DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wts and lats2

DIOPT Version :9

Sequence 1:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	XP_012811721.1	Gene:	lats2 / 100124721	XenbaseID:	XB-GENE-994907	Length:	1117	Species:	Xenopus tropicalis

Alignment Length:	1104	Identity:	448/1104 - (40%)
Similarity:	576/1104 - (52%)	Gaps:	200/1104 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 QPGAGSISVSGVGVGVVGV---ANGRVPKMMTALMPNKLIRKPSIERDTASSHYLRCSPALDSGA 153
            |.|:.||..:...:..:|.   .|.::.:::....|.|:....|:      ||.....
Frog   124 QTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKVTPPNSV------SHRANFE------- 175

  Fly   154 GSSRSDSPHSHHTHQPSSRTVGNPG----GNGGFSPSPSGFSEVAPPAPPPRNPTACSAATPP-- 212
            ||:.:.||:    |..::.....||    |....|..|..:.:....:|.|......|....|
Frog   176 GSNETFSPY----HPVNNAAYEGPGFAAEGANVLSEVPRQYMDYLLSSPQPATLNGPSQRPLPVV 236

  Fly   213 ----PPVPPTSQAYVKRRSPAL-------NNRPPAIAPPTQRGNSPVITQNGLK---NPQQQLTQ 263
                .||....:.||.....|:       :|.|..........:||..::..:.   :|.....|
Frog   237 GAHNSPVSHQQKGYVTNAESAVINYVIGSHNSPGLPIQTPHASSSPHYSRQHMMVQGDPMGYSVQ 301

  Fly   264 QLKSL--NLYPGGGSGAVVEPPPPYLIQGGAGGAAPP------PPPPSYTASMQSRQSPTQSQQS 320
            :..|.  .:...||...:.:..|.:.......|...|      ..|||:...:.||.||..::.|
Frog   302 RTPSFQNKMQQDGGYVNIPQTSPGHAYTQAPSGLYMPHTHHKQTSPPSHQMHVISRGSPYGNEFS 366

  Fly   321 D--------YRKSPSSGIYSATSAGSPS-PITVSLP-PAPLAKPQPRV-YQARSQQPIIMQSVKS 374
            |        .|.|.:..:|...:|...| |...||. |...:.|:..| ::..||.|....|..:
Frog   367 DTPQALLTPSRNSLNMDLYDIGNAWQNSQPCRDSLQGPGLDSSPRQHVSFRPDSQVPSRTNSFNN 431

  Fly   375 TQVQKPVLQTAVAPQSP-SSASASNSPVHVLAAPPSYPQKSAAVVQQQQQAAAAAHQQQHQHQQS 438
            .|.||.|:.....|..| ||.:|.|:...|.:.....|.||..|.:.:.|.|
Frog   432 HQQQKQVVMRQTPPNKPDSSMTAPNTVTTVTSTHILQPVKSMRVARPEPQTA------------- 483

  Fly   439 KPPTPTTPPLVGLNSKPNCLEPPSYAKSMQAKAATVVQQQQQQQQQQQQVQQQQVQQQQQQQQQQ 503
                      ||          ||:...:.|:|              |:::.|:|:..:......
Frog   484 ----------VG----------PSHPSWLAAQA--------------QKLETQKVEMVEPHTSSM 514

  Fly   504 LQALRVLQAQAQRERDQRERDQRERERDQQKLANGNPGRQMLPPPPYQ-----SNNNNNSEIKPP 563
            ..|...........:|.|                       .|||||.     .||....|:. .
Frog   515 GAANAYGMDVGYGNQDMR-----------------------FPPPPYPKHLLLQNNPEQHELN-A 555

  Fly   564 SCN--NNNIQISNSNLATTPPIPPAKYNNNSSNTGANSSGGSNGSTGTTASSSTSCKKIKHASPI 626
            .|.  :.|:::|.:     .|..|....|........|      .|.....|....|:|: .||:
Frog   556 LCKGMDQNLRVSEN-----VPCGPVDEANGEPKPSKVS------KTPKVVKSGKDKKQIQ-TSPV 608

  Fly   627 PERKKISKEKEEERKEFRIRQYSPQAFKFFMEQHIENVIKSYRQRTYRKNQLEKEMHKVGLPDQT 691
            |.||   ..::||::|.||:.|||.|:||:||||:|||:|:|:|:..|:.|||:||.:.||.:..
Frog   609 PVRK---NSRDEEKRESRIKSYSPFAYKFYMEQHVENVLKTYQQKINRRLQLEQEMAEAGLCEAI 670

  Fly   692 QIEMRKMLNQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADV 756
            |.:|||:|.||||||.||||||||||:|||:|.:|:||||||.|.||:|| ..|||||||||.||
Frog   671 QEQMRKILYQKESNYNRLKRAKMDKSLFVKIKTLGIGAFGEVCLASKVDT-KALYAMKTLRKKDV 734

  Fly   757 LKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLGIFEEELAR 821
            |.|||||||||||||||||||.|||||||||||||:||||||||||||:|||||::.:|.|.|||
Frog   735 LNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLAR 799

  Fly   822 FYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQ 886
            |||||:|.|::||||||||||||||||||||.|||||||||||||||||||||||||: |||:||
Frog   800 FYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQK-GNHARQ 863

  Fly   887 DSMEP---WEEYS--ENGPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPEVLERSGYTQLCDYWS 946
            |||||   |::.|  ..|.:...||:|..|.|.|.|||||||||||||||||.|.|||||||:||
Frog   864 DSMEPSELWDDVSNCRCGDRLKTLEQRAKRQHHRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWS 928

  Fly   947 VGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREATDLIRRLCASADKRLGKS- 1010
            |||||:|||||||||||::|.|||.|||:||.|||||.|..||.|||:||..||..|:.|||::
Frog   929 VGVILFEMLVGQPPFLASNPTETQLKVIHWENTLHIPSQINLSPEATNLITALCCGAEDRLGRNG 993

  Fly  1011 VDEVKSHDFFKGIDF-ADMRKQKAPYIPEIKHPTDTSNFDPVDPEK--LRSNDST------MSSG 1066
            .||:|:|.||..:|| :|:|.|.|||:|:|.||.||||||||:.|.  ..|.|||      ||||
Frog   994 PDEIKAHPFFISMDFSSDIRHQPAPYVPKISHPMDTSNFDPVEEENPCNDSGDSTVTWDTLMSSG 1058

  Fly  1067 DDVDQNDRTFHGFFEFTFRRFFDDKQPP--------------DMTDDQ-----------APVYV 1105
                 |..|.|.|:||||||||||...|              :.|:::           .||||
Frog  1059 -----NKHTEHAFYEFTFRRFFDDHGYPFRYPKPSKLETSSCEETEEEDKNASRESEGCQPVYV 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	262/375 (70%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	228/306 (75%)
lats2	XP_012811721.1	UBA_LATS2	102..142	CDD:270581	4/17 (24%)
lats2	XP_012811721.1	PKc_like	696..1075	CDD:419665	270/385 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	458	1.000	Domainoid score	I485
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	641	1.000	Inparanoid score	I804
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	1	1.000	-	-		FOG0000273
OrthoInspector	1	1.000	-	-		otm47451
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2473
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.070