DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zfh1 and MECOM

DIOPT Version :9

Sequence 1:	NP_733401.3	Gene:	zfh1 / 43650	FlyBaseID:	FBgn0004606	Length:	1206	Species:	Drosophila melanogaster
Sequence 2:	XP_005247270.1	Gene:	MECOM / 2122	HGNCID:	3498	Length:	1240	Species:	Homo sapiens

Alignment Length:	1179	Identity:	243/1179 - (20%)
Similarity:	395/1179 - (33%)	Gaps:	346/1179 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FGQEDTIIQQSMP------STSPFAMQFPSLASTLLHHNQSPKHSNPGSSG--IQDAHP------ 62
            :|....|..:.||      ||....:|.|...:| .....:||..:|..:.  |.|..|
Human    18 YGNYPEIPLEEMPDADGVASTPSLNIQEPCSPAT-SSEAFTPKEGSPYKAPIYIPDDIPIPAEFE 81

  Fly    63 ----NQPGAAADAFLVKCTQCHKRFPEY----------QSLSEHIASEHPHDKLNCGAAQPESDA 113
                |.|||....:..:..:..::|..|          .|....|..|..:.|....|:||:
Human    82 LRESNMPGAGLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEILDEFYNVKFCIDASQPD--- 143

  Fly   114 EDEQSNMSGSSRRYAKSPLASNNNSSTANANNNSTSSQSMNNNSELAKNHNSANKMSPMCSPGSL 178
                   .||..:|.:.....:.::..|...|:....:.:                      ..:
Human   144 -------VGSWLKYIRFAGCYDQHNLVACQINDQIFYRVV----------------------ADI 179

  Fly   179 TPGD---LFAQLQ-HPPPQLPPHLHA----------QFMAAAASLAMQSARTASSP-------SQ 222
            .||:   ||.:.: :|...:.|.:|.          |...:.|.||.......|:|       .:
Human   180 APGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEE 244

  Fly   223 QQQQQLQQQQQLQQQQQHQMAMQ--QLLPPQLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDL 285
            ..||:|:.:..||:....|...:  |:.|        .:.|...:.|..:..|.
Human   245 DFQQKLESENDLQEIHTIQECKECDQVFP--------DLQSLEKHMLSHTEERE----------- 290

  Fly   286 SGAYPCMQCTASFASREQLEQHEQLHSPCGPAAVSNVSQTCRICHK-AFANVYRLQRHMISHDES 349
               |.|.||..:|..:..|.:|:..|.       |.....|..|.| .|.:...||||:.|....
Human   291 ---YKCDQCPKAFNWKSNLIRHQMSHD-------SGKHYECENCAKQVFTDPSNLQRHIRSQHVG 345

  Fly   350 ALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSH-------MTSKKC 407
            |  |...|.||.|.|.....||:|..|||..|||.|:.|.|.::...:...|       .|..||
Human   346 A--RAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKC 408

  Fly   408 ISMGLKLNNNRALLKRLEKSPGSASSASRRSPSDHGKG-KLPEQPSL------------PGLPHP 459
            ...|...:...:|.|......|....|   :....|:| .||..|::            |||
Human   409 KDCGQMFSTTSSLNKHRRFCEGKNHFA---AGGFFGQGISLPGTPAMDKTSMVNMSHANPGL--- 467

  Fly   460 MSYFASDAQVQGGSAAPAP-----FPPFHPN--YMNAALLAFPHNFMAAAAGLD----------- 506
            ..||.::....|.:...||     ||...|:  |....|:  |.:  :...||.
Human   468 ADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLI--PAS--SPVKGLSSTEQTNKSQSP 528

  Fly   507 ----PRVHPYSIQRLLQLSAAGQQQREEEREEQQKQQQHDEEETPDEPKLVMDIEEPETKEMAPT 567
                |::.| :.|.:|:  |..:.....:.:..:.|.:...||.|.|.  :.|..|....:...|
Human   529 LMTHPQILP-ATQDILK--ALSKHPSVGDNKPVELQPERSSEERPFEK--ISDQSESSDLDDVST 588

  Fly   568 PEATEAATPIKREESREASPDPESYRSSSQAIKQEQEPLNVAEERQTPVEEHAPVEHAADLRCSR 632
            |..::..|....:...:...|.|.::.:.:..|.:..||.                   :|....
Human   589 PSGSDLETTSGSDLESDIESDKEKFKENGKMFKDKVSPLQ-------------------NLASIN 634

  Fly   633 CSKQF-NHP--TELVQHEKVLCGLIKEELEQHFQQQQATSFALASASEEDEEDEEMDVEEEPRQE 694
            ..|:: ||.  :..::.:..:.|.:.:.::           |:||.:|
Human   635 NKKEYSNHSIFSPSLEEQTAVSGAVNDSIK-----------AIASIAE----------------- 671

  Fly   695 SGERKVRVRTAINEEQQQQLKQHYSLNARPSRDEFRMIAARLQLDPRVVQVWF----QNNRSRER 755
                |....|.:...|.::      :.|.|....|     .|...|...|..:    ::.||...
Human   672 ----KYFGSTGLVGLQDKK------VGALPYPSMF-----PLPFFPAFSQSMYPFPDRDLRSLPL 721

  Fly   756 KMQSFQNNQAAGAAPPMPIDSQASLTREDQPLDLSVKR---DPLTPKSESSPPYIAPPSGEALNP 817
            ||:.    |:.|....:...|..|      |.||:.||   .|||| ..|.|| :.|.:.:
Human   722 KMEP----QSPGEVKKLQKGSSES------PFDLTTKRKDEKPLTP-VPSKPP-VTPATSQ---- 770

  Fly   818 EAINLSRKFSTSASMSPASISPSSAAAL-------YFGAAPPPSPPNSQLDSTPRSGQAFPGLPP 875
                     .....:|..|.|.:|...|       .||     ....|.::|.|.|..:.....|
Human   771 ---------DQPLDLSMGSRSRASGTKLTEPRKNHVFG-----GKKGSNVESRPASDGSLQHARP 821

  Fly   876 ---YMLP--------MSLPMEALFK--MRPGGDFASNHALMNSIKLPDYRGTSLSPGGSEKRSWR 927
               :|.|        ::.|:|||.:  :||...|..:    ...:|||            :|:|.
Human   822 TPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFH----PQFQLPD------------QRTWM 870

  Fly   928 DDDSRISHE-DEFGA----------------GVLMPPKP------RRGKAETHGHAGDPDLPYVC 969
            .....::.: :.|.|                ....||..      |:||..           |.|
Human   871 SAIENMAEKLESFSALKPEASELLQSVPSMFNFRAPPNALPENLLRKGKER-----------YTC 924

  Fly   970 DQCDKAFAKQSSLARHKYEHSGQRPYQCIECPKAFKHKHHLTEHKR-LHSGEKPFQCSKCLKRFS 1033
            ..|.|.|.:.::|.||...|:|::||:|..|.::|....:|..|.| :|:.||||:|..|.:.|.
Human   925 RYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCDRCFG 989

  Fly  1034 HSGSYSQHM 1042
            ...:..:|:
Human   990 QQTNLDRHL 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zfh1	NP_733401.3	C2H2 Zn finger	291..311	CDD:275368	6/19 (32%)
		C2H2 Zn finger	326..346	CDD:275368	8/20 (40%)
		zf-C2H2	355..377	CDD:278523	8/21 (38%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	369..391	CDD:290200	11/21 (52%)
		Homeobox	703..755	CDD:278475	10/55 (18%)
		C2H2 Zn finger	969..989	CDD:275368	7/19 (37%)
		zf-H2C2_2	981..1006	CDD:290200	10/24 (42%)
		COG5048	992..>1045	CDD:227381	17/52 (33%)
		C2H2 Zn finger	997..1017	CDD:275368	6/20 (30%)
		zf-H2C2_2	1009..1034	CDD:290200	11/25 (44%)
		C2H2 Zn finger	1025..1042	CDD:275368	3/16 (19%)
MECOM	XP_005247270.1	PR-SET_PRDM3	47..204	CDD:380991	31/189 (16%)
		C2H2 Zn finger	211..260	CDD:275368	11/48 (23%)
		C2H2 Zn finger	265..285	CDD:275368	4/27 (15%)
		zf-H2C2_2	277..301	CDD:372612	7/37 (19%)
		zf-C2H2	291..313	CDD:333835	7/21 (33%)
		C2H2 Zn finger	293..313	CDD:275368	6/19 (32%)
		C2H2 Zn finger	321..343	CDD:275368	9/21 (43%)
		zf-H2C2_2	334..360	CDD:372612	12/27 (44%)
		zf-C2H2	349..371	CDD:333835	8/21 (38%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		zf-C2H2	377..399	CDD:333835	5/21 (24%)
		C2H2 Zn finger	379..399	CDD:275368	4/19 (21%)
		C2H2 Zn finger	408..426	CDD:275368	4/17 (24%)
		zf-C2H2	922..944	CDD:333835	8/21 (38%)
		C2H2 Zn finger	924..944	CDD:275368	7/19 (37%)
		zf-H2C2_2	936..960	CDD:372612	9/23 (39%)
		C2H2 Zn finger	952..973	CDD:275368	6/20 (30%)
		zf-H2C2_2	964..990	CDD:372612	11/25 (44%)
		C2H2 Zn finger	981..1001	CDD:275368	4/18 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910