DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zfh1 and zeb1

DIOPT Version :9

Sequence 1:	NP_733401.3	Gene:	zfh1 / 43650	FlyBaseID:	FBgn0004606	Length:	1206	Species:	Drosophila melanogaster
Sequence 2:	XP_012820104.1	Gene:	zeb1 / 548525	XenbaseID:	XB-GENE-484655	Length:	1121	Species:	Xenopus tropicalis

Alignment Length:	1142	Identity:	288/1142 - (25%)
Similarity:	419/1142 - (36%)	Gaps:	355/1142 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 YQSLSEHIASEHPHDKLNCGAAQPESDAEDEQSNMSGSSRRYAKSPLASNNNSSTANANNNSTSS 150
            |.|:.|..:.....|||:....:..:||.|.:.::.                     .::..|..
Frog    23 YNSVLEANSDSDDEDKLHIVEEESVTDAADGEGSVP---------------------EDDLPTDQ 66

  Fly   151 QSMNNNSELAKNHNSA---NKMSPMCSPGSLTPGDLFAQLQHPPPQLPPHLHAQFMAAAASLAMQ 212
            ..:...||.||.....   ::....||...|.|                    :..|......::
Frog    67 TVLPEGSESAKGSGKTCWEDEEGADCSDEILGP--------------------EAEADELGCTVK 111

  Fly   213 SARTASSPSQQQQQQLQQQQQLQQQQQHQMAMQQLLPPQLPGSNSSVGSNSAYDLDLSAPRSTSS 277
            .....|....:|.|....::.|||..      ..::.|:.|..:...|:..|...|
Frog   112 DEECDSDLENEQNQDPNVEEFLQQSD------TAVIYPEAPEDDQRQGTPEAVGQD--------- 161

  Fly   278 PGSTTGDLSGAYPCMQCTASFASREQLEQH-EQLHSPCGPAAVSNVSQTCRICHKAFANVYRLQR 341
            ...|....|....|..|...:.....|::| :..|..      :..:.:|.:|...||...:|.|
Frog   162 ENGTPDAFSQLLTCPYCDRGYKRFTSLKEHIKYRHEK------NEDNFSCSMCSYTFAYRTQLDR 220

  Fly   342 HMISH---------DESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGS 397
            ||.||         .:|...|||||.||.||||:|||||||:||||||||:.|.||.||||||||
Frog   221 HMTSHKSGKDQRHVTQSGGNRKFKCPECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGS 285

  Fly   398 FSSHMTSKKCISMGLKLNNNRALLK-------RLEKSPGSASSASRRSPSDHGKGKLPEQPSLPG 455
            :|||::|||||.:.......|:.||       .|..||||.:....|.       |:..:|....
Frog   286 YSSHISSKKCIGVAPVNGRVRSGLKTPQCSSPSLSASPGSPARPQIRQ-------KIENKPLQEQ 343

  Fly   456 LP------HPMSYFASDAQVQGGSAAPAPFPPFHPNYMNAALLA---FPHNFMAAAA----GLDP 507
            :|      .|:.|......|..|....||..  :..:.:.:.|.   .|...:.|..    ||
Frog   344 IPVNQIKTEPVDYEIKPIVVTSGINCSAPLQ--NGVFSSGSRLQATNSPQGVVQAVVLPTMGL-- 404

  Fly   508 RVHPYS-----IQRLLQLSAAGQQQRE---------EEREEQQ------KQQQH----------- 541
             |.|.|     ||.:|:::..|...|:         ..:|:..      :|..|
Frog   405 -VSPISINLNDIQNVLKVAVDGNVIRQVLENNHVSLASKEQGTLTSATIQQAGHSVISAISLPLV 468

  Fly   542 DEEETPDEPKLVMD--IEEPETKEMAPTPEATEAATPIKREESREASPDPESYRSSSQAIKQEQ- 603
            |::.|   .|::::  :|:|....:.......||..|                   ::..|.|:
Frog   469 DQDGT---TKIIINYSLEQPSQLPLVAQNLKKEATAP-------------------AEVCKTEKL 511

  Fly   604 -EPLNVAEERQTPVEEHAPVEHAADLRCSRCSKQFNHPTELVQHEKVLCGLIKEELEQ--HFQQQ 665
             |.|.:..|:.|...|.           |.|....:||.:            |..|::  |:.|:
Frog   512 PEDLTIKTEKDTKFTEE-----------STCLLGADHPGD------------KNALQEPKHYDQK 553

  Fly   666 QATSFALASASE--------EDEEDEEMDVEEEPRQESGERKVRVRTAINEEQQQQLKQHYSLNA 722
            :.:....:|.:|        .|.||..:...:.|          ::..::     .||.:|:|||
Frog   554 KNSLLPESSKAEPIKSEPTSADPEDGNLTPSQPP----------LKNLLS-----LLKAYYALNA 603

  Fly   723 RPSRDEFRMIAARLQLDPRVVQVWFQNNRSRERKMQSFQ-------------------------- 761
            :||.:|...||..:.|...||:.||:..::.|..::|.:
Frog   604 QPSSEELSKIADSVNLPLDVVKDWFEKMQNGEISVESSRPSSPKPGQDSVTENSVESKDESGLHN 668

  Fly   762 -------------------NNQAAGAAPPMPI--------------DSQASLTREDQPLDLSVKR 793
                               |...:|.|.|.|:              |......::.:|||||:
Frog   669 GTNVSLKSPKQEPEEPLAVNGPESGTASPTPLNLSSLKNSEGAACSDGTPDGEQQAEPLDLSL-- 731

  Fly   794 DPLTPKSESSPP------YIAPPSGEALNPEAINLSRKFSTSASMSPASISPSSAAALYFGAAPP 852
                ||...:.|      .:...|..::..|.:|||     .....|..:...:.|.......|.
Frog   732 ----PKPHGNVPERPSITSVYQSSSYSVQEEPLNLS-----CVKKEPMQVDDVTKAEPMLIINPS 787

  Fly   853 PSPPNSQLDSTPRSGQAFP---------GLP----------PYMLPM-----------SLPMEAL 887
            .:|.|..:   |......|         |:|          ..::|.           |:|...|
Frog   788 ANPINIAI---PTVTAQLPTIVAIADQNGVPCLRALAASKRTILIPQVTYTYSTTANPSVPEPQL 849

  Fly   888 FKMRPGGDFASNHALMNSIKLPDYRGTSLSPGGSEKRSWRDDDSRISHEDEFGAGVLMPPKPRRG 952
            ..::|.|:             .|.|..:.|.|.|......|.||             .|||.:..
Frog   850 KNIQPNGN-------------QDERQDTSSEGVSNVEDQNDSDS-------------TPPKKKLK 888

  Fly   953 KAETHGHAGDPDLPYVCDQCDKAFAKQSSLARHKYEHSGQRPYQCIECPKAFKHKHHLTEHKRLH 1017
            |.|..        .|.||.|||.|.|.|||.||||||:|:||::|..|.|||||||||.||.|||
Frog   889 KTENG--------LYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICAKAFKHKHHLIEHMRLH 945

  Fly  1018 SGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE 1054
            |||||:||.||.|||||||||||||||||||||...|
Frog   946 SGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKKEAE 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zfh1	NP_733401.3	C2H2 Zn finger	291..311	CDD:275368	4/20 (20%)
		C2H2 Zn finger	326..346	CDD:275368	8/19 (42%)
		zf-C2H2	355..377	CDD:278523	17/21 (81%)
		C2H2 Zn finger	357..377	CDD:275368	15/19 (79%)
		zf-H2C2_2	369..391	CDD:290200	16/21 (76%)
		Homeobox	703..755	CDD:278475	16/51 (31%)
		C2H2 Zn finger	969..989	CDD:275368	14/19 (74%)
		zf-H2C2_2	981..1006	CDD:290200	16/24 (67%)
		COG5048	992..>1045	CDD:227381	41/52 (79%)
		C2H2 Zn finger	997..1017	CDD:275368	14/19 (74%)
		zf-H2C2_2	1009..1034	CDD:290200	19/24 (79%)
		C2H2 Zn finger	1025..1042	CDD:275368	14/16 (88%)
zeb1	XP_012820104.1	GET2	<120..>173	CDD:370065	12/67 (18%)
		C2H2 Zn finger	175..196	CDD:275368	4/20 (20%)
		ZnF_C2H2	203..225	CDD:197676	8/21 (38%)
		C2H2 Zn finger	205..225	CDD:275368	8/19 (42%)
		zf-H2C2_2	218..254	CDD:372612	17/35 (49%)
		zf-C2H2	243..265	CDD:333835	17/21 (81%)
		C2H2 Zn finger	245..265	CDD:275368	15/19 (79%)
		zf-H2C2_2	257..280	CDD:372612	17/22 (77%)
		HOX	580..633	CDD:197696	17/67 (25%)
		C2H2 Zn finger	897..917	CDD:275368	14/19 (74%)
		zf-H2C2_2	909..934	CDD:372612	16/24 (67%)
		C2H2 Zn finger	925..945	CDD:275368	14/19 (74%)
		zf-H2C2_2	937..962	CDD:372612	19/24 (79%)
		C2H2 Zn finger	953..970	CDD:275368	14/16 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11373
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I2979
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380919at33208
OrthoFinder	1	1.000	-	-		FOG0002059
OrthoInspector	1	1.000	-	-		otm49072
Panther	1	1.100	-	-	O	PTHR24391
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4835
SonicParanoid	1	1.000	-	-		X1522
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190