DRSC/TRiP Functional Genomics Resources

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Protein Alignment zfh1 and ZEB2

DIOPT Version :10

Sequence 1:NP_733401.3 Gene:zfh1 / 43650 FlyBaseID:FBgn0004606 Length:1206 Species:Drosophila melanogaster
Sequence 2:NP_055610.1 Gene:ZEB2 / 9839 HGNCID:14881 Length:1214 Species:Homo sapiens


Alignment Length:1237 Identity:325/1237 - (26%)
Similarity:493/1237 - (39%) Gaps:335/1237 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   110 ESDAEDEQSNMSGSSRRYAKSPLASNNNSSTANANNNSTSSQSMNNNSELAKNHNSANKMSPMCS 174
            |:|.||:               |....:...||..:..||..|:       .||.|:..:|....
Human    37 ETDEEDK---------------LHIAEDDGIANPLDQETSPASV-------PNHESSPHVSQALL 79

  Fly   175 PGSLTPGDL-FAQLQHP-------------PPQLPPHLHAQFMAAAASLAMQSARTASSPSQQQQ 225
            |......:: ...::||             |.::..........|....|:.:....::......
Human    80 PREEEEDEIREGGVEHPWHNNEILQASVDGPEEMKEDYDTMGPEATIQTAINNGTVKNANCTSDF 144

  Fly   226 QQLQQQQQLQQQQQHQMAMQQLLP--------PQLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTT 282
            ::...:::|:::..|.:::::.|.        |:.|...|.:|:..|     :.......|..|.
Human   145 EEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEA-----NGQEENDLPPGTP 204

  Fly   283 GDLSGAYPCMQCTASFASREQLEQH-EQLHSPCGPAAVSNVSQTCRICHKAFANVYRLQRHMISH 346
            ...:....|..|...:.....|::| :..|..      :..:.:|.:|...||...:|:|||::|
Human   205 DAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEK------NEENFSCPLCSYTFAYRTQLERHMVTH 263

  Fly   347 ----DESALL------RKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSH 401
                |:..:|      |||||.||.||||:|||||||:||||||||:.|.||.||||||||:|||
Human   264 KPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSH 328

  Fly   402 MTSKKC---ISMGLKLNNNRALLKRLEKSPGSASSA-------SRRSPSDHGKG-KLPEQPSLPG 455
            ::||||   ||:..::.||    .:...||.|.||:       ..|:..::||. .:.||..|..
Human   329 ISSKKCIGLISVNGRMRNN----IKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLK 389

  Fly   456 L-PHPMSYFASDAQV--------------QGGSAAPAPFPPFHPNY----------MNAALLAFP 495
            : ..|:.:  :|.:|              .||..|.:|. ..||:.          |.|.||.||
Human   390 IKTEPLDF--NDYKVLMATHGFSGTSPFMNGGLGATSPL-GVHPSAQSPMQHLGVGMEAPLLGFP 451

  Fly   496 HNFMAAAAGLDPRVHPYSIQRLLQL--SAAGQQQREEEREEQQKQQQHDEEETPDEPKLVMDIEE 558
                ...:.|.      .:|::||:  :...:|:.:.:.||..|.:.:..::...:|:     |:
Human   452 ----TMNSNLS------EVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPE-----EQ 501

  Fly   559 PETKEMAPT--------PEATEAATPIKREESREA-----SPDPESYRSSSQAIKQEQEPL--NV 608
            ..|....|.        ..||::......|:..||     |...:|.|..|...|::...|  .|
Human   502 GVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLV 566

  Fly   609 AEERQTPVEEHAPVEHAADLRCSRCSKQFNHPTELVQHEKVLCGL---IKEELEQH--FQQQQAT 668
            .:::.  :|.|   ..:....|..|.:.|..|..|.|||:.||.:   ||..|:.|  ....:|.
Human   567 TDDKM--IENH---NISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAG 626

  Fly   669 SFALASASEEDEEDEEMDVEEEPRQESGERKVRVRTAIN--EEQQQQLKQHYSLNARPSRDEFRM 731
            .|.          |.:..:......|.|     :.:.||  ::....||.:|::|..|:.||...
Human   627 VFV----------DNKALLLSSVLSEKG-----MTSPINPYKDHMSVLKAYYAMNMEPNSDELLK 676

  Fly   732 IAARLQLDPRVVQVWFQNNRSRERKMQSFQNNQ-----------AAGAAPP-----------MPI 774
            |:..:.|....|:.||:     :||:..:.|::           |..:.||           .|:
Human   677 ISIAVGLPQEFVKEWFE-----QRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPM 736

  Fly   775 DSQAS------------------LTR--------------------------------------- 782
            ||..|                  ||:                                       
Human   737 DSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRSNTPSPLNLSSTSSKNSHSSSY 801

  Fly   783 ----------EDQPLDLSVKRDPLTPK-----------SESSPPYIAPPSGEALNPEAINLS--- 823
                      :.:|||||:.:....||           |..|..:.:..|....:.|.:||:   
Human   802 TPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPLNLTFIK 866

  Fly   824 RKFSTS-----ASMSPA-SISPSSAAALYFGAAPPPS--PPNSQLDSTPRSGQAFPGLPPY--ML 878
            ::||.|     .|.:|. |::|.||..|| .|.||.|  ||.:.:   |....:.|||.||  :.
Human   867 KEFSNSNNLDNKSTNPVFSMNPFSAKPLY-TALPPQSAFPPATFM---PPVQTSIPGLRPYPGLD 927

  Fly   879 PMS-LPMEALFKMRPGGDFASNHALMNSIKLPDYRGTSLSPGGSEKRSWRDD----DSRISHEDE 938
            .|| ||..|.........||.........:...::| .|..|..:..|..||    ||.:|.   
Human   928 QMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQG-ELLDGAQDYMSGLDDMTDSDSCLSR--- 988

  Fly   939 FGAGVLMPPKPRRGKAETHGHAGDPDLPYVCDQCDKAFAKQSSLARHKYEHSGQRPYQCIECPKA 1003
                       ::.|....|       .|.||.|||.|.|.|||.||||||:|:||:||..|.||
Human   989 -----------KKIKKTESG-------MYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKA 1035

  Fly  1004 FKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYREXVSDTSVPPTCQPG 1068
            |||||||.||.||||||||:||.||.|||||||||||||||||||||  || ....:.....:..
Human  1036 FKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCK--REAEEREAAEREAREK 1098

  Fly  1069 ANPLAPPAMASNRGRRRVQVPAGNPPYTPHHQHPHHPHLAAMAAFQQQHQQQQQQHQHHRLSWNG 1133
            .: |.|..:..||...:...|.|   |:...:....|            :..:.:.:|.:...:|
Human  1099 GH-LEPTELLMNRAYLQSITPQG---YSDSEERESMP------------RDGESEKEHEKEGEDG 1147

  Fly  1134 GG 1135
            .|
Human  1148 YG 1149

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zfh1NP_733401.3 C2H2 Zn finger 291..311 CDD:275368 4/20 (20%)
C2H2 Zn finger 326..346 CDD:275368 8/19 (42%)
zf-H2C2_2 338..365 CDD:463886 16/36 (44%)
zf-C2H2 355..377 CDD:395048 17/21 (81%)
C2H2 Zn finger 357..377 CDD:275368 15/19 (79%)
zf-H2C2_2 369..391 CDD:463886 16/21 (76%)
Homeodomain 701..756 CDD:459649 14/56 (25%)
C2H2 Zn finger 969..989 CDD:275368 14/19 (74%)
zf-H2C2_2 981..1006 CDD:463886 17/24 (71%)
C2H2 Zn finger 997..1017 CDD:275368 14/19 (74%)
zf-H2C2_2 1009..1034 CDD:463886 19/24 (79%)
C2H2 Zn finger 1025..1042 CDD:275368 14/16 (88%)
ZEB2NP_055610.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..101 17/85 (20%)
zf-Di19 209..263 CDD:428539 13/59 (22%)
C2H2 Zn finger 213..234 CDD:275368 4/20 (20%)
zf-C2H2 241..263 CDD:395048 8/21 (38%)
C2H2 Zn finger 243..263 CDD:275368 8/19 (42%)
zf-C2H2 282..304 CDD:395048 17/21 (81%)
C2H2 Zn finger 284..304 CDD:275368 15/19 (79%)
zf-H2C2_2 296..319 CDD:463886 17/22 (77%)
SMAD-MH2 binding domain. /evidence=ECO:0000250 437..487 14/59 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 702..740 7/37 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 771..810 0/38 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 832..857 3/24 (13%)
C2H2 Zn finger 1001..1021 CDD:275368 14/19 (74%)
zf-H2C2_2 1013..1038 CDD:463886 17/24 (71%)
C2H2 Zn finger 1029..1049 CDD:275368 14/19 (74%)
zf-H2C2_2 1041..1066 CDD:463886 19/24 (79%)
C2H2 Zn finger 1057..1074 CDD:275368 14/16 (88%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1117..1214 7/48 (15%)

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