DRSC/TRiP Functional Genomics Resources

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Protein Alignment zfh1 and PRDM16

DIOPT Version :9

Sequence 1:NP_733401.3 Gene:zfh1 / 43650 FlyBaseID:FBgn0004606 Length:1206 Species:Drosophila melanogaster
Sequence 2:NP_071397.3 Gene:PRDM16 / 63976 HGNCID:14000 Length:1276 Species:Homo sapiens


Alignment Length:1141 Identity:238/1141 - (20%)
Similarity:354/1141 - (31%) Gaps:393/1141 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   272 PRSTSSPGSTTGDLSGAYPCMQCTASFASREQLEQH-----------------EQLHSPCGPAAV 319
            |..|..||.   |....:.|.:|...|.|:..|.:|                 |:| .|.|....
Human   216 PLGTVPPGL---DEEPTFRCDECDELFQSKLDLRRHKKYTCGSVGAALYEGLAEEL-KPEGLGGG 276

  Fly   320 SNVSQTCRICHKAFANVYRLQRHMISHDESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFG 384
            |..:..|:.|.:.|.|.|.|::||:.|.|.   |::||.:|.|||.:|.:|..|...|...|.|.
Human   277 SGQAHECKDCERMFPNKYSLEQHMVIHTEE---REYKCDQCPKAFNWKSNLIRHQMSHDSGKRFE 338

  Fly   385 CDNCGKRFSHSGSFSSHMTSKK---------------CISMGLKLN------------------- 415
            |:||.|.|:...:...|:.|:.               ..|.|||.:                   
Human   339 CENCVKVFTDPSNLQRHIRSQHVGARAHACPDCGKTFATSSGLKQHKHIHSTVKPFICEVCHKSY 403

  Fly   416 ---NNRALLKRLE---------KSPG----SASSASRRSPSDHGKGKLPE----QPSLPGLPHPM 460
               :|....||:.         |..|    :.||.::......||.....    .|.||..|.||
Human   404 TQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHYTPGGIFAPGLPLTPSPM 468

  Fly   461 ------------------SYFASDAQVQGG---SAAPAPFPPFHPNYMN---------------A 489
                              .||.|... .|.   |.||..||...|.:..               .
Human   469 MDKAKPSPSLNHASLGFNEYFPSRPH-PGSLPFSTAPPTFPALTPGFPGIFPPSLYPRPPLLPPT 532

  Fly   490 ALLAFPHNFMAAAAGLDPRVHP-----YSIQRLLQ--LSAAGQQQREEER-----EEQQKQQQHD 542
            :||..|.|....|....|..:|     .::....|  .:|||.:::.|.|     .|:.|.:..|
Human   533 SLLKSPLNHTQDAKLPSPLGNPALPLVSAVSNSSQGTTAAAGPEEKFESRLEDSCVEKLKTRSSD 597

  Fly   543 EEETPDEPKLVMDIEEPETKEMAPTPEATEAATPIKREESREASPDPESYRSSSQ--------AI 599
            ..:.       .|.|:..|  ...|...|...|....:...::.||.:..:..|.        .:
Human   598 MSDG-------SDFEDVNT--TTGTDLDTTTGTGSDLDSDVDSDPDKDKGKGKSAEGQPKFGGGL 653

  Fly   600 KQEQEPLNVAEERQTPV--EEHA----PVEH-------AAD---LRCSRCSKQFNHPTELVQHEK 648
            .....|.:|||   .||  .:|:    |.|.       |.|   ...|...|.|. |..:...||
Human   654 APPGAPNSVAE---VPVFYSQHSFFPPPDEQLLTATGAAGDSIKAIASIAEKYFG-PGFMGMQEK 714

  Fly   649 VLCGLIKEELEQHFQQQQATSF----------ALASASEEDEEDEEMDVEEEPRQESGERKVRVR 703
            .|..|   .....|..|...:|          |||         ..:.|:.||:......||...
Human   715 KLGSL---PYHSAFPFQFLPNFPHSLYPFTDRALA---------HNLLVKAEPKSPRDALKVGGP 767

  Fly   704 TAINEEQQQQLKQHYSLNARPSRDEFRMIAARLQLDPRVVQVWFQNNRSRERKMQSFQNNQAAGA 768
            :|         :..:.|..:|.             |.:.:.                        
Human   768 SA---------ECPFDLTTKPK-------------DVKPIL------------------------ 786

  Fly   769 APPMPIDSQASLTREDQPLDLSVKRDPLTPKSESSPPYIAPPSGEALNPEAINLSRKFSTSASMS 833
              |||....|..:.|:||||||:       .|.:.    |..:|....|...::..:....|...
Human   787 --PMPKGPSAPASGEEQPLDLSI-------GSRAR----ASQNGGGREPRKNHVYGERKLGAGEG 838

  Fly   834 PASISPSSAAALYFGAAPPPSPPNSQLDSTPRSGQAFPGLPPYMLPMSLPMEALFKMRPGGDFAS 898
            ...:.|         |..|..||......:|.          :|.|:...:|......|.|....
Human   839 LPQVCP---------ARMPQQPPLHYAKPSPF----------FMDPIYSRVEKRKVTDPVGALKE 884

  Fly   899 N---------HALMNSI-----KLPDY------RGTSLSPGGSEKRSWRDDDSRISHEDEFGAGV 943
            .         |..|::|     ||..:      .|:||.|......::|.....:|         
Human   885 KYLRPSPLLFHPQMSAIETMTEKLESFAAMKADSGSSLQPLPHHPFNFRSPPPTLS--------- 940

  Fly   944 LMPPKPRRGKAETHGHAGDPDLPYVCDQCDKAFAKQSSLARHKYEHSGQRPYQCIECPKAFKHKH 1008
              .|..|:||..           |.|..|.|.|.:.::|.||...|:|::||:|..|.::|....
Human   941 --DPILRKGKER-----------YTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISS 992

  Fly  1009 HLTEHKR-LHSGEKPFQCSKC-------------LKRFSHSGS-YSQH----MNH---------- 1044
            :|..|.| :|:.||||:|..|             ||:..|..: .|||    .||          
Human   993 NLQRHVRNIHNKEKPFKCHLCNRCFGQQTNLDRHLKKHEHENAPVSQHPGVLTNHLGTSASSPTS 1057

  Fly  1045 -----------RYSYCKPYREXVSDTSVPPTCQPGANPLAPPAMASNRGRRR--VQVPAGNPPYT 1096
                       ..||....|. ::::.:              ..||.|..:|  :|:..|:.   
Human  1058 ESDNHALLDEKEDSYFSEIRNFIANSEM--------------NQASTRTEKRADMQIVDGSA--- 1105

  Fly  1097 PHHQHPHHPHLAAMAAFQQQHQQQQ-----QQHQHHRLSWNGGGVMLPPPPSQQAHRPTAPHPPP 1156
               |.|      .:|:.:|:..:::     ::.....|:.......:.|.|..||.........|
Human  1106 ---QCP------GLASEKQEDVEEEDDDDLEEDDEDSLAGKSQDDTVSPAPEPQAAYEDEEDEEP 1161

  Fly  1157 LLSGSGFGQPPAAQFFH-------HHAGLLPPPPPP 1185
            ..|       .|..|.|       |..|||...|.|
Human  1162 AAS-------LAVGFDHTRRCAEDHEGGLLALEPMP 1190

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zfh1NP_733401.3 C2H2 Zn finger 291..311 CDD:275368 7/36 (19%)
C2H2 Zn finger 326..346 CDD:275368 8/19 (42%)
zf-C2H2 355..377 CDD:278523 9/21 (43%)
C2H2 Zn finger 357..377 CDD:275368 8/19 (42%)
zf-H2C2_2 369..391 CDD:290200 8/21 (38%)
Homeobox 703..755 CDD:278475 4/51 (8%)
C2H2 Zn finger 969..989 CDD:275368 7/19 (37%)
zf-H2C2_2 981..1006 CDD:290200 10/24 (42%)
COG5048 992..>1045 CDD:227381 23/92 (25%)
C2H2 Zn finger 997..1017 CDD:275368 6/20 (30%)
zf-H2C2_2 1009..1034 CDD:290200 12/38 (32%)
C2H2 Zn finger 1025..1042 CDD:275368 8/34 (24%)
PRDM16NP_071397.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..68
SET 84..209 CDD:214614
C2H2 Zn finger 283..303 CDD:275368 8/19 (42%)
zf-H2C2_2 295..319 CDD:290200 11/26 (42%)
C2H2 Zn finger 311..331 CDD:275368 8/19 (42%)
zf-C2H2 337..358 CDD:278523 7/20 (35%)
C2H2 Zn finger 339..357 CDD:275368 6/17 (35%)
zf-C2H2 366..388 CDD:278523 4/21 (19%)
C2H2 Zn finger 368..388 CDD:275368 4/19 (21%)
zf-C2H2_8 369..450 CDD:292531 13/80 (16%)
zf-C2H2 394..416 CDD:278523 3/21 (14%)
C2H2 Zn finger 396..416 CDD:275368 3/19 (16%)
C2H2 Zn finger 425..443 CDD:275368 4/17 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 533..657 25/132 (19%)
Interaction with CTBP1, CTBP2 and ZNF516. /evidence=ECO:0000250|UniProtKB:A2A935 679..1038 96/471 (20%)
Mediates interaction with SKI and regulation of TGF-beta signaling. /evidence=ECO:0000269|PubMed:19049980 739..1276 116/594 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 772..804 10/70 (14%)
COG5048 931..>1083 CDD:227381 42/173 (24%)
zf-C2H2 951..973 CDD:278523 8/21 (38%)
C2H2 Zn finger 953..973 CDD:275368 7/19 (37%)
zf-H2C2_2 965..989 CDD:290200 9/23 (39%)
zf-C2H2 979..1002 CDD:278523 7/22 (32%)
C2H2 Zn finger 981..1002 CDD:275368 6/20 (30%)
zf-C2H2 1008..1030 CDD:278523 5/21 (24%)
C2H2 Zn finger 1010..1030 CDD:275368 4/19 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1033..1065 5/31 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1105..1163 10/69 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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