Protein Alignment zfh1 and Zeb2

DIOPT Version :10

• Sequence 1: NP_733401.3
• Gene: zfh1 / 43650
• FlyBaseID: FBgn0004606
• Length: 1206
• Species: Drosophila melanogaster
• Sequence 2: NP_001028873.2
• Gene: Zeb2 / 311071
• RGDID: 1307272
• Length: 1215
• Species: Rattus norvegicus
• Alignment Length: 1224
• Identity: 319/1224 - (26%)
• Similarity: 486/1224 - (39%)
• Gaps: 318/1224 - (25%)

  Fly   107 AQPESDAEDEQSNMSGSSRRYAKSPLASNNNSSTANANNNSTSSQSMNNNSELAKNHNSANKMSP 171
            |..|:|.||:               |....:...||..:..||..||       .||.|:..||.
  Rat    34 AGSETDEEDK---------------LHIAEDDGIANPLDQETSPASM-------PNHESSPHMSQ 76

  Fly   172 MCSP--------------GSLTPGDLFAQLQHPPPQLPPHLHAQFMAAAASLAMQSARTASSPSQ 222
            ...|              .|...|::.......|.::.....|....|.....:.:....::...
  Rat    77 GLLPREEEEDEIRESVVEHSWHSGEILQASVDGPEEMKEDYDALGPEATIQTTINNGTVKNANCT 141

  Fly   223 QQQQQLQQQQQLQQQQQHQMAMQQLLP--------PQLPGSNSSVGSNSAYDLDLSAPRSTSSPG 279
            ...::...:::|:::..|.:::::.|.        |:.|...|.:|:..|     :.......|.
  Rat   142 SDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEA-----NGQEENDLPP 201

  Fly   280 STTGDLSGAYPCMQCTASFASREQLEQH-EQLHSPCGPAAVSNVSQTCRICHKAFANVYRLQRHM 343
            .|....:....|..|...:.....|::| :..|..      :..:.:|.:|...||...:|:|||
  Rat   202 GTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEK------NEENFSCPLCSYTFAYRTQLERHM 260

  Fly   344 ISH----DESALL------RKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSF 398
            ::|    |:..:|      |||||.||.||||:|||||||:||||||||:.|.||.||||||||:
  Rat   261 VTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSY 325

  Fly   399 SSHMTSKKC---ISMGLKLNNNRALLKRLEKSPGSASSA-------SRRSPSDHGKG-KLPEQPS 452
            |||::||||   ||:..::.||    .:...||.|.||:       ..|:..::||. .:.||..
  Rat   326 SSHISSKKCIGLISVNGRMRNN----IKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTG 386

  Fly   453 LPGL-PHPMSYFASDAQV--------------QGGSAAPAPFPPFHPNY----------MNAALL 492
            |..: ..|:.:  :|.:|              .||..|.:|. ..||:.          :.|.||
  Rat   387 LLKIKTEPLDF--NDYKVLMATHGFSGTSPFMNGGLGATSPL-GVHPSAQSPMQHLGVGLEAPLL 448

  Fly   493 AFPHNFMAAAAGLDPRVHPYSIQRLLQL--SAAGQQQREEEREEQQKQQQHDEEETPDEPKLVMD 555
            .||    ...:.|.      .:|::||:  :...:|:.:.:.|:..|.:.:..::...:|:
  Rat   449 GFP----TMNSNLS------EVQKVLQIVDNTVSRQKMDCKTEDISKLKGYHMKDPCSQPE---- 499

  Fly   556 IEEPETKEMAPT--------PEATEAATPIKREESREA-----SPDPESYRSSSQAIKQEQEPL- 606
             |:..|....|.        ..||::......|:..||     |...:|.|..|...|::...|
  Rat   500 -EQGVTSPSIPAVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLI 563

  Fly   607 -NVAEERQTPVEEHA-PVEHAADLRCSRCSKQFNHPTELVQHEKVLCGL---IKEELEQH--FQQ 664
             .|.:::.  :|.|: |...:    |..|.:.|..|..|.|||:.||.:   ||..|:.|  ...
  Rat   564 DLVTDDKM--IENHSIPTPFS----CQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVP 622

  Fly   665 QQATSFALASASEEDEEDEEMDVEEEPRQESGERKVRVRTAIN--EEQQQQLKQHYSLNARPSRD 727
            .:|..|.          |.:..:......|.|     :.:.||  ::....||.:|::|..|:.|
  Rat   623 NKAGVFV----------DNKALLLSSVLSEKG-----LTSPINPYKDHMSVLKAYYAMNMEPNSD 672

  Fly   728 EFRMIAARLQLDPRVVQVWFQNN----------------------------------RSRERKMQ 758
            |...|:..:.|....|:.||:..                                  ||..:.|.
  Rat   673 ELLKISIAVGLPQEFVKEWFEQRKVYQYSSSRSPSLERNSKPLAPNSNPTTKDSLLPRSPVKPMD 737

  Fly   759 SFQ-------NNQAAGAAPPMPIDSQASLTR---------------------------------- 782
            |..       :|......||:.:...:..|.
  Rat   738 SITSPSIAELHNSVTSCDPPLRLTKSSHFTNIKAVDKLDHSRSNTPSPLNLSSTSSKNSHSSSYT 802

  Fly   783 ---------EDQPLDLSVKRDPLTPKS-----------ESSPPYIAPPSGEALNPEAINLS---R 824
                     :.:|||||:.:....|||           ..|..:.:..|....:.|.:||:   :
  Rat   803 PNSFSSEELQAEPLDLSLPKQMREPKSIIATKNKTKATSISLDHNSVSSSSENSDEPLNLTFIKK 867

  Fly   825 KFSTSASMSPAS------ISPSSAAALYFGAAPPPS--PPNSQLDSTPRSGQAFPGLPPY--MLP 879
            :||.|.::...|      ::|.||..|| .|.||.|  ||.:.:   |....:.|||.||  :..
  Rat   868 EFSNSNNLDNKSTNPVFGMNPFSAKPLY-TALPPQSAFPPATFM---PPVQTSIPGLRPYPGLDQ 928

  Fly   880 MS-LPMEALFKMRPGGDFASNHALMNSIKLPDYRGTSLSPGGSEKRSWRDD----DSRISHEDEF 939
            || ||..|.........||.........:...::| .|..|..:..|..||    ||.:|.
  Rat   929 MSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQG-ELLDGAQDYMSGLDDLTDSDSCLSR---- 988

  Fly   940 GAGVLMPPKPRRGKAETHGHAGDPDLPYVCDQCDKAFAKQSSLARHKYEHSGQRPYQCIECPKAF 1004
                      ::.|....|       .|.||.|||.|.|.|||.||||||:|:||:||..|.|||
  Rat   989 ----------KKIKKTESG-------MYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAF 1036

  Fly  1005 KHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYREXVSDTSVPPTCQPGA 1069
            ||||||.||.||||||||:||.||.|||||||||||||||||||||  || ....:.....:...
  Rat  1037 KHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCK--REAEEREAAEREAREKG 1099

  Fly  1070 NPLAPPAMASNRGRRRVQVPAGNPPYTPHHQHPHHPHLAAMAAFQQQHQQQQQQ 1123
            : |.|..:..||...:...|.|   |:...:....|.   ....:::|:::.::
  Rat  1100 H-LEPTELLMNRAYLQSITPQG---YSDSEERESMPR---DGESEKEHEKEGEE 1146

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zfh1	NP_733401.3	C2H2 Zn finger	291..311	CDD:275368	4/20 (20%)
		C2H2 Zn finger	326..346	CDD:275368	8/19 (42%)
		zf-H2C2_2	338..365	CDD:463886	16/36 (44%)
		zf-C2H2	355..377	CDD:395048	17/21 (81%)
		C2H2 Zn finger	357..377	CDD:275368	15/19 (79%)
		zf-H2C2_2	369..391	CDD:463886	16/21 (76%)
		Homeodomain	701..756	CDD:459649	16/90 (18%)
		C2H2 Zn finger	969..989	CDD:275368	14/19 (74%)
		zf-H2C2_2	981..1006	CDD:463886	17/24 (71%)
		C2H2 Zn finger	997..1017	CDD:275368	14/19 (74%)
		zf-H2C2_2	1009..1034	CDD:463886	19/24 (79%)
		C2H2 Zn finger	1025..1042	CDD:275368	14/16 (88%)
Zeb2	NP_001028873.2	zf-Di19	209..263	CDD:428539	13/59 (22%)
		C2H2 Zn finger	213..234	CDD:275368	4/20 (20%)
		zf-C2H2	241..263	CDD:395048	8/21 (38%)
		C2H2 Zn finger	243..263	CDD:275368	8/19 (42%)
		zf-C2H2	282..304	CDD:395048	17/21 (81%)
		C2H2 Zn finger	284..304	CDD:275368	15/19 (79%)
		zf-H2C2_2	296..319	CDD:463886	17/22 (77%)
		C2H2 Zn finger	1001..1021	CDD:275368	14/19 (74%)
		zf-H2C2_2	1013..1038	CDD:463886	17/24 (71%)
		C2H2 Zn finger	1029..1049	CDD:275368	14/19 (74%)
		zf-H2C2_2	1041..1066	CDD:463886	19/24 (79%)
		C2H2 Zn finger	1057..1074	CDD:275368	14/16 (88%)