DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zfh1 and zeb1a

DIOPT Version :9

Sequence 1:	NP_733401.3	Gene:	zfh1 / 43650	FlyBaseID:	FBgn0004606	Length:	1206	Species:	Drosophila melanogaster
Sequence 2:	XP_001344107.4	Gene:	zeb1a / 100004929	ZFINID:	ZDB-GENE-070912-124	Length:	1190	Species:	Danio rerio

Alignment Length:	1249	Identity:	301/1249 - (24%)
Similarity:	435/1249 - (34%)	Gaps:	449/1249 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 CGAAQPESDAEDEQS----NMSGSSRRYAKSPL-----ASNNNSSTANANNNSTSSQSMNNNSEL 159
            |...:..||::||..    ...|.:....:.|.     |:..||.|...::
Zfish    24 CSVPEATSDSDDEDKLQIVEEDGVAEDLDQKPTVLQLKAAQQNSDTCTQDD-------------- 74

  Fly   160 AKNHNSANKMSPMCSPGSLTPGDLFAQLQHPPPQLPPHLHAQFMAAAASLAMQSARTASSPSQQQ 224
                            |||.|..|..:::                      ::....:......|
Zfish    75 ----------------GSLGPETLIREIR----------------------VKEECVSDEEDGAQ 101

  Fly   225 QQQLQQQQQLQQQQQHQMAMQQLLPPQLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLSGAY 289
            .:...:::|.:.:            |..|        ::|.:...:..|.......|....|..:
Zfish   102 DEATSEEKQTKTE------------PVYP--------DAAEEHQRTPERGVHDENGTPDAFSHLH 146

  Fly   290 PCMQCTASFASREQLEQHEQL-HSPCGPAAVSNVSQTCRICHKAFANVYRLQRHMISHDE----- 348
            .|..|:..:.....|::|.:| |..      ::.:..|.:|...|....:|.|||.:|.:
Zfish   147 NCPHCSRGYKRHTSLKEHIKLRHEK------NDDNYCCSLCSYTFTYRTQLVRHMTAHRQLREKR 205

  Fly   349 ---SALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISM 410
               .:..|||||.||.||||:|||||||:||||||||:.|.||.||||||||:|||::||||.|:
Zfish   206 TVTQSGSRKFKCTECSKAFKYKHHLKEHLRIHSGEKPYECPNCRKRFSHSGSYSSHISSKKCSSI 270

  Fly   411 -------GLKLN------------------NNRALLKRL------------EKSPGSASSASRRS 438
                   |:|..                  .|:...|:|            :..|.||:.|...:
Zfish   271 IGVTRTPGVKTTITIPRPTHILLREKVVNITNKPPQKQLTLKQIKQEPVEHQPKPASATPAMAAT 335

  Fly   439 PSDHGKGKLPEQPSLP-------GLPHPMSYFASDAQ--------------------VQGGSA-- 474
            .::   |.:..|..|.       ||..|:|...||.|                    ..|.||
Zfish   336 TTN---GVVAPQSVLQTLVLPTVGLVQPISINLSDLQNALNVAMDSNVMRQMVTSTNANGTSAKI 397

  Fly   475 ---APAPF--------------------------------PPFHPNY---MNAALLAFPHNFMAA 501
               .||..                                |....||   ::..|.|...|....
Zfish   398 VGQVPAQTQAVVLQPQQTQSQTQPQVISAISLPVVGQDGNPKIIINYNPQLDRQLKAVKVNTTQP 462

  Fly   502 AAGL--------------DPRV-HPYSIQRLLQLSAAGQQQREEEREEQQKQ-----QQHDEEET 546
            |.|.              .|:| ..:|:|     |::.:.|.....:..|..     |..:..:|
Zfish   463 AVGQTNVTQTNSTTSNVPQPKVLQVHSLQ-----SSSSENQASGTAKPTQVNIIKPVQMGNLSKT 522

  Fly   547 PD------------------EPKLV--------------------MDIEEPETK--EMAPTPE-A 570
            |.                  :|||.                    |.:....|:  |:..||| .
Zfish   523 PSIIKITPAQAARLAQARAAQPKLTHQTLLLVRRADGSQSLVVRQMPVTNSNTQATELKSTPEKT 587

  Fly   571 TEAATPIKREESREA-------------------SPDPESYRSSSQAIKQEQEPLNVAEERQTPV 616
            |:.||    ||::|.                   ..:|||.......|:.|.|....|:|.:
Zfish   588 TDTAT----EETKETDNTENCEEQNLTAPIGIQIKTEPESPSKIEPEIQSEGEGEMQADENE--- 645

  Fly   617 EEHAPVEHAAD-LRCS-------RCSKQFNHPTELVQHEKVLCGLI------KEELEQHFQQQQA 667
            ||........| :.||       .|...|        |....|.|.      ::.||......:|
Zfish   646 EEETETASKTDKVSCSGTVHAGVSCGDNF--------HNYAYCLLCDSCPGKRKMLESKESNAKA 702

  Fly   668 --TSFALASASEEDEEDEEMDVEEEPRQESGERKVRVRTAINEEQQQQLKQHYSLNARPSRDEFR 730
              |:.:|.|..::|              :||.          .|:...|.:.||.|..|:.::..
Zfish   703 SPTTISLNSLLDKD--------------KSGA----------AERLLPLLKAYSQNPEPTEEQLA 743

  Fly   731 MIAARLQLDPRVVQVWFQNNRSRERKMQ--------------------SFQNNQAAGAAPP---- 771
            .:|..::|....|..|::..||:...:|                    |.|:.:.....||
Zfish   744 QVAKTVKLPLAAVTKWYEKMRSKRILLQATGNSKNKKTPPSPESQEPTSTQDTRTPSPTPPPDSS 808

  Fly   772 -----------MPIDSQASLTRED---------------QPLDLSVKRDPLTPKSESSPPYIAPP 810
                       .|....||::.:|               :|||||:      |||.|:.|.....
Zfish   809 PSEEEQNRSTASPASPPASVSTDDLVIVKTEEVEEELQCEPLDLSL------PKSSSTLPGTITK 867

  Fly   811 SGEALNPEAINLSRK----------FSTSASMSPASISPSSAAALYFGAAPPPSPPNSQLDSTPR 865
            ...:...|.:|||..          :....|..|.:|..:|...|...|.|...|..|...|..:
Zfish   868 LPVSSQKEPLNLSSLNKQTLAGNTIYVAQGSTGPLNIMSASLPTLVAIAEPGGVPCISSAISGNK 932

  Fly   866 SGQAFPGLPPYMLPMSLPMEALFKMRPGGDFASNHALMNSIKLPDYRGTSLSPGGSEKRSWRDDD 930
            .....|.|.........|..||.:.:      |...|.||.|:.|.    .|...||:::  |::
Zfish   933 RTILIPQLTYTYNSTEAPNNALTEKK------SMVILNNSPKMADV----TSDCTSEEQN--DEE 985

  Fly   931 SRISHEDEFGAGVLMPPKPRRGKAETHGHAGDPDLPYVCDQCDKAFAKQSSLARHKYEHSGQRPY 995
            .:|....:...|:                       |.||.|||.|.|.|||.||||||:|:||:
Zfish   986 MQIIKRRKTFTGM-----------------------YACDLCDKIFQKSSSLLRHKYEHTGKRPH 1027

  Fly   996 QCIECPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCK----PYREXV 1056
            :|..|.|||||||||.||.||||||||:||.||.|||||||||||||||||||||    ...| :
Zfish  1028 ECSICNKAFKHKHHLIEHTRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKRETQELPEHI 1092

  Fly  1057 SDTSVPPTCQPGAN 1070
            |.::.||: ||.::
Zfish  1093 STSTTPPS-QPDSD 1105

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zfh1	NP_733401.3	C2H2 Zn finger	291..311	CDD:275368	5/20 (25%)
		C2H2 Zn finger	326..346	CDD:275368	7/19 (37%)
		zf-C2H2	355..377	CDD:278523	17/21 (81%)
		C2H2 Zn finger	357..377	CDD:275368	15/19 (79%)
		zf-H2C2_2	369..391	CDD:290200	16/21 (76%)
		Homeobox	703..755	CDD:278475	12/51 (24%)
		C2H2 Zn finger	969..989	CDD:275368	14/19 (74%)
		zf-H2C2_2	981..1006	CDD:290200	16/24 (67%)
		COG5048	992..>1045	CDD:227381	41/52 (79%)
		C2H2 Zn finger	997..1017	CDD:275368	14/19 (74%)
		zf-H2C2_2	1009..1034	CDD:290200	19/24 (79%)
		C2H2 Zn finger	1025..1042	CDD:275368	14/16 (88%)
zeb1a	XP_001344107.4	C2H2 Zn finger	148..169	CDD:275368	5/20 (25%)
		C2H2 Zn finger	178..198	CDD:275368	7/19 (37%)
		zf-C2H2	215..237	CDD:278523	17/21 (81%)
		C2H2 Zn finger	217..237	CDD:275368	15/19 (79%)
		zf-H2C2_2	229..252	CDD:290200	17/22 (77%)
		C2H2 Zn finger	1001..1021	CDD:275368	14/19 (74%)
		zf-H2C2_2	1013..1038	CDD:290200	16/24 (67%)
		COG5048	1024..>1077	CDD:227381	41/52 (79%)
		C2H2 Zn finger	1029..1049	CDD:275368	14/19 (74%)
		zf-H2C2_2	1041..1066	CDD:290200	19/24 (79%)
		C2H2 Zn finger	1057..1074	CDD:275368	14/16 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11653
eggNOG	1	0.900	-	-		E1_KOG3623
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2747
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380919at33208
OrthoFinder	1	1.000	-	-		FOG0002059
OrthoInspector	1	1.000	-	-		otm24430
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24391
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1522
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	11.020