DRSC/TRiP Functional Genomics Resources

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Protein Alignment zfh1 and ZEB1

DIOPT Version :10

Sequence 1:NP_733401.3 Gene:zfh1 / 43650 FlyBaseID:FBgn0004606 Length:1206 Species:Drosophila melanogaster
Sequence 2:NP_001167567.1 Gene:ZEB1 / 6935 HGNCID:11642 Length:1125 Species:Homo sapiens


Alignment Length:1120 Identity:293/1120 - (26%)
Similarity:421/1120 - (37%) Gaps:295/1120 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    92 HIASEHP-HDKLNCGAAQPESDAEDEQSNMSGSSRRYAKSPLASNNNSSTANANNNSTSSQSMNN 155
            ||..|.. .|..:|... ||.|...:|:.:.|.|         |....:..|...:.|..:..  
Human    40 HIVEEESVTDAADCEGV-PEDDLPTDQTVLPGRS---------SEREGNAKNCWEDDTGKEGQ-- 92

  Fly   156 NSELAKNHNSANKMSPMCSPGSLTPGDLFAQLQHPPPQLPPHLHAQFMAAAASLAMQSARTASSP 220
                                          ::..|..|          |..|...::.....|..
Human    93 ------------------------------EILGPEAQ----------ADEAGCTVKDDECESDA 117

  Fly   221 SQQQQQQLQQQQQLQQQQQHQMAMQQLLPPQLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDL 285
            ..:|......::.||||.      ..::.|:.|..:...|:..|         |......|....
Human   118 ENEQNHDPNVEEFLQQQD------TAVIFPEAPEEDQRQGTPEA---------SGHDENGTPDAF 167

  Fly   286 SGAYPCMQCTASFASREQLEQH-EQLHSPCGPAAVSNVSQTCRICHKAFANVYRLQRHMISH--- 346
            |....|..|...:.....|::| :..|..      :..:.:|.:|...||...:|:|||.||   
Human   168 SQLLTCPYCDRGYKRFTSLKEHIKYRHEK------NEDNFSCSLCSYTFAYRTQLERHMTSHKSG 226

  Fly   347 ------DESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSK 405
                  .:|...|||||.||.||||:|||||||:||||||||:.|.||.||||||||:|||::||
Human   227 RDQRHVTQSGCNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSK 291

  Fly   406 KCISM---------GLKLNNNRALLKRLEKSPGSASSASRRSPSDHGKGKLPEQPSLPGL-PHPM 460
            ||||:         |||  .::.....|..||||.:....|...::  ..|.||.|:..: ..|:
Human   292 KCISLIPVNGRPRTGLK--TSQCSSPSLSASPGSPTRPQIRQKIEN--KPLQEQLSVNQIKTEPV 352

  Fly   461 SYFASDAQVQGGSAAPAP-----FPPFHPNYMNAALLAFPHNFMAAAAGLDPRVHPYS-----IQ 515
            .|......|..|.....|     |....|....::........:....||   |.|.|     ||
Human   353 DYEFKPIVVASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGL---VSPISINLSDIQ 414

  Fly   516 RLLQLSAAGQQQREEEREEQQKQQQHDEEETPDEP-----------------------KLVMDIE 557
            .:|:::..|...|:.....|......::|.....|                       |::::..
Human   415 NVLKVAVDGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYS 479

  Fly   558 EPETKEMAPTPEATEAATPIKREESREASPDPESYRSSSQAIKQEQ--EPLNVAEERQTPVEEHA 620
            ..:..::...|:..:...|:                 ::.:.|.|:  |.|.|..|:....|  .
Human   480 LEQPSQLQVVPQNLKKENPV-----------------ATNSCKSEKLPEDLTVKSEKDKSFE--G 525

  Fly   621 PVEHAADLRCSRCSKQFNHPTELVQHEKVLCGLIKEELEQHFQQQQATSFALASASEEDEEDEEM 685
            .|..:..|.|..|....|...||                :|:..:|.|......|:|.::.:..:
Human   526 GVNDSTCLLCDDCPGDINALPEL----------------KHYDLKQPTQPPPLPAAEAEKPESSV 574

  Fly   686 -----DVEEEPRQESGERKVRVRTAINEEQQQQLKQHYSLNARPSRDEFRMIAARLQLDPRVVQV 745
                 |....|.|...:..:.:           ||.:|:|||:||.:|...||..:.|...||:.
Human   575 SSATGDGNLSPSQPPLKNLLSL-----------LKAYYALNAQPSAEELSKIADSVNLPLDVVKK 628

  Fly   746 WFQNNRSRERKMQSFQ--------------NN---QAAGA------------------APPMPID 775
            ||:..::.:..:||.:              ||   |:|.|                  :|.:|:.
Human   629 WFEKMQAGQISVQSSEPSSPEPGKVNIPAKNNDQPQSANANEPQDSTVNLQSPLKMTNSPVLPVG 693

  Fly   776 S----QASLTREDQPLDLSVKRDP----LTPKSESSPPYIAP-------PSGEALNPEAINLSRK 825
            |    ..|.|....||:||..|:.    .|.:.....|.:.|       ..||.|....|....:
Human   694 STTNGSRSSTPSPSPLNLSSSRNTQGYLYTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQ 758

  Fly   826 FST-SASMSPASISPSSAAALYFGAAPPPSPPNSQLDSTPRSGQAFPGLPPYMLPMSLPMEALFK 889
            .|. |....|.::|         .|...|...:...||.|    ....:||...|:::.:..:..
Human   759 NSVYSVQEEPLNLS---------CAKKEPQKDSCVTDSEP----VVNVIPPSANPINIAIPTVTA 810

  Fly   890 MRPG----GD---------FASNHALMNSIKLPDYR---GTSLSPGGSE----------KRSWRD 928
            ..|.    .|         .|:|   ..:|.:|...   .|::||...|          .:..|.
Human   811 QLPTIVAIADQNSVPCLRALAAN---KQTILIPQVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQ 872

  Fly   929 DDSR--ISHEDEFGAGVLMPPKPRRGKAETHGHAGDPDLPYVCDQCDKAFAKQSSLARHKYEHSG 991
            |.|.  :|:.::.......|||.:..|.|..        .|.||.|||.|.|.|||.||||||:|
Human   873 DTSSEGVSNVEDQNDSDSTPPKKKMRKTENG--------MYACDLCDKIFQKSSSLLRHKYEHTG 929

  Fly   992 QRPYQCIECPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYREXV 1056
            :||::|..|.|||||||||.||.||||||||:||.||.|||||||||||||||||||||...| .
Human   930 KRPHECGICKKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEER 994

  Fly  1057 SDTSVPPTCQPGANP 1071
            ..|.     |..|.|
Human   995 DSTE-----QEEAGP 1004

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zfh1NP_733401.3 C2H2 Zn finger 291..311 CDD:275368 4/20 (20%)
C2H2 Zn finger 326..346 CDD:275368 8/19 (42%)
zf-H2C2_2 338..365 CDD:463886 16/35 (46%)
zf-C2H2 355..377 CDD:395048 17/21 (81%)
C2H2 Zn finger 357..377 CDD:275368 15/19 (79%)
zf-H2C2_2 369..391 CDD:463886 16/21 (76%)
Homeodomain 701..756 CDD:459649 16/54 (30%)
C2H2 Zn finger 969..989 CDD:275368 14/19 (74%)
zf-H2C2_2 981..1006 CDD:463886 16/24 (67%)
C2H2 Zn finger 997..1017 CDD:275368 14/19 (74%)
zf-H2C2_2 1009..1034 CDD:463886 19/24 (79%)
C2H2 Zn finger 1025..1042 CDD:275368 14/16 (88%)
ZEB1NP_001167567.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 143..164 4/29 (14%)
C2H2 Zn finger 173..194 CDD:275368 4/20 (20%)
zf-C2H2 201..223 CDD:395048 8/21 (38%)
C2H2 Zn finger 203..223 CDD:275368 8/19 (42%)
zf-C2H2 241..263 CDD:395048 17/21 (81%)
C2H2 Zn finger 243..263 CDD:275368 15/19 (79%)
zf-H2C2_2 255..278 CDD:463886 17/22 (77%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 305..328 8/24 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 552..587 6/34 (18%)
Homeodomain 582..630 CDD:459649 16/58 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 637..715 16/77 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 857..899 7/41 (17%)
C2H2 Zn finger 907..927 CDD:275368 14/19 (74%)
zf-H2C2_2 919..944 CDD:463886 16/24 (67%)
zf-C2H2 933..955 CDD:395048 14/21 (67%)
C2H2 Zn finger 935..955 CDD:275368 14/19 (74%)
zf-H2C2_2 947..972 CDD:463886 19/24 (79%)
C2H2 Zn finger 963..980 CDD:275368 14/16 (88%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 990..1125 5/20 (25%)

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