DRSC/TRiP Functional Genomics Resources

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Protein Alignment zfh1 and Zeb1

DIOPT Version :10

Sequence 1:NP_733401.3 Gene:zfh1 / 43650 FlyBaseID:FBgn0004606 Length:1206 Species:Drosophila melanogaster
Sequence 2:NP_035676.1 Gene:Zeb1 / 21417 MGIID:1344313 Length:1117 Species:Mus musculus


Alignment Length:1166 Identity:299/1166 - (25%)
Similarity:436/1166 - (37%) Gaps:372/1166 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    92 HIASEHP-HDKLNCGAAQPESDAEDEQSNMSGSSRRYAKSPLASNNNSSTANANNNSTSSQSMNN 155
            ||..|.. .|..:|....|:.:...:|:.:.|.|.|          .....|...::......::
Mouse    40 HIVEEESITDAADCEGGMPDDELPADQTVLPGGSDR----------GGGAKNCWQDNVKDNECDS 94

  Fly   156 NSELAKNHNSANKMSPMCSPGSLTPGDLFAQLQHPPPQLPPHLHAQFMAAAASLAMQSARTASSP 220
            ::|..:||:                               |::                      
Mouse    95 DAENEQNHD-------------------------------PNV---------------------- 106

  Fly   221 SQQQQQQLQQQQQLQQQQQHQMAMQQLLPPQLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGD- 284
                      ::.||||.      ..::.|:.|..:...|:          |.::|...:.|.| 
Mouse   107 ----------EEFLQQQD------TAVIYPEAPEEDQRQGT----------PEASSHDENGTPDA 145

  Fly   285 LSGAYPCMQCTASFASREQLEQH-EQLHSPCGPAAVSNVSQTCRICHKAFANVYRLQRHMISH-- 346
            .|....|..|...:.....|::| :..|..      :..:.:|.:|...||...:|:|||.||  
Mouse   146 FSQLLTCPYCDRGYKRFTSLKEHIKYRHEK------NEDNFSCSLCSYTFAYRTQLERHMTSHKS 204

  Fly   347 -------DESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTS 404
                   .:|...|||||.||.||||:|||||||:||||||||:.|.||.||||||||:|||::|
Mouse   205 GREQRHVTQSGGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISS 269

  Fly   405 KKCISM---------GLKLNNNRALLKRLEKSPGSASSASRRSPSDHGKGKLPEQPSLPGLPHPM 460
            |||||:         |||  .::.....|..||||.:....|.       |:..:|    |..|:
Mouse   270 KKCISLMPVNGRPRSGLK--TSQCSSPSLSTSPGSPTRPQIRQ-------KIENKP----LQEPL 321

  Fly   461 S-------------------------------YFASDAQVQGGSAAPAPFPPFHPNYMNAALLAF 494
            |                               .|:|..|:|..|:.        ...:.|.:|  
Mouse   322 SVNQIKTEPVDYEFKPIVVASGINCSTPLQNGVFSSGGQLQATSSP--------QGVVQAVVL-- 376

  Fly   495 PHNFMAAAAGLDPRVHPYS-----IQRLLQLSAAGQQQREEEREEQQKQQQHDEEETPDEPKLVM 554
                  ...||   |.|.|     ||.:|:::..|...|:                         
Mouse   377 ------PTVGL---VSPISINLSDIQNVLKVAVDGNVIRQ------------------------- 407

  Fly   555 DIEEPETKEMAPTPEATEAATPIKREESREASPDPESYRSSSQAIKQEQEPLNVAEERQTPVEEH 619
                        ..|..:|:...|.:|:..|||..:...|...||..   || |.::..|.:..:
Mouse   408 ------------VLETNQASLASKEQEAVSASPIQQGGHSVISAISL---PL-VDQDGTTKIIIN 456

  Fly   620 APVEHAADLRC--SRCSKQFNHPTELVQHEKVLCGL-IKEELEQHFQQQQATSFALA-------- 673
            ..:|..:.|:.  ....|:...||...:.||:...| :|.|.::.|:..:..|..|.        
Mouse   457 YSLEQPSQLQVVPQNLKKEIPAPTNSCKSEKLPEDLTVKSETDKSFEGARDDSTCLLCEDCPGDL 521

  Fly   674 -SASEEDEEDEEMDVEEEPRQESGER-KVRVRTAINEEQQQQ----------LKQHYSLNARPSR 726
             :..|....|.|...:..|...:.|: :....:|.|.:....          ||.:|:|||:||.
Mouse   522 NALPELKHYDPECPAQPPPPAPATEKPESSASSAGNGDLSPSQPPLKNLLSLLKAYYALNAQPST 586

  Fly   727 DEFRMIAARLQLDPRVVQVWFQNNRSRERKMQSFQNNQAAGAAPPMPIDSQASL---TRED---Q 785
            :|...||..:.|....|:.||:       |||:   .|..|.:|..|.....|:   |:.|   |
Mouse   587 EELSKIADSVNLPLDGVKKWFE-------KMQA---GQIPGQSPDPPSPGTGSVNIPTKTDEQPQ 641

  Fly   786 PLDLSVKRDPLT-----PKSESSPPYIAPPSGEALN--------PEAINL-----SRKFSTSA-- 830
            |.|.:..::..|     .|..|||   ..|.|.|:|        |..:||     .:.:|..|  
Mouse   642 PADGNEPQEDSTRGQSPVKIRSSP---VLPVGSAMNGSRSCTSSPSPLNLCSARNPQGYSCVAEG 703

  Fly   831 -----SMSPASIS----------PSSAAALYFG--------------AAPPPSPPNSQLDSTPRS 866
                 .:.|..:|          .|:.:::|..              |...|...:...||.|  
Mouse   704 AQEEPQVEPLDLSLPKQQGELLERSTVSSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEP-- 766

  Fly   867 GQAFPGLPPYMLPMSLPMEALFKMRPG----GD---------FASNHALMNSIKLPD----YRGT 914
              ....:||...|:::.:..:....|.    .|         .|:|   ..:|.:|.    |..|
Mouse   767 --VVNVVPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAAN---KQTILIPQVAYTYSAT 826

  Fly   915 -----------SLSPGGSEKRSWRDDDSRISHEDEFGAGVLMPPKPRRGKAETHGHAGDPDLPYV 968
                       .:.|.|::..........:|..::.......|||.:..|.|..        .|.
Mouse   827 VSPAVQEPPVKVIQPNGNQDERQDTSSEGVSTVEDQNDSDSTPPKKKTRKTENG--------MYA 883

  Fly   969 CDQCDKAFAKQSSLARHKYEHSGQRPYQCIECPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFS 1033
            ||.|||.|.|.|||.||||||:|:||::|..|.|||||||||.||.||||||||:||.||.||||
Mouse   884 CDLCDKIFQKSSSLLRHKYEHTGKRPHECGICRKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFS 948

  Fly  1034 HSGSYSQHMNHRYSYCK---PYREXVSDTSVPPTCQP--------GANPLAPPAMASNRGR 1083
            |||||||||||||||||   ..|:.:......|...|        ||.  |.|:.|.:..|
Mouse   949 HSGSYSQHMNHRYSYCKRGAEDRDAMEQEDAGPEVLPEVLATEHVGAR--ASPSQADSDER 1007

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zfh1NP_733401.3 C2H2 Zn finger 291..311 CDD:275368 4/20 (20%)
C2H2 Zn finger 326..346 CDD:275368 8/19 (42%)
zf-H2C2_2 338..365 CDD:463886 16/35 (46%)
zf-C2H2 355..377 CDD:395048 17/21 (81%)
C2H2 Zn finger 357..377 CDD:275368 15/19 (79%)
zf-H2C2_2 369..391 CDD:463886 16/21 (76%)
Homeodomain 701..756 CDD:459649 17/64 (27%)
C2H2 Zn finger 969..989 CDD:275368 14/19 (74%)
zf-H2C2_2 981..1006 CDD:463886 16/24 (67%)
C2H2 Zn finger 997..1017 CDD:275368 14/19 (74%)
zf-H2C2_2 1009..1034 CDD:463886 19/24 (79%)
C2H2 Zn finger 1025..1042 CDD:275368 14/16 (88%)
Zeb1NP_035676.1 C2H2 Zn finger 182..202 CDD:275368 8/19 (42%)
zf-C2H2 220..242 CDD:395048 17/21 (81%)
C2H2 Zn finger 222..242 CDD:275368 15/19 (79%)
zf-H2C2_2 234..257 CDD:463886 17/22 (77%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 278..307 8/30 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 476..501 7/24 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 528..566 6/37 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 613..687 20/76 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 834..876 6/41 (15%)
C2H2 Zn finger 884..904 CDD:275368 14/19 (74%)
zf-H2C2_2 896..921 CDD:463886 16/24 (67%)
C2H2 Zn finger 912..932 CDD:275368 14/19 (74%)
zf-H2C2_2 924..949 CDD:463886 19/24 (79%)
C2H2 Zn finger 940..957 CDD:275368 14/16 (88%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 991..1117 6/19 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..103 13/72 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 122..143 4/30 (13%)
C2H2 Zn finger 152..173 CDD:275368 4/20 (20%)
zf-C2H2 180..202 CDD:395048 8/21 (38%)

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