DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zfh1 and Zfp236

DIOPT Version :9

Sequence 1:	NP_733401.3	Gene:	zfh1 / 43650	FlyBaseID:	FBgn0004606	Length:	1206	Species:	Drosophila melanogaster
Sequence 2:	NP_001361158.1	Gene:	Zfp236 / 329002	MGIID:	1926950	Length:	1847	Species:	Mus musculus

Alignment Length:	1650	Identity:	309/1650 - (18%)
Similarity:	475/1650 - (28%)	Gaps:	747/1650 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 KCTQCHKRFPEYQSLSEHI---ASEHPHDKLNCGAAQPESDAEDEQSNMSGSSRRYAKSPLASNN 136
            ||::|.|.|.:..:|..|:   ..|.||....|.||          .:..|:.:.:.:...:...
Mouse   228 KCSECGKAFNQKGALQTHMIKHTGEKPHACAFCPAA----------FSQKGNLQSHVQRVHSEVK 282

  Fly   137 NSSTANANNNSTSSQSMNN-NSELAKNHNSANKMSPMCSPGSLTPGD--------LFAQLQHPPP 192
            |..|.|....|...:|:.: |:.::|.|...       .|.|.|..:        :|..|   |.
Mouse   283 NGPTYNCTECSCVFKSLGSLNTHISKMHMGG-------PPNSTTSAETAHVITATIFQTL---PL 337

  Fly   193 QLPPHLHAQFMAAAASLAMQSARTASSPSQQQQQQLQQQQQLQQQQQHQMAMQ------------ 245
            |       |..|..:|::.:.:..|.|...||..:|.:...::.||..|...|
Mouse   338 Q-------QVEAQVSSVSSEQSSQAVSDVIQQLLELSEPGPVEAQQSPQSGRQLSVTVGINQDIL 395

  Fly   246 ---------QLLPPQLPGSN----------------SSVGSNSAYDLDLSAPRSTSSPGST---- 281
                     ..||...|.|:                |||.:..|..:|....:...||..|
Mouse   396 QQALENSGLSSLPVAAPPSDCSHAQTATVSTQSPHASSVSAEQADPMDAEQEKGQESPEKTDKKE 460

  Fly   282 -------TGDLSGA---------YPCMQCTASFASREQLEQHEQLHSPCGPAAVSNVSQTCRICH 330
                   :..|.|:         :.|..||..|.....|.:|.::|:...|.       .|..|.
Mouse   461 KKLLKKKSPFLPGSIREENGVRWHVCPYCTKEFRKPSDLVRHIRIHTHEKPF-------KCPQCF 518

  Fly   331 KAFANVYRLQRHMISHDESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHS 395
            :|||....|..|:.:|..   ::.|||:.|.|:|.....||.|:|:|:|.:||.|.:|.|:|..|
Mouse   519 RAFAVKSTLTAHIKTHTG---IKAFKCQYCMKSFSTSGSLKVHIRLHTGVRPFACPHCDKKFRTS 580

  Fly   396 GSFSSHMTSKKCISMGLKLNNNRALLKRLEKSPGSASSASRRSPSDHGKGKLPEQPSLP------ 454
            |...:|:.|.      .|....|.|.::.:...|..           ||..:| .|.:|
Mouse   581 GHRKTHVASH------FKHTELRKLRQQRKPVKGRV-----------GKSSVP-VPDIPLQEPIL 627

  Fly   455 ----GLPHPM---SYFASDAQVQGGSAAPAPFPPFH----------------------------- 483
                ||..|:   .:|.:......|:.|..|:..|:
Mouse   628 ITDLGLIQPIPKNQFFQNYFNNSFGNEADRPYKCFYCHRAYKKSCHLKQHIRSHTGEKPFKCSQC 692

  Fly   484 -PNYMNAALL--------------------AFP-----HNFMAAAAGLDPRVHPYSIQRLLQLSA 522
             ..:::|.:|                    ||.     ...|.....|.|.:.|| .|:..:.|.
Mouse   693 GRGFVSAGVLKAHVRTHTGLKSFKCLICNGAFTTGGSLRRHMGIHNDLRPYMCPY-CQKTFKTSL 756

  Fly   523 AGQQQREEEREE-QQKQQQHDEEETPDEPKLV----MDIEEP-----ETKEMAPTPE-------- 569
            ..::..:..|.| .|:.|||.|..:.|:...|    |.:..|     |:.|:..|||
Mouse   757 NCKKHMKTHRYELAQQLQQHQEASSMDDDSTVDQQSMHVAAPMPVEIESAELQQTPETVAADPES 821

  Fly   570 ----------ATEAAT--------PIKREE-----------------SREASPDPE--------- 590
                      .||.|.        |::.:|                 ..:.:|.|.
Mouse   822 ILELGPQHVVGTEDAALGQQLADQPLEADEDGFTASQAPLPGHMDQFEEQGTPQPSFESAGLPQG 886

  Fly   591 -------SYRSSSQAIKQEQ-------------------------EPLNVA-------EERQTPV 616
                   |.::|...::|.|                         :.:|||       .:....:
Mouse   887 FTVTDTYSQQTSFPPVQQLQDSSTLESQALSTSFHQQNLLQVPNSDAINVATRLLPESSQEDLDL 951

  Fly   617 EEHAP--VEHAAD-----LRCSRCSKQFNHPTELVQH------EK----VLC-------GLIK-- 655
            :...|  :|.:.|     .||..|:|.|...:.|.||      ||    .||       |::|
Mouse   952 QTQGPQFLEDSEDQSRRSYRCDYCNKGFKKSSHLKQHVRSHTGEKPYKCKLCGRAFVSSGVLKSH 1016

  Fly   656 -------------------------------------------EE-------LEQHFQQQQATSF 670
                                                       ||       ..:|.::.||.|.
Mouse  1017 EKTHTGVKAFSCSICNASFTTNGSLTRHMATHMSMKPYKCPFCEEGFRTAVHCRKHMKRHQAVSS 1081

  Fly   671 ALASAS---------EEDEEDEEMDVEEEPR-------------------QESG--ERKVRVRTA 705
            |.|:|:         |||||:.:.....:||                   |||.  ..||.|::|
Mouse  1082 AAAAAAETEGGDTCVEEDEENSDRSASRKPRPEVITFTEEETAQLAKIQPQESATVSEKVLVQSA 1146

  Fly   706 INEEQQQQLK-QHYSLNARPSR--------------------------------DEF-RMIAARL 736
            ..:::..::| :...|.|.|..                                ||. :....:.
Mouse  1147 AEKDRISEMKDKQAELEAEPKHANCCTYCPKSFKKPSDLVRHVRIHTGEKPYKCDECGKSFTVKS 1211

  Fly   737 QLDPRV-----------------------------------------VQVWFQNNRSRERKMQSF 760
            .||..|                                         .::.|:.:..|:..||..
Mouse  1212 TLDCHVKTHTGQKLFSCHVCSNAFSTKGSLKVHMRLHTGAKPFKCPHCELRFRTSGRRKTHMQFH 1276

  Fly   761 QNNQAAGAAPPMPIDSQASL--------------------------------------------- 780
            ..:....|..|:...|..||
Mouse  1277 YKSDPKKARKPVTRSSSESLQSVNLLNSSSTDPNVFIMNNSVLTGQFDQNVLQPGLVGQAILPAS 1341

  Fly   781 -----------------TREDQPLDL--------------------------------------S 790
                             |.|...|.|                                      |
Mouse  1342 VSAGGDLTVSLTDGSLATLEGIQLQLAANLVGPNVQISGIDASSINNITLQIDPSILQQTLQQGS 1406

  Fly   791 VKRDPLTPK------------SESSPP---YIAPPSGEALNPEAIN-------LSRKFSTSASMS 833
            :...|:|.:            |:|:.|   .|.|.||.:|.|...:       ||.:.|...:.|
Mouse  1407 LLAQPITGESSTASQNSSLQTSDSTVPASVVIQPLSGLSLQPTVTSANLTIGPLSEQDSVLTTSS 1471

  Fly   834 PAS-------------------------ISPSSAAALYFGAAPPP------SPPNSQL---DSTP 864
            ..|                         |:.||.:.:...||.|.      ||....|   :..|
Mouse  1472 SGSQDLSQVMTSQGLVSTSTGPHEITLTINNSSLSQVLAQAAGPTASSSSGSPQEITLTISELNP 1536

  Fly   865 RSGQAFPGLPPYMLPMSLPMEALFKMRPGGDFASNHALMNS---------IKLPDYRGT------ 914
            .||.         ||.:.||.      |....|.|..:.:|         :.|.|.:|.
Mouse  1537 SSGS---------LPSTAPMS------PSAISAQNLVMSSSGVGADASVTLTLADTQGVLSGGLD 1586

  Fly   915 --------------------SLS-PGGS-------------------EKRSWRDDD--------- 930
                                ||| .||:                   |:.:::..|
Mouse  1587 TVTLNITSQGQQFPALLTDPSLSGQGGAGSPQVILVSHTPQSSSAAGEEIAYQVTDVPAQLTPHS 1651

  Fly   931 ----SRISHE----DE--FGAGVLM-PPKPRRGKAETHG--------------------HAGDPD 964
                ..:||:    |.  ..|.||| ..|...||...||                    |...|.
Mouse  1652 QPEKEGLSHQCLDCDRAFSSAAVLMHHSKEVHGKERIHGCRVCRKAFKRATHLKEHMLTHQAGPS 1716

  Fly   965 LP------YVCDQCDKAFAKQSSLARHKYEHSGQRPYQCIECPKAFKHKHHLTEHKRLHSGEKPF 1023
            |.      :.||.|:|||||.|.|.||...|:|:||:.|..|.|||..|..|..|.:.|:||:|:
Mouse  1717 LSSQKPRVFKCDSCEKAFAKPSQLERHSRIHTGERPFHCTLCDKAFNQKSALQVHLKKHTGERPY 1781

  Fly  1024 QCSKCLKRFSHSGSYSQHMNHRYSY 1048
            :|..|:..|:...:...||...:|:
Mouse  1782 RCDYCVMGFTQKSNMKLHMKRAHSF 1806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zfh1	NP_733401.3	C2H2 Zn finger	291..311	CDD:275368	6/19 (32%)
		C2H2 Zn finger	326..346	CDD:275368	7/19 (37%)
		zf-C2H2	355..377	CDD:278523	10/21 (48%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	369..391	CDD:290200	10/21 (48%)
		Homeobox	703..755	CDD:278475	12/126 (10%)
		C2H2 Zn finger	969..989	CDD:275368	12/19 (63%)
		zf-H2C2_2	981..1006	CDD:290200	12/24 (50%)
		COG5048	992..>1045	CDD:227381	19/52 (37%)
		C2H2 Zn finger	997..1017	CDD:275368	8/19 (42%)
		zf-H2C2_2	1009..1034	CDD:290200	9/24 (38%)
		C2H2 Zn finger	1025..1042	CDD:275368	3/16 (19%)
Zfp236	NP_001361158.1	COG5048	<30..234	CDD:227381	3/5 (60%)
		C2H2 Zn finger	41..61	CDD:275368
		C2H2 Zn finger	70..90	CDD:275368
		C2H2 Zn finger	97..117	CDD:275368
		C2H2 Zn finger	125..145	CDD:275368
		C2H2 Zn finger	157..177	CDD:275368
		COG5048	197..>550	CDD:227381	76/358 (21%)
		C2H2 Zn finger	201..221	CDD:275368
		C2H2 Zn finger	229..249	CDD:275368	6/19 (32%)
		C2H2 Zn finger	257..278	CDD:275368	4/30 (13%)
		C2H2 Zn finger	289..310	CDD:275368	4/20 (20%)
		C2H2 Zn finger	486..506	CDD:275368	6/19 (32%)
		C2H2 Zn finger	514..534	CDD:275368	7/19 (37%)
		C2H2 Zn finger	542..562	CDD:275368	8/19 (42%)
		zf-H2C2_2	554..579	CDD:372612	12/24 (50%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		COG5048	653..1058	CDD:227381	61/405 (15%)
		C2H2 Zn finger	661..681	CDD:275368	1/19 (5%)
		C2H2 Zn finger	689..709	CDD:275368	2/19 (11%)
		C2H2 Zn finger	717..737	CDD:275368	3/19 (16%)
		C2H2 Zn finger	745..765	CDD:275368	4/20 (20%)
		COG5048	937..1317	CDD:227381	59/379 (16%)
		C2H2 Zn finger	972..992	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1000..1020	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1028..1048	CDD:275368	0/19 (0%)
		C2H2 Zn finger	1172..1192	CDD:275368	0/19 (0%)
		C2H2 Zn finger	1200..1220	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1228..1248	CDD:275368	0/19 (0%)
		C2H2 Zn finger	1256..1276	CDD:275370	4/19 (21%)
		Herpes_BLLF1	<1374..1675	CDD:282904	51/315 (16%)
		C2H2 Zn finger	1662..1683	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1691..1711	CDD:275368	0/19 (0%)
		C2H2 Zn finger	1727..1747	CDD:275368	12/19 (63%)
		zf-H2C2_2	1740..1764	CDD:372612	12/23 (52%)
		C2H2 Zn finger	1755..1775	CDD:275368	8/19 (42%)
		zf-H2C2_2	1767..1792	CDD:372612	9/24 (38%)
		C2H2 Zn finger	1783..1801	CDD:275368	4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000