAWPASAETSNLVRMRSQ 199

  Fly   293 --GGAAPP-------PPPPSYTASMQSRQ---SPTQSQQS----------DYRK--------SPS 327
              |.:||.       .||.|:..|.:.||   .|..|::.          |.:|        :|.
  Rat   200 ALGQSAPSLTASLEGQPPKSHFNSARHRQRLVDPAASKKELSLPRRGSLVDSQKWNCLVKRLTPR 264

  Fly   328 SGIYSATSAGSPSPITVSLPPAPLAKPQPRVYQARSQQPIIMQSVKSTQVQKPVLQTAVAPQSPS 392
            |        .||:|.:...|.:||........:..:::.:|...      |.|.|.   .|.||.
  Rat   265 S--------LSPTPSSPGSPCSPLLTFHFWSCRTTNRKSLISNG------QSPALP---RPHSPL 312

  Fly   393 SASASNSPVHVLAAPPSYPQKSAAVVQQQQQAAAAAHQQQHQHQQSKPPTPTTPPLVGLNSKPNC 457
            ||.|.|||..   :|.::...::|     ..:.|..:.:....:.|....|::.  .|.|:
  Rat   313 SAHAGNSPQD---SPRNFSPSASA-----HFSFARRNDRTDGRRWSLASLPSSG--YGTNT---- 363

  Fly   458 LEPPSYAKSMQAKAATVVQQQQQQQQQQQQVQQQQVQQQQQQQQQQLQALRVLQAQAQRERDQRE 522
               ||          :.|......|::..|:..|....:.....:.......:..    |...|.
  Rat   364 ---PS----------STVSSSCSSQEKLHQLPYQPTPDELHFLSKHFCTTESIAT----ENRCRN 411

  Fly   523 RDQRERERDQQKLANGNPGRQMLPPPPYQSNNNNNSEIKPPSCNNNNIQISNSNLATTPPIPPAK 587
            ...|.|.|..      :|||.                   |:|.::.|.:.|.......|...|:
  Rat   412 TPMRPRSRSL------SPGRS-------------------PACCDHEIIMMNHVYKERFPKATAQ 451

  Fly   588 YNNN-----SSNTGANSSGGSNGSTGTT----ASSSTSCKKIKHASPIPER------KKISK--E 635
            ..:.     :|.:..|....::|....|    ...:..|....|...|..|      .|:.|  :
  Rat   452 MEDRLKEIVTSYSPDNVLPLADGVLSFTHHQIIELARDCLDKSHQGLITSRYFLELQHKLDKLLQ 516

  Fly   636 KEEERKE------------------------FRIRQYSPQAFKFFME---------QHIENVIKS 667
            :..:|.|                        ....::.|:.|.:.:|         |.|::.|..
  Rat   517 EAHDRSESGELAFIKQLVRKILIVIARPARLLECLEFDPEEFYYLLEAAEGHAKEGQGIKSDIPR 581

  Fly   668 Y--RQRTYRKNQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLK-RAKMDKSMFVKLKPIGVGA 729
            |  .|....|:.|| ||.::|..|....|..:......|:...|: |.|..:|.|..:|.|..||
  Rat   582 YIISQLGLNKDPLE-EMAQLGNYDSRTAETPETDESVSSSNTSLRLRRKPRESDFETIKLISNGA 645

  Fly   730 FGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLY 794
            :|.|..| :...|...:|||.:.|.:::.|||:.....|||||..|:|.:||.:|.||:.:.:|.
  Rat   646 YGAVYFV-RHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETRRHLC 709

  Fly   795 FVMDYIPGGDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKL 859
            .||:|:.|||..:|:..:|....::||.|.||...|::.:|..|.:|||:||||:|:...|||||
  Rat   710 MVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKL 774

  Fly   860 TDFGLCTGFRWTHNSKYYQENGNHSRQDSMEPWEEYSENGPKPTVLERRRMRDHQRVLAHSLVGT 924
            |||||......:..:..|:   .|..:|:.|                         .|...:.||
  Rat   775 TDFGLSKVGLMSMTTNLYE---GHIEKDARE-------------------------FLDKQVCGT 811

  Fly   925 PNYIAPEVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKV----INWEKTLHIPPQ 985
            |.||||||:.|.||.:..|:|::|:||||.|||..||..::|.|...:|    |||.:....||.
  Rat   812 PEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPPP 876

  Fly   986 AELSREATDLIRRLCASAD-KRLGK-SVDEVKSHDFFKGIDFADMRKQKAPYIPEIKHPTDTSNF 1048
                 :|.|||..|..... :|||. ...|||.|.||:.:|:..:.:|||.:||:::...|||.|
  Rat   877 -----DAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLDWNSLLRQKAEFIPQLESEDDTSYF 936

  Fly  1049 DPVDPEKLRSNDSTMSSGDDVDQNDRTF 1076
            | ...||...    |.:.::.|.||..|
  Rat   937 D-TRSEKYHH----METEEEDDTNDEDF 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	133/366 (36%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	112/306 (37%)
Mast4	XP_038959885.1	DUF1908	320..596	CDD:401031	51/332 (15%)
		STKc_MAST	634..913	CDD:270760	114/312 (37%)
		PDZ_signaling	1211..1289	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910